Generation of Hepatobiliary Cell Lineages from Human Induced Pluripotent Stem Cells: Applications in Disease Modeling and Drug Screening.

Tytuł:: Generation of Hepatobiliary Cell Lineages from Human Induced Pluripotent Stem Cells: Applications in Disease Modeling and Drug Screening.
Autorzy:: Pasqua M; Fondazione Ri.MED, 90133 Palermo, Italy.
Di Gesù R; Fondazione Ri.MED, 90133 Palermo, Italy.
Chinnici CM; Fondazione Ri.MED, 90133 Palermo, Italy.; Dipartimento della Ricerca, IRCCS ISMETT, 90127 Palermo, Italy.
Conaldi PG; Dipartimento della Ricerca, IRCCS ISMETT, 90127 Palermo, Italy.
Francipane MG; Fondazione Ri.MED, 90133 Palermo, Italy.; McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA 15219, USA.
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2021 Jul 30; Vol. 22 (15). Date of Electronic Publication: 2021 Jul 30.
Typ publikacji:: Journal Article; Review
Język:: English
Imprint Name(s):: Original Publication: Basel, Switzerland : MDPI, [2000-
MeSH Terms:: Cellular Reprogramming Techniques/*methods
Digestive System Diseases/*therapy
Drug Discovery/*methods
Hepatocytes/*cytology
Induced Pluripotent Stem Cells/*cytology
Precision Medicine/*methods
Animals ; Cell Lineage ; Digestive System Diseases/metabolism ; Digestive System Diseases/pathology ; Hepatocytes/metabolism ; Humans ; Tissue Engineering/methods
References:: J Cell Sci. 2004 Jul 1;117(Pt 15):3165-74. (PMID: 15226394)
Hepatology. 2016 Jul;64(1):277-86. (PMID: 26524612)
World J Stem Cells. 2019 Aug 26;11(8):535-547. (PMID: 31523372)
Exp Cell Res. 2019 May 15;378(2):217-225. (PMID: 30817927)
Stem Cell Rev Rep. 2020 Feb;16(1):3-32. (PMID: 31760627)
Ther Apher Dial. 2006 Apr;10(2):168-74. (PMID: 16684219)
Hepatology. 2018 Feb;67(2):750-761. (PMID: 28834615)
Biochim Biophys Acta Mol Basis Dis. 2019 May 1;1865(5):920-928. (PMID: 30264693)
Development. 2014 Jan;141(1):91-100. (PMID: 24284203)
Genomics Proteomics Bioinformatics. 2013 Oct;11(5):284-7. (PMID: 24121200)
Cell Stem Cell. 2018 Jul 05;23(1):114-122.e3. (PMID: 29937200)
Biosci Rep. 2015 Apr 28;35(2):. (PMID: 25797907)
Methods Mol Biol. 2019;1576:55-92. (PMID: 27628133)
Physiol Rev. 1989 Jul;69(3):708-64. (PMID: 2664826)
Stem Cells Transl Med. 2016 Sep;5(9):1257-67. (PMID: 27421950)
Tissue Eng Part A. 2016 Mar;22(5-6):449-60. (PMID: 26801816)
Compr Physiol. 2013 Jan;3(1):541-65. (PMID: 23720296)
Lab Invest. 2015 Jun;95(6):684-96. (PMID: 25867762)
Cell Rep. 2020 Jun 2;31(9):107711. (PMID: 32492423)
J Hepatol. 2003 Sep;39(3):357-64. (PMID: 12927921)
Hepatology. 2012 Dec;56(6):2163-71. (PMID: 22653811)
Hepatology. 1996 Mar;23(3):476-81. (PMID: 8617427)
Acta Biomater. 2017 Dec;64:67-79. (PMID: 28966094)
Biofabrication. 2020 Feb 19;12(2):025013. (PMID: 31929117)
Cell. 2006 Aug 25;126(4):663-76. (PMID: 16904174)
J Hepatol. 2019 Jun;70(6):1145-1158. (PMID: 30630011)
Nat Methods. 2016 Apr 28;13(5):405-14. (PMID: 27123816)
Hepatology. 2010 Jan;51(1):297-305. (PMID: 19998274)
Mol Ther. 2017 Jun 7;25(6):1420-1433. (PMID: 28462819)
Sci Rep. 2019 Sep 19;9(1):13557. (PMID: 31537830)
Methods Cell Biol. 2020;159:69-93. (PMID: 32586450)
Nat Rev Cancer. 2011 Apr;11(4):268-77. (PMID: 21390058)
J Cell Sci. 2012 Jul 1;125(Pt 13):3015-24. (PMID: 22797912)
Stem Cells Transl Med. 2013 Jul;2(7):505-9. (PMID: 23757504)
Curr Pathobiol Rep. 2016 Sep;4(3):77-85. (PMID: 28979828)
Hepatology. 2005 Mar;41(3):535-44. (PMID: 15726663)
Hepatology. 2004 Jun;39(6):1477-87. (PMID: 15185286)
Dev Cell. 2009 Jul;17(1):62-74. (PMID: 19619492)
Hepatology. 2015 Apr;61(4):1370-81. (PMID: 25421237)
Artif Cells Nanomed Biotechnol. 2020 Dec;48(1):218-229. (PMID: 31851840)
Front Cell Dev Biol. 2021 Feb 22;9:626805. (PMID: 33732695)
Nat Genet. 2004 Jan;36(1):83-7. (PMID: 14702043)
Nat Mater. 2010 Sep;9(9):768-78. (PMID: 20729850)
Hepatology. 2013 Jun;57(6):2458-68. (PMID: 23325555)
Proc Natl Acad Sci U S A. 2002 Nov 26;99(24):15655-60. (PMID: 12432097)
Stem Cells Dev. 2007 Aug;16(4):561-78. (PMID: 17784830)
Biomaterials. 2019 Feb;194:1-13. (PMID: 30562651)
Development. 2015 Feb 15;142(4):607-19. (PMID: 25670788)
Development. 1994 Jul;120(7):1919-28. (PMID: 7924997)
Hepatology. 2010 May;51(5):1754-65. (PMID: 20301097)
Biomaterials. 2018 May;165:94-104. (PMID: 29525265)
J Hepatol. 2015 Mar;62(3):581-9. (PMID: 25457200)
Annu Rev Pharmacol Toxicol. 1999;39:1-17. (PMID: 10331074)
Stem Cell Res Ther. 2018 Mar 9;9(1):58. (PMID: 29523187)
Arch Toxicol. 2015 Aug;89(8):1347-58. (PMID: 25107451)
Gastroenterology. 2020 Oct;159(4):1471-1486.e12. (PMID: 32553762)
Cell Stem Cell. 2017 Aug 3;21(2):159-160. (PMID: 28777941)
Drug Metab Dispos. 2014 Sep;42(9):1401-6. (PMID: 24980256)
Ann Biomed Eng. 2010 Jan;38(1):2-20. (PMID: 19816774)
Tissue Eng Part C Methods. 2010 Dec;16(6):1223-32. (PMID: 20184401)
Cell Transplant. 2006;15(4):335-41. (PMID: 16898227)
Cell Transplant. 2004;13(1):27-33. (PMID: 15040602)
Cell Stem Cell. 2014 Sep 4;15(3):340-349. (PMID: 25130492)
Pathology. 2008 Apr;40(3):272-6. (PMID: 18428047)
ACS Biomater Sci Eng. 2016 Sep 12;2(9):1649-1657. (PMID: 33440598)
Genes Dev. 2013 Apr 1;27(7):719-24. (PMID: 23520387)
Nature. 2011 Oct 12;478(7369):391-4. (PMID: 21993621)
Cell Res. 2009 Nov;19(11):1233-42. (PMID: 19736565)
Proc Natl Acad Sci U S A. 2012 Feb 14;109(7):2544-8. (PMID: 22308485)
Nat Biotechnol. 2015 Aug;33(8):845-852. (PMID: 26167629)
J Artif Organs. 2017 Dec;20(4):318-325. (PMID: 28776092)
Adv Funct Mater. 2020 Jun 8;30(48):2000893. (PMID: 34658689)
Expert Opin Drug Metab Toxicol. 2012 Jul;8(7):909-20. (PMID: 22568886)
Hepatol Commun. 2017 Nov;1(9):886-898. (PMID: 29130076)
Lab Chip. 2015 Oct 7;15(19):3822-37. (PMID: 26279012)
Nature. 2017 Jul 20;547(7663):350-354. (PMID: 28700576)
Curr Opin Genet Dev. 2015 Oct;34:54-60. (PMID: 26313850)
Int J Biochem Cell Biol. 2011 Feb;43(2):245-56. (PMID: 19735739)
Nat Biotechnol. 2005 Dec;23(12):1534-41. (PMID: 16258519)
Nat Rev Gastroenterol Hepatol. 2012 Feb 28;9(4):231-40. (PMID: 22371217)
Dev Cell. 2010 Feb 16;18(2):175-89. (PMID: 20159590)
Sci Rep. 2016 Nov 29;6:37427. (PMID: 27897167)
Cell Transplant. 2014;23(9):1045-59. (PMID: 23676629)
Stem Cells Dev. 2010 Sep;19(9):1427-36. (PMID: 20055663)
Hepatology. 1999 Dec;30(6):1425-33. (PMID: 10573521)
Ital J Anat Embryol. 2010;115(1-2):85-90. (PMID: 21072995)
Stem Cells Int. 2015;2015:794632. (PMID: 25922608)
Sci Rep. 2021 Mar 24;11(1):6772. (PMID: 33762604)
Semin Cancer Biol. 2005 Oct;15(5):405-12. (PMID: 16055341)
Stem Cell Reports. 2015 Apr 14;4(4):578-90. (PMID: 25843046)
Hepatology. 2014 Aug;60(2):700-14. (PMID: 24715669)
Development. 2015 Sep 15;142(18):3113-25. (PMID: 26395140)
Annu Rev Biomed Eng. 2011 Aug 15;13:27-53. (PMID: 21417722)
Am J Pathol. 1998 Mar;152(3):771-9. (PMID: 9502419)
Cell Med. 2011 Jun 01;2(1):9-25. (PMID: 26998399)
PLoS Pathog. 2012;8(4):e1002617. (PMID: 22496645)
Cell Stem Cell. 2018 Jul 5;23(1):11-12. (PMID: 29979985)
Stem Cell Reports. 2015 May 12;4(5):939-52. (PMID: 25937370)
J Clin Invest. 2011 Dec;121(12):4630-3. (PMID: 22105167)
Front Med (Lausanne). 2019 Nov 15;6:265. (PMID: 31803747)
Stem Cells. 2007 Jan;25(1):29-38. (PMID: 17204604)
Toxicol Sci. 2015 Jun;145(2):252-62. (PMID: 25716675)
Lab Invest. 2008 Aug;88(8):865-72. (PMID: 18574450)
Semin Liver Dis. 2002 Aug;22(3):227-40. (PMID: 12360417)
Cell Biol Toxicol. 2017 Aug;33(4):407-421. (PMID: 28144825)
Nat Med. 2017 Aug;23(8):954-963. (PMID: 28671689)
Stem Cell Res Ther. 2013;4 Suppl 1:S14. (PMID: 24565415)
Biochem Pharmacol. 2013 Sep 1;86(5):691-702. (PMID: 23856292)
J Clin Invest. 2014 Nov;124(11):4953-64. (PMID: 25295540)
Proc Natl Acad Sci U S A. 2014 Aug 19;111(33):12193-8. (PMID: 25092305)
Stem Cell Res Ther. 2021 Feb 25;12(1):151. (PMID: 33632328)
Mech Dev. 2003 Jan;120(1):117-30. (PMID: 12490302)
Food Chem Toxicol. 2020 Apr;138:111188. (PMID: 32045649)
Nat Cell Biol. 2015 Aug;17(8):971-983. (PMID: 26192438)
Elife. 2020 Mar 10;9:. (PMID: 32154783)
Gut Liver. 2016 Sep 15;10(5):687-98. (PMID: 27563020)
World J Gastroenterol. 2013 May 21;19(19):2841-6. (PMID: 23704818)
J Tissue Eng Regen Med. 2018 Apr;12(4):e1962-e1973. (PMID: 29222839)
Cell Transplant. 2017 Dec;26(12):1840-1854. (PMID: 29390876)
Biol Open. 2020 Dec 16;9(12):. (PMID: 33268331)
Connect Tissue Res. 2020 Mar;61(2):117-136. (PMID: 31524001)
Semin Liver Dis. 2001 Nov;21(4):525-34. (PMID: 11745040)
Nat Biotechnol. 2015 Aug;33(8):853-61. (PMID: 26167630)
J Hepatol. 2017 Mar;66(3):619-630. (PMID: 27826058)
J Hepatol. 2016 Jul;65(1):182-199. (PMID: 26916529)
PLoS One. 2014 Jun 20;9(6):e100417. (PMID: 24949734)
Toxicol Sci. 2015 Sep;147(1):39-54. (PMID: 26092927)
Dev Cell. 2001 Nov;1(5):605-17. (PMID: 11709181)
Exp Biol Med (Maywood). 2016 Sep;241(15):1684-98. (PMID: 27385595)
ACS Biomater Sci Eng. 2016 Dec 12;2(12):2255-2265. (PMID: 33465898)
Biotechnol Adv. 2017 Jan - Feb;35(1):77-94. (PMID: 28007615)
Am J Pathol. 2014 May;184(5):1468-78. (PMID: 24594350)
J Hepatol. 2019 Aug;71(2):344-356. (PMID: 30965071)
Hepatology. 2008 Aug;48(2):607-16. (PMID: 18666240)
Nature. 1993 Feb 11;361(6412):543-7. (PMID: 8429908)
Nature. 2018 May;557(7704):247-251. (PMID: 29720662)
Nat Protoc. 2011 Jun 23;6(7):1037-43. (PMID: 21720316)
Cytotechnology. 2015 Oct;67(5):793-807. (PMID: 24798808)
Tissue Eng Part A. 2020 Jun;26(11-12):613-622. (PMID: 31914890)
Stem Cells Int. 2016;2016:5481493. (PMID: 27057172)
Sci Rep. 2020 Sep 1;10(1):14349. (PMID: 32873852)
Contributed Indexing:: Keywords: cholangiocytes; disease modeling; drug testing; hepatocytes; iPSCs; tissue engineering
Entry Date(s):: Date Created: 20210807 Date Completed: 20210910 Latest Revision: 20231101
Update Code:: 20240105
PubMed Central ID:: PMC8348238
DOI:: 10.3390/ijms22158227
PMID:: 34360991
: Czasopismo naukowe

Pełny tekst

The possibility to reproduce key tissue functions in vitro from induced pluripotent stem cells (iPSCs) is offering an incredible opportunity to gain better insight into biological mechanisms underlying development and disease, and a tool for the rapid screening of drug candidates. This review attempts to summarize recent strategies for specification of iPSCs towards hepatobiliary lineages -hepatocytes and cholangiocytes-and their use as platforms for disease modeling and drug testing. The application of different tissue-engineering methods to promote accurate and reliable readouts is discussed. Space is given to open questions, including to what extent these novel systems can be informative. Potential pathways for improvement are finally suggested.

Zaloguj się, aby uzyskać dostęp do pełnego tekstu.

Informacja