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Tytuł pozycji:

Demonstrating the feasibility of accurately and reliably correcting potassium results for mildly hemolytic samples using a new experimental design.

Tytuł:
Demonstrating the feasibility of accurately and reliably correcting potassium results for mildly hemolytic samples using a new experimental design.
Autorzy:
van Rossum HH; Department of Laboratory Medicine, The Netherlands Cancer Institute, Amsterdam, the Netherlands. Electronic address: .
Źródło:
Clinica chimica acta; international journal of clinical chemistry [Clin Chim Acta] 2021 Nov; Vol. 522, pp. 83-87. Date of Electronic Publication: 2021 Aug 18.
Typ publikacji:
Journal Article
Język:
English
Imprint Name(s):
Original Publication: Amsterdam, Elsevier.
MeSH Terms:
Hemolysis*
Potassium*
Feasibility Studies ; Humans ; Reproducibility of Results ; Research Design
Contributed Indexing:
Keywords: Hemolytic index; In vitro hemolysis; Potassium; Reporting algorithm
Substance Nomenclature:
RWP5GA015D (Potassium)
Entry Date(s):
Date Created: 20210821 Date Completed: 20210928 Latest Revision: 20210928
Update Code:
20240104
DOI:
10.1016/j.cca.2021.08.019
PMID:
34418365
Czasopismo naukowe
Background and Aims: For several decades, there has been an ongoing debate about the appropriateness and reliability of correcting potassium concentration results for hemolyzed samples. As part of implementing a new Roche Cobas Pro analyzer system the possibility of correcting potassium results in hemolytic samples using a new, thorough experimental design, was investigated.
Materials and Methods: The relationship between hemolytic index (HI) and increases in potassium concentration was studied by performing a linear regression on hemolysate dilution series (HI 0-160 mg/dL) from 20 left-over patient samples. The obtained correction procedure was validated using another 20 left-over patient samples. Corrections were accepted according to a correction concordance of 100% within the total allowable error criterion of 4.85%.
Results: The obtained reporting procedure was: HI 0-17 quantitative potassium reporting, HI 18-100 correct potassium for HI, and report as text including a disclaimer for in vivo hemolysis; samples were rejected for HI > 100. In the validation cohort, 70/70 samples eligible for correction were within the TEa criterion. The maximum negative and positive errors were -2.8% and 2.9%, respectively.
Conclusion: Correcting potassium concentration results in a designated HI range is feasible and increases the accuracy the potassium results in samples with mild in vitro hemolysis.
(Copyright © 2021. Published by Elsevier B.V.)

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