Aspects of intercellular communication in bone and implications in therapy.

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Tytuł:: Aspects of intercellular communication in bone and implications in therapy.
Autorzy:: John Martin T; St Vincent's Institute of Medical Research, The University of Melbourne Department of Medicine at St Vincent's Hospital, Fitzroy, Victoria 3065, Australia. Electronic address: .
Źródło:: Bone [Bone] 2021 Dec; Vol. 153, pp. 116148. Date of Electronic Publication: 2021 Aug 11.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
Język:: English
Imprint Name(s):: Publication: New York : Elsevier Science
Original Publication: Elmsford, NY : Pergamon Press, c1985-
MeSH Terms:: Bone Resorption*
Cell Communication*
Osteoclasts*
Bone and Bones ; Humans ; Osteoblasts ; RANK Ligand
Contributed Indexing:: Keywords: Bone formation; Bone remodelling; Bone resorption; Coupling; Osteoblasts; Osteoclasts; Osteoporosis
Substance Nomenclature:: 0 (RANK Ligand)
Entry Date(s):: Date Created: 20210814 Date Completed: 20211025 Latest Revision: 20220531
Update Code:: 20240105
DOI:: 10.1016/j.bone.2021.116148
PMID:: 34389478
: Czasopismo naukowe

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Communication processes among the cells of bone are essential for the structure and function of the organ. After it was proposed that communication from the osteoblast lineage to hemopoietic cells initiated osteoclastogenesis, the molecular controls were identified to be the tumour necrosis factor ligand and receptor families. This was followed by revelation of very many signalling processes among the cells of bone that regulate the three phases of bone remodelling, the resorption, reversal and formation phases. In many instances the ways in which these mechanisms operate can determine how drugs act on bone, whether they be inhibitors of resorption or promoters of formation.
(Copyright © 2021 Elsevier Inc. All rights reserved.)

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