Identification of an autophagy-related prognostic signature in head and neck squamous cell carcinoma.

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Tytuł:: Identification of an autophagy-related prognostic signature in head and neck squamous cell carcinoma.
Autorzy:: Jiang Y; Jiangsu Key Laboratory of Oral Disease, Nanjing Medical University, Jiangsu, China.
Li Y; Jiangsu Key Laboratory of Oral Disease, Nanjing Medical University, Jiangsu, China.
Ge H; Jiangsu Key Laboratory of Oral Disease, Nanjing Medical University, Jiangsu, China.
Wu Y; Department of Oral and Maxillofacial Surgery, Affiliated Hospital of Stomatology, Nanjing Medical University, Nanjing, China.
Zhang Y; Department of Oral and Maxillofacial Surgery, Affiliated Hospital of Stomatology, Nanjing Medical University, Nanjing, China.
Guo S; Department of Oral and Maxillofacial Surgery, Affiliated Hospital of Stomatology, Nanjing Medical University, Nanjing, China.
Zhang P; Department of Oral and Maxillofacial Surgery, Affiliated Hospital of Stomatology, Nanjing Medical University, Nanjing, China.
Cheng J; Jiangsu Key Laboratory of Oral Disease, Nanjing Medical University, Jiangsu, China.; Department of Oral and Maxillofacial Surgery, Affiliated Hospital of Stomatology, Nanjing Medical University, Nanjing, China.
Wang Y; Jiangsu Key Laboratory of Oral Disease, Nanjing Medical University, Jiangsu, China.
Źródło:: Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology [J Oral Pathol Med] 2021 Nov; Vol. 50 (10), pp. 1040-1049. Date of Electronic Publication: 2021 Aug 18.
Typ publikacji:: Journal Article
Język:: English
Imprint Name(s):: Publication: Oxford, UK : Wiley-Blackwell
Original Publication: Copenhagen : Munksgaard, c1989-
MeSH Terms:: Head and Neck Neoplasms*/diagnosis
Head and Neck Neoplasms*/genetics
Autophagy ; Biomarkers, Tumor/genetics ; Gene Expression Regulation, Neoplastic ; Humans ; Prognosis ; Squamous Cell Carcinoma of Head and Neck/genetics
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Grant Information:: NMUB2019071 Nanjing Medical University Science and Technology Development Funding Project; QNRC2016851 Qing-Lan Project and Jiangsu Young Medical Talent Projec; BE2020706 Key Research Program in Jiangsu Province-Social Developmental Project; 2018-87 A Project Funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions; 81572669 National Natural Science Foundation of China; 81602386 National Natural Science Foundation of China
Contributed Indexing:: Keywords: Head and neck squamous cell carcinoma; TCGA; autophagy-related genes; prognosis; signature
Substance Nomenclature:: 0 (Biomarkers, Tumor)
Entry Date(s):: Date Created: 20210806 Date Completed: 20211110 Latest Revision: 20211110
Update Code:: 20240105
DOI:: 10.1111/jop.13231
PMID:: 34358365
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Background: Autophagy-related genes (ARGs) have been significantly implicated in tumorigenesis and served as promising prognostic biomarkers for human cancer. Hence, this study was aimed to develop an ARGs-based prognostic signature for Head and neck squamous cell carcinoma (HNSCC).
Methods: Prognostic ARG candidates were identified by univariate and multivariate Cox regression analysis in the training dataset (TCGA-HNSC) and incorporated into a 3-ARGs (EGFR, FADD, and PARK2) prognostic signature which was further verified in two independent validation cohorts (GSE41613 and GSE42743). Kaplan-Meier plots, Cox regression analyses, and receiver operating characteristics curves (ROC) were employed to evaluate the prognostic prediction of 3-ARGs signature. Differential expression of these 3 ARG between cancer and normal counterparts as well as their associations with autophagy markers were assessed in 60 pairs of freshly collected HNSCC and adjacent non-tumor samples and datasets from Human Protein Atlas, respectively.
Results: Patients with high-risk score had significantly inferior overall survival. Multivariate regression analyses revealed that 3-ARGs signature could be an independent prognostic factor after adjusting various clinicopathological parameters. ROC analyses revealed high predictive accuracy and sensitivity of the 3-ARGs signature. Increased mRNA and protein expression of EGFR, FADD, and PARK2 were found in HNSCC samples, and their expression significantly correlated with the abundances of ATG5, Beclin1, and LC3.
Conclusion: Our results reveal that 3-ARGs signature is a powerful prognostic biomarker for HNSCC, which could be integrated into the current prognostic regime to realize individualized outcome prediction. EGFR, FADD, and PARK2 likely contributed to autophagy during HNSCC tumorigenesis.
(© 2021 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)

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