Synthesis of porphyrin-incorporating covalent organic frameworks for sonodynamic therapy.

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Tytuł:: Synthesis of porphyrin-incorporating covalent organic frameworks for sonodynamic therapy.
Autorzy:: Liu S; State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Science, Changchun 130022, P. R. China. .
Zhou Y
Hu C
Cai L
Liu Z
Pang M
Źródło:: Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2021 Aug 25; Vol. 57 (66), pp. 8178-8181. Date of Electronic Publication: 2021 Jul 27.
Typ publikacji:: Journal Article
Język:: English
Imprint Name(s):: Original Publication: Cambridge : Royal Society of Chemistry
MeSH Terms:: Ultrasonic Therapy*
Antineoplastic Agents/*pharmacology
Metal-Organic Frameworks/*pharmacology
Neoplasms/*therapy
Porphyrins/*pharmacology
Animals ; Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Drug Screening Assays, Antitumor ; Humans ; Metal-Organic Frameworks/chemical synthesis ; Metal-Organic Frameworks/chemistry ; Mice ; Molecular Structure ; Neoplasms/metabolism ; Neoplasms/pathology ; Optical Imaging ; Particle Size ; Porphyrins/chemistry ; Singlet Oxygen/chemistry ; Singlet Oxygen/metabolism ; Temperature
Substance Nomenclature:: 0 (Antineoplastic Agents)
0 (Metal-Organic Frameworks)
0 (Porphyrins)
17778-80-2 (Singlet Oxygen)
Entry Date(s):: Date Created: 20210728 Date Completed: 20210921 Latest Revision: 20210921
Update Code:: 20240105
DOI:: 10.1039/d1cc02902a
PMID:: 34318809
: Czasopismo naukowe

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Porphyrin-incorporating covalent organic frameworks were synthesized at room temperature. The resulting products with uniform morphology and excellent crystallinity exhibited good singlet oxygen generation ability. Both in vitro and in vivo experiments demonstrated the significant antitumor efficiency via sonodynamic therapy.

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