Association of cardiovascular risk burden with risk of dementia and brain pathologies: A population-based cohort study.

Szczegóły
Abstrakt

Tytuł:: Association of cardiovascular risk burden with risk of dementia and brain pathologies: A population-based cohort study.
Autorzy:: Song R; Department of Epidemiology and Biostatistics, School of Public Health, Tianjin Medical University, Tianjin, China.; Tianjin Key Laboratory of Environment, Nutrition and Public Health, Tianjin, China.; Center for International Collaborative Research on Environment, Nutrition and Public Health, Tianjin, China.
Pan KY; Department of Psychiatry, Amsterdam Public Health Research Institute, Amsterdam University Medical Center, Vrije Universiteit, Amsterdam, the Netherlands.
Xu H; Big Data and Engineering Research Center, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China.
Qi X; Department of Epidemiology and Biostatistics, School of Public Health, Tianjin Medical University, Tianjin, China.; Tianjin Key Laboratory of Environment, Nutrition and Public Health, Tianjin, China.; Center for International Collaborative Research on Environment, Nutrition and Public Health, Tianjin, China.
Buchman AS; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, USA.
Bennett DA; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, USA.
Xu W; Department of Epidemiology and Biostatistics, School of Public Health, Tianjin Medical University, Tianjin, China.; Tianjin Key Laboratory of Environment, Nutrition and Public Health, Tianjin, China.; Center for International Collaborative Research on Environment, Nutrition and Public Health, Tianjin, China.; Aging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.
Źródło:: Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2021 Dec; Vol. 17 (12), pp. 1914-1922. Date of Electronic Publication: 2021 Jul 26.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Język:: English
Imprint Name(s):: Publication: 2020- : Hoboken, NJ : John Wiley & Sons, Ltd.
Original Publication: Orlando, FL : Elsevier, Inc.
MeSH Terms:: Heart Disease Risk Factors*
Brain/*pathology
Dementia/*epidemiology
Aged ; Cohort Studies ; Female ; Humans ; Longitudinal Studies ; Male ; Risk Factors
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Grant Information:: R01 AG017917 United States AG NIA NIH HHS; UH2 NS100599 United States NS NINDS NIH HHS; UH2NS100599 United States NH NIH HHS; No. R01AG17917 United States NH NIH HHS
Contributed Indexing:: Keywords: Alzheimer's disease dementia; Framingham General Cardiovascular Risk Score; brain pathology; cohort study; dementia
Entry Date(s):: Date Created: 20210726 Date Completed: 20220210 Latest Revision: 20230922
Update Code:: 20240105
PubMed Central ID:: PMC10266491
DOI:: 10.1002/alz.12343
PMID:: 34310004
: Czasopismo naukowe

Introduction: The impact of cardiovascular risk burden on brain pathologies remains unclear. We aimed to examine the association of the Framingham General Cardiovascular Risk Score (FGCRS) with dementia risk, and brain pathologies.
Methods: Within the Rush Memory and Aging Project, 1588 dementia-free participants were assessed on FGCRS at baseline and followed up to 21 years. During the follow-up, 621 participants died and underwent autopsies.
Results: The multi-adjusted hazard ratios (HRs) (95% confidence intervals [CIs]) of FGCRS were 1.03 (1.00-1.07) for dementia and 1.04 (1.01-1.07) for Alzheimer's disease (AD) dementia. Further, a higher FGCRS was associated with higher gross chronic cerebral infarctions (odds ratio [OR] 1.08, 95% CI 1.02-1.14), cerebral atherosclerosis (OR 1.10, 95% CI 1.03-1.17), and global AD pathology (OR 1.06, 95% CI 1.01-1.12).
Conclusions: A higher FGCRS is associated with an increased risk of dementia and AD dementia. Both vascular and AD pathologies in the brain may underlie this association.
(© 2021 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.)

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