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Tytuł pozycji:

Soluble HLA-G is upregulated in serum of patients with severe COVID-19.

Tytuł :
Soluble HLA-G is upregulated in serum of patients with severe COVID-19.
Autorzy :
Al-Bayatee NT; Biotechnology Department, College of Science, University of Baghdad, Baghdad, Iraq.
Ad'hiah AH; Tropical-Biological Research Unit, College of Science, University of Baghdad, Baghdad, Iraq. Electronic address: .
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Źródło :
Human immunology [Hum Immunol] 2021 Oct; Vol. 82 (10), pp. 726-732. Date of Electronic Publication: 2021 Jul 16.
Typ publikacji :
Journal Article
Język :
English
Imprint Name(s) :
Original Publication: [New York] Elsevier/North-Holland.
Contributed Indexing :
Keywords: Coronavirus disease 19; Receiver operating characteristic; Severity; Soluble HLA-G; Vitamin D
Entry Date(s) :
Date Created: 20210726 Latest Revision: 20210920
Update Code :
20210921
PubMed Central ID :
PMC8282477
DOI :
10.1016/j.humimm.2021.07.007
PMID :
34304938
Czasopismo naukowe
Soluble HLA-G (sHLA-G) molecules are considered potent immunomodulators, and their dysregulated expression has been implicated in several pathological conditions, including coronavirus disease 19 (COVID-19). Therefore, a case-control study (103 COVID-19 patients and 105 controls) was performed to determine sHLA-G role in severity of COVID-19. Results revealed that median levels of sHLA-G were significantly increased in serum of patients compared to controls (19.3 vs. 12.7 ng/mL; p <0.001). When patients and controls were stratified by age group, gender, body mass index, chronic disease, or ABO and Rh blood groups, the sHLA-G level did not show a significant difference in each stratum. Logistic regression analysis demonstrated that the up-regulated expression of sHLA-G was associated with an elevated risk of developing COVID-19. Receiver operating characteristic curve analysis showed that sHLA-G was a very good predictor of COVID-19, and at a cut-off value of 15.4 ng/mL, the sensitivity and specificity of sHLA-G were 79.6 and 79.0%, respectively. Spearman rank correlation analysis revealed that sHLA-G was positively correlated with age, erythrocyte sedimentation rate, white blood cell count, and random blood glucose, while a negative correlation was recorded with vitamin D. In conclusion, up-regulated expression of sHLA-G was indicated in patients with severe COVID-19.
(Copyright © 2021 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.)

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