Recurrent assessment of lymphocyte subsets in 32 patients with multisystem inflammatory syndrome in children (MIS-C).

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Tytuł:: Recurrent assessment of lymphocyte subsets in 32 patients with multisystem inflammatory syndrome in children (MIS-C).
Autorzy:: Okarska-Napierała M; Department of Pediatrics with Clinical Assessment Unit, Medical University of Warsaw, Warsaw, Poland.
Mańdziuk J; Department of Pediatrics with Clinical Assessment Unit, Medical University of Warsaw, Warsaw, Poland.
Feleszko W; Department of Pediatric Pneumology and Allergy, Medical University of Warsaw, Warsaw, Poland.
Stelmaszczyk-Emmel A; Department of Laboratory Diagnostics and Clinical Immunology of Developmental Age, Medical University of Warsaw, Warsaw, Poland.
Panczyk M; Department of Education and Research in Health Sciences, Faculty of Health Sciences, Medical University of Warsaw, Warsaw, Poland.
Demkow U; Department of Laboratory Diagnostics and Clinical Immunology of Developmental Age, Medical University of Warsaw, Warsaw, Poland.
Kuchar E; Department of Pediatrics with Clinical Assessment Unit, Medical University of Warsaw, Warsaw, Poland.
Źródło:: Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology [Pediatr Allergy Immunol] 2021 Nov; Vol. 32 (8), pp. 1857-1865. Date of Electronic Publication: 2021 Aug 11.
Typ publikacji:: Journal Article
Język:: English
Imprint Name(s):: Publication: <2010->: Oxford, UK : Blackwell Publishing
Original Publication: Copenhagen : Munksgaard, c1990-
MeSH Terms:: Lymphocyte Subsets*
T-Lymphocyte Subsets*
Systemic Inflammatory Response Syndrome/*immunology
Cross-Sectional Studies ; Humans ; Lymphocyte Count ; Prospective Studies
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Contributed Indexing:: Keywords: COVID-19; MIS-C; PIMS-TS; cellular immunity; immune cells; prognostic markers; subsets
Entry Date(s):: Date Created: 20210731 Date Completed: 20211104 Latest Revision: 20220531
Update Code:: 20240105
DOI:: 10.1111/pai.13611
PMID:: 34331778
: Czasopismo naukowe

Pełny tekst

Background: Lymphopenia is a hallmark of multisystem inflammatory syndrome in children (MIS-C). We aimed to characterize lymphocyte subsets' shifts and their correlations with other severity markers of MIS-C.
Methods: In this prospective cross-sectional study, we performed peripheral lymphocyte phenotyping in 32 patients with MIS-C. We analyzed lymphocyte subsets at three time points of the disease: the acute (A), convalescent (B), and recovery (C) phases. Based on age-normalized lymphocyte counts, we distinguished two groups of patients: "the mild" (higher lymphocyte counts) and "the severe" (lower lymphocyte counts). In addition, we examined differences between these groups regarding other severity markers.
Results: In phase A, 84% of children had lymphopenia. Decreased absolute counts of CD3, CD4, and CD8 cells were observed in, respectively, 88%, 72%, and 84% of patients. The natural killer cells were decreased in 63% and CD19 in 59% of children. "The severe" group had significantly higher procalcitonin and troponin I levels and lower platelets and albumin. Moreover, "the severe" group had hypotension more frequently (73% vs. 20%, p = .008). In phase B, all lymphocyte counts increased, and 32% of children had lymphocytosis. The increase of CD3, CD4, and CD8 counts correlated with some laboratory severity markers (hemoglobin, procalcitonin, D-dimer, lactate dehydrogenase, N-terminal prohormone of brain natriuretic peptide, albumin), but not with steroid use. In phase C, most children had normal lymphocyte counts.
Conclusions: Substantial shifts in lymphocyte counts during MIS-C apply most to T lymphocytes and correlate with the disease severity markers, particularly hypotension prevalence. A proportion of children with MIS-C develops transient lymphocytosis during convalescence.
(© 2021 EAACI and John Wiley and Sons A/S. Published by John Wiley and Sons Ltd.)

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