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Tytuł:
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Intact Proactive Motor Inhibition after Unilateral Prefrontal Cortex or Basal Ganglia Lesions.
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Autorzy:
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Liebrand M; University of Lübeck, Germany.
Solbakk AK; University of Oslo, Norway.; Oslo University Hospital, Norway.; Helgeland Hospital, Mosjøen, Norway.
Funderud I; University of Oslo, Norway.; Helgeland Hospital, Mosjøen, Norway.
Buades-Rotger M; University of Lübeck, Germany.; Radboud University, Nijmegen, The Netherlands.
Knight RT; University of California, Berkeley.
Krämer UM; University of Lübeck, Germany.
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Źródło:
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Journal of cognitive neuroscience [J Cogn Neurosci] 2021 Aug 01; Vol. 33 (9), pp. 1862-1879.
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Typ publikacji:
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Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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Język:
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English
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Imprint Name(s):
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Original Publication: Cambridge, Mass. : Published by the MIT Press with the Cognitive Neuroscience Institute, c1989-
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MeSH Terms:
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Inhibition, Psychological*
Prefrontal Cortex*
Attention ; Basal Ganglia ; Humans ; Proactive Inhibition ; Reaction Time ; Reactive Inhibition
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Grant Information:
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NS21135 United States NS NINDS NIH HHS
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Entry Date(s):
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Date Created: 20210810 Date Completed: 20211104 Latest Revision: 20230602
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Update Code:
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20240105
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DOI:
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10.1162/jocn_a_01691
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PMID:
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34375417
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Previous research provided evidence for the critical importance of the PFC and BG for reactive motor inhibition, that is, when actions are cancelled in response to external signals. Less is known about the role of the PFC and BG in proactive motor inhibition, referring to preparation for an upcoming stop signal. In this study, patients with unilateral lesions to the BG or lateral PFC performed in a cued go/no-go task, whereas their EEG was recorded. The paradigm called for cue-based preparation for upcoming, lateralized no-go signals. Based on previous findings, we focused on EEG indices of cognitive control (prefrontal beta), motor preparation (sensorimotor mu/beta, contingent negative variation [CNV]), and preparatory attention (occipital alpha, CNV). On a behavioral level, no differences between patients and controls were found, suggesting an intact ability to proactively prepare for motor inhibition. Patients showed an altered preparatory CNV effect, but no other differences in electrophysiological activity related to proactive and reactive motor inhibition. Our results suggest a context-dependent role of BG and PFC structures in motor inhibition, being critical in reactive, unpredictable contexts, but less so in situations where one can prepare for stopping on a short timescale.
(© 2021 Massachusetts Institute of Technology.)
