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Tytuł pozycji:

Steroid Phobia: Is There a Basis? A Review of Topical Steroid Safety, Addiction and Withdrawal.

Tytuł:
Steroid Phobia: Is There a Basis? A Review of Topical Steroid Safety, Addiction and Withdrawal.
Autorzy:
Tan SY; Division of Dermatology, Department of Medicine, National University Hospital, 5 Lower Kent Ridge Road, Singapore, 119074, Singapore.
Chandran NS; Division of Dermatology, Department of Medicine, National University Hospital, 5 Lower Kent Ridge Road, Singapore, 119074, Singapore. nisha_suyien_.; Department of Medicine, Yong Loo Lin School of Medicine, National University Singapore, 10 Medical Dr, Singapore, 117597, Singapore. nisha_suyien_.
Choi EC; Division of Dermatology, Department of Medicine, National University Hospital, 5 Lower Kent Ridge Road, Singapore, 119074, Singapore.
Źródło:
Clinical drug investigation [Clin Drug Investig] 2021 Oct; Vol. 41 (10), pp. 835-842. Date of Electronic Publication: 2021 Aug 18.
Typ publikacji:
Journal Article; Review
Język:
English
Imprint Name(s):
Publication: Auckland : Adis, Springer International
Original Publication: Mairangi Bay, Auckland, N.Z. ; Philadelphia : Adis International, c1995-
MeSH Terms:
Phobic Disorders*
Steroids*
Humans
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Substance Nomenclature:
0 (Steroids)
Entry Date(s):
Date Created: 20210819 Date Completed: 20211001 Latest Revision: 20220303
Update Code:
20240104
PubMed Central ID:
PMC8481181
DOI:
10.1007/s40261-021-01072-z
PMID:
34409577
Czasopismo naukowe
There is a growing concern amongst patients about topical corticosteroid (TCS) side effects, with increasing discussion of topical steroid addiction (TSA) and topical steroid withdrawal (TSW) particularly on social media platforms. However, the acceptance of TSA/TSW as a distinct condition remains controversial within the dermatological community. We conducted a literature search using PubMed, MEDLINE, Cochrane Library, Google Scholar, Embase and Web of Science to identify original articles addressing TSA/TSW. We described the definition and reported clinical features of TSA/TSW including its classification into erythemato-edematous and papulopustular subtype. To assess the validity of TSA/TSW, we summarised and objectively appraised the postulated mechanisms for this condition, including tachyphylaxis, dysregulation of glucocorticoid receptors, rebound vasodilation and impaired skin barrier leading to a cytokine cascade. Understanding the evidence including its limitations and uncertainties highlights areas for future research and helps medical practitioners better counsel and provide care to patients who may be experiencing or who have concerns about TSA/TSW.
(© 2021. The Author(s).)

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