Incidence of chronic respiratory conditions among oil spill responders: Five years of follow-up in the Deepwater Horizon Oil Spill Coast Guard Cohort study.

Szczegóły
Abstrakt

Tytuł:: Incidence of chronic respiratory conditions among oil spill responders: Five years of follow-up in the Deepwater Horizon Oil Spill Coast Guard Cohort study.
Autorzy:: Rusiecki JA; Department of Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Electronic address: .
Denic-Roberts H; Department of Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA; Oak Ridge Institute for Science and Education, MD, USA.
Thomas DL; United States Coast Guard Headquarters, Directorate of Health, Safety, and Work Life, Washington, D.C., USA.
Collen J; Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.
Barrett J; Department of Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.
Christenbury K; Social & Scientific Systems, a DLH Corporation Holding Company, Durham, NC, USA.
Engel LS; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA.
Źródło:: Environmental research [Environ Res] 2022 Jan; Vol. 203, pp. 111824. Date of Electronic Publication: 2021 Aug 05.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
Język:: English
Imprint Name(s):: Publication: <2000- > : Amsterdam : Elsevier
Original Publication: New York, Academic Press.
MeSH Terms:: Military Personnel*
Petroleum*
Petroleum Pollution*/adverse effects
Cohort Studies ; Follow-Up Studies ; Gulf of Mexico ; Humans ; Incidence
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Grant Information:: P30 ES010126 United States ES NIEHS NIH HHS; R01 ES020874 United States ES NIEHS NIH HHS
Contributed Indexing:: Keywords: Asthma; Crude oil; Dispersant; Long term respiratory disease; Oil spill; Responder
Substance Nomenclature:: 0 (Petroleum)
Entry Date(s):: Date Created: 20210808 Date Completed: 20211206 Latest Revision: 20230102
Update Code:: 20240105
PubMed Central ID:: PMC8616774
DOI:: 10.1016/j.envres.2021.111824
PMID:: 34364859
: Czasopismo naukowe

Background: Over ten years after the Deepwater Horizon (DWH) oil spill, our understanding of long term respiratory health risks associated with oil spill response exposures is limited. We conducted a prospective analysis in a cohort of U.S. Coast Guard personnel with universal military healthcare.
Methods: For all active duty cohort members (N = 45,193) in the DWH Oil Spill Coast Guard Cohort Study we obtained medical encounter data from October 01, 2007 to September 30, 2015 (i.e., ~2.5 years pre-spill; ~5.5 years post-spill). We used Cox Proportional Hazards regressions to calculate adjusted hazard ratios (aHR), comparing risks for incident respiratory conditions/symptoms (2010-2015) for: responders vs. non-responders; responders reporting crude oil exposure, any inhalation of crude oil vapors, and being in the vicinity of burning crude oil versus responders without those exposures. We also evaluated self-reported crude oil and oil dispersant exposures, combined. Within-responder comparisons were adjusted for age, sex, and smoking.
Results: While elevated aHRs for responder/non-responder comparisons were generally weak, within-responder comparisons showed stronger risks with exposure to crude oil. Notably, for responders reporting exposure to crude oil via inhalation, there were elevated risks for allsinusitis (aHR = 1.48; 95%CI, 1.06-2.06), unspecified chronic sinusitis (aHR = 1.55; 95%CI, 1.08-2.22), chronic obstructive pulmonary disease (COPD) and other allied conditions (aHR = 1.43; 95%CI, 1.00-2.06), and dyspnea and respiratory abnormalities (aHR = 1.29; 95%CI, 1.00-1.67); there was a suggestion of elevated risk for diseases classified as asthma and reactive airway diseases (aHR = 1.18; 95%CI, 0.98-1.41), including the specific condition, asthma (aHR = 1.35; 95%CI, 0.80-2.27), the symptom, shortness of breath (aHR = 1.50; 95%CI, 0.89-2.54), and the overall classification of chronic respiratory conditions (aHR = 1.18; 95%CI, 0.98-1.43). Exposure to both crude oil and dispersant was positively associated with elevated risk for shortness of breath (HR = 2.24; 95%CI, 1.09-4.64).
Conclusions: Among active duty Coast Guard personnel, oil spill clean-up exposures were associated with moderately increased risk for longer term respiratory conditions.
(Copyright © 2021 Elsevier Inc. All rights reserved.)

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