Obesity as a Risk Factor for Severe COVID-19: Summary of the Best Evidence and Implications for Health Care.

Szczegóły
Abstrakt

Tytuł:: Obesity as a Risk Factor for Severe COVID-19: Summary of the Best Evidence and Implications for Health Care.
Autorzy:: Sattar N; Institute of Cardiovascular and Medical Sciences, BHF Glasgow Cardiovascular Research Centre, University of Glasgow, 126 University Place, Glasgow, G12 8TA, UK. .
Valabhji J; NHS England & Improvement, London, UK.; Department of Diabetes and Endocrinology, St Mary's Hospital, Imperial College Healthcare NHS Trust, London, UK.; Division of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.
Źródło:: Current obesity reports [Curr Obes Rep] 2021 Sep; Vol. 10 (3), pp. 282-289. Date of Electronic Publication: 2021 Aug 10.
Typ publikacji:: Journal Article; Review
Język:: English
Imprint Name(s):: Original Publication: [Philadelphia, PA] : Current Medicine Group
MeSH Terms:: Body Mass Index*
Pandemics*
Severity of Illness Index*
COVID-19/*epidemiology
Obesity/*epidemiology
Adiposity ; Comorbidity ; Delivery of Health Care ; Humans ; Risk Factors ; SARS-CoV-2
References:: Diabet Med. 2018 Apr;35(4):513-518. (PMID: 29266374)
Circulation. 2021 Apr 27;143(17):1655-1658. (PMID: 33900834)
N Engl J Med. 2020 Oct 15;383(16):1535-1543. (PMID: 33053284)
Circulation. 2020 Jul 7;142(1):4-6. (PMID: 32320270)
Eur Heart J. 2020 Jan 7;41(2):221-226. (PMID: 31195408)
JMIR Mhealth Uhealth. 2019 May 10;7(5):e12326. (PMID: 31094352)
Diabetes Care. 2020 Jan;43(1):152-160. (PMID: 31719054)
Lancet Diabetes Endocrinol. 2021 Jun;9(6):350-359. (PMID: 33932335)
BMJ. 2020 Oct 20;371:m3731. (PMID: 33082154)
Nat Med. 2020 Mar;26(3):320-325. (PMID: 32152584)
Int J Environ Res Public Health. 2021 Feb 15;18(4):. (PMID: 33671943)
JAMA. 2015 Jul 7;314(1):52-60. (PMID: 26151266)
Infection. 2015 Oct;43(5):569-75. (PMID: 26148927)
Crit Care. 2017 Feb 22;21(1):36. (PMID: 28222804)
Lancet. 2018 Feb 10;391(10120):541-551. (PMID: 29221645)
Horm Metab Res. 2021 Feb;53(2):85-93. (PMID: 33395706)
Proc Natl Acad Sci U S A. 2021 Feb 23;118(8):. (PMID: 33563754)
Lancet. 2011 Oct 22;378(9801):1485-92. (PMID: 21906798)
Clin Obes. 2021 Aug;11(4):e12453. (PMID: 33855789)
PLoS Med. 2021 Mar 4;18(3):e1003553. (PMID: 33661905)
Surg Obes Relat Dis. 2021 Jan;17(1):208-214. (PMID: 33243670)
Lancet. 2018 Nov 17;392(10160):2180-2193. (PMID: 30293770)
Nature. 2020 Aug;584(7821):430-436. (PMID: 32640463)
BMJ. 2021 Mar 10;372:n254. (PMID: 33692200)
Obes Rev. 2020 Nov;21(11):e13089. (PMID: 32929833)
Lancet Diabetes Endocrinol. 2020 May;8(5):447-455. (PMID: 32333880)
Lancet. 2016 Aug 20;388(10046):776-86. (PMID: 27423262)
Diabetes Care. 2020 Jun;43(6):1276-1284. (PMID: 32152136)
Am J Clin Nutr. 2021 Apr 6;113(4):924-938. (PMID: 33675635)
N Engl J Med. 2021 Mar 18;384(11):989. (PMID: 33567185)
Lancet Diabetes Endocrinol. 2020 Oct;8(10):823-833. (PMID: 32798471)
Diabetes Metab Syndr. 2020 Sep - Oct;14(5):1149-1151. (PMID: 32668401)
Contributed Indexing:: Keywords: Activity; Body mass Index; Diet; Epidemiology; Genetics; Multimorbidity
Entry Date(s):: Date Created: 20210810 Date Completed: 20210910 Latest Revision: 20220218
Update Code:: 20240105
PubMed Central ID:: PMC8353061
DOI:: 10.1007/s13679-021-00448-8
PMID:: 34374955
: Czasopismo naukowe

Full Text Finder

Purpose of Review: To collate the best evidence from several strands-epidemiological, genetic, comparison with historical data and mechanistic information-and ask whether obesity is an important causal and potentially modifiable risk factor for severe COVID-19 outcomes.
Recent Findings: Several hundred studies provide powerful evidence that body mass index (BMI) is a strong linear risk factor for severe COVID-19 outcomes, with recent studies suggesting ~5-10% higher risk for COVID-19 hospitalisation per every kg/m 2 higher BMI. Genetic data concur with hazard ratios increasing by 14% per every kg/m 2 higher BMI. BMI to COVID-19 links differ markedly from prior BMI-infection associations and are further supported as likely causal by multiple biologically plausible pathways. Excess adiposity appears to be an important, modifiable risk factor for adverse COVID-19 outcomes across all ethnicities. The pandemic is also worsening obesity levels. It is imperative that medical systems worldwide meet this challenge by upscaling investments in obesity prevention and treatments.
(© 2021. The Author(s).)

Informacja