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Tytuł pozycji:

Chagas disease is not associated with diabetes, metabolic syndrome, insulin resistance and beta cell dysfunction at baseline of Brazilian Longitudinal Study of Adult Health (ELSA-Brasil).

Tytuł:
Chagas disease is not associated with diabetes, metabolic syndrome, insulin resistance and beta cell dysfunction at baseline of Brazilian Longitudinal Study of Adult Health (ELSA-Brasil).
Autorzy:
Resende BAM; Internal Medicine Department, Faculty of Medicine, Faculdade Atenas, Sete Lagoas, Minas Gerais, Brazil.
Beleigoli AMR; College of Nursing and Health Sciences, Flinders University, Adelaide, South Australia, Australia.
Ribeiro ALP; Internal Medicine Department, Faculty of Medicine, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Duncan B; Postgraduate Program in Epidemiology and Hospital de Clínicas de Porto Alegre, Federal University of Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil.
Schmidt MI; Postgraduate Program in Epidemiology and Hospital de Clínicas de Porto Alegre, Federal University of Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil.
Mill JG; Department of Physiological Sciences, Federal University of Espirito Santo, Vitória, Espírito Santo, Brazil.
Goulart AC; Hospital Universitário, Universidade de São Paulo, São Paulo, São Paulo, Brazil.
Pereira ADC; Laboratorio de Genetica e Cardiologia Molecular, Instituto do Coração, Faculdade de Medicina da Universidade de São Paulo, São Paulo, São Paulo, Brazil.
Barreto SM; Public Health Department, Faculty of Medicine, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Diniz MFHS; Internal Medicine Department, Faculty of Medicine, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil. Electronic address: .
Źródło:
Parasitology international [Parasitol Int] 2021 Dec; Vol. 85, pp. 102440. Date of Electronic Publication: 2021 Aug 17.
Typ publikacji:
Journal Article
Język:
English
Imprint Name(s):
Original Publication: Amsterdam ; New York : Elsevier, c1997-
MeSH Terms:
Insulin Resistance*
Chagas Disease/*epidemiology
Diabetes Mellitus, Type 2/*epidemiology
Insulin-Secreting Cells/*pathology
Metabolic Syndrome/*epidemiology
Adult ; Aged ; Brazil/epidemiology ; Chagas Disease/complications ; Cross-Sectional Studies ; Diabetes Mellitus, Type 2/complications ; Female ; Humans ; Incidence ; Longitudinal Studies ; Male ; Metabolic Syndrome/complications ; Middle Aged ; Prevalence
Contributed Indexing:
Keywords: Chagas cardiomiopathy; Chagas disease; Diabetes mellitus; Insulin resistance, metabolic syndrome
Entry Date(s):
Date Created: 20210819 Date Completed: 20211028 Latest Revision: 20211028
Update Code:
20240104
DOI:
10.1016/j.parint.2021.102440
PMID:
34411740
Czasopismo naukowe
Chagas disease (ChD) affects millions of people worldwide, being endemic in Latin America and emerging in the United States and Europe. Classically described as targeting the heart and gastrointestinal tract, Trypanosoma cruzi parasitism leads to structural and pro-inflammatory changes in the adipose tissue and pancreas. The effects of these changes on insulin resistance (IR), beta cell dysfunction, diabetes mellitus (DM),and metabolic syndrome (MS) are unclear. We aim to evaluate the association of ChD with DM, IR, beta cell dysfunction and MS in the baseline of multi-centric cohort study 'Brazilian Longitudinal Study of Adult Health' (ELSA-Brasil). This cross-sectional analysis included 14,922 (98%) participants of ELSA-Brasil at baseline. To investigate the associations of ChD with DM, IR (assessed by HOMA-IR) and beta cell dysfunction (assessed by HOMA beta), and MS we fitted logistic regression models including socio-demographic and anthropometric variables, health-related conditions and laboratory results. ChD, defined by positive serology, was prevalent in 1.9% (n = 283) of the sample, 17.3% (n = 49) of whom had cardiomyopathy. DM prevalence was 17.25% (n = 2574) and was not different among those with and without ChD (20.5% vs 17.2%; p = 0.28). Fasting and 2 h-blood glucose after a 75 g anhydrous glucose were slightly higher among participants positive for ChD, when compared with those with negative serology (102 mg/dL versus 100 mg/dL, respectively; and 127 mg/dL versus 124 mg/dL, respectively), only in univariate analysis. There was no significant association between these variables and ChD after adjustments. In addition, there was no significant association between DM, IR, beta cell dysfunction or MS and ChD (without and with cardiomyopathy). Our results showed that ChD, regardless of the presence of cardiomyopathy, is not associated with DM, IR, beta cell dysfunction or MS. These findings suggest the parasitism of the adipose tissue and pancreas in Chagas disease do not translate into clinically relevant glucose abnormalities.
(Copyright © 2021 Elsevier B.V. All rights reserved.)

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