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Tytuł:
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Lactic acid in tumor invasion.
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Autorzy:
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Niu D; Institute of Pharmacy and Pharmacology, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, Hunan Provincial Key Laboratory of Tumor Microenvironment Responsive Drug Research, University of South China, Hengyang 421001, China.
Luo T; Institute of Pharmacy and Pharmacology, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, Hunan Provincial Key Laboratory of Tumor Microenvironment Responsive Drug Research, University of South China, Hengyang 421001, China.
Wang H; Institute of Pharmacy and Pharmacology, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, Hunan Provincial Key Laboratory of Tumor Microenvironment Responsive Drug Research, University of South China, Hengyang 421001, China.
Xia Y; Institute of Pharmacy and Pharmacology, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, Hunan Provincial Key Laboratory of Tumor Microenvironment Responsive Drug Research, University of South China, Hengyang 421001, China.
Xie Z; Institute of Pharmacy and Pharmacology, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, Hunan Provincial Key Laboratory of Tumor Microenvironment Responsive Drug Research, University of South China, Hengyang 421001, China. Electronic address: .
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Źródło:
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Clinica chimica acta; international journal of clinical chemistry [Clin Chim Acta] 2021 Nov; Vol. 522, pp. 61-69. Date of Electronic Publication: 2021 Aug 13.
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Typ publikacji:
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Journal Article; Review
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Język:
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English
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Imprint Name(s):
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Original Publication: Amsterdam, Elsevier.
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MeSH Terms:
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Epithelial-Mesenchymal Transition*
Lactic Acid*
Cell Line, Tumor ; Cell Movement ; Humans ; Neoplasm Invasiveness ; Signal Transduction ; Transforming Growth Factor beta
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Contributed Indexing:
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Keywords: Basement membrane remodeling; Epithelial-mesenchymal transition; Lactic acid; Tumor invasion
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Substance Nomenclature:
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0 (Transforming Growth Factor beta)
33X04XA5AT (Lactic Acid)
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Entry Date(s):
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Date Created: 20210817 Date Completed: 20210928 Latest Revision: 20210928
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Update Code:
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20240104
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DOI:
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10.1016/j.cca.2021.08.011
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PMID:
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34400170
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Invasion involves tumor cells altering their cell-matrix interactions and acquiring motility for metastatic spread. Invasive tumor cells exhibit dysregulated metabolism and enhanced aerobic glycolysis, leading to nutrient depletion, hypoxia, and lactic acid production. Lactic acid is a byproduct of glycolysis capable of promoting oncogenic progression, but its role in tumor invasion is unclear. A growing number of studies have demonstrated that lactic acid regulates the degradation of collagen Ⅳ, collagen Ⅶ, and glycoprotein; the synthesis of collagen Ⅰ; and multiple signaling pathways, including TGF-β/Smad, Wnt/β-catenin, IL-6/STAT3, and HGF/MET, which are associated with basement membrane (BM) remodeling and epithelial-mesenchymal transition (EMT), two hallmarks of the tumor invasive process. In the present review, we summarize BM remodeling and EMT in tumor invasion, discuss the emerging roles and molecular mechanisms of lactic acid in these processes, and provide insights for further research.
(Copyright © 2021 Elsevier B.V. All rights reserved.)
