Pancreatic enzyme autodigestion of an unresectable retroperitoneal liposarcoma.

Szczegóły
Abstrakt

Tytuł:: Pancreatic enzyme autodigestion of an unresectable retroperitoneal liposarcoma.
Autorzy:: Zeh R; The Ohio State University Wexner Medical Center, Columbus, Ohio, USA.
Wiseman J; Department of Surgery, Division of Surgical Oncology, Ohio State University Wexner Medical Center, Columbus, Ohio, USA.
Liebner D; Department of Medicine, Division of Medical Oncology, Ohio State University Wexner Medical Center, Columbus, Ohio, USA.
Grignol V; Department of Surgery, Division of Surgical Oncology, Ohio State University Wexner Medical Center, Columbus, Ohio, USA .
Źródło:: BMJ case reports [BMJ Case Rep] 2021 Aug 23; Vol. 14 (8). Date of Electronic Publication: 2021 Aug 23.
Typ publikacji:: Case Reports; Journal Article
Język:: English
Imprint Name(s):: Original Publication: London : BMJ Pub. Group
MeSH Terms:: Liposarcoma*/diagnostic imaging
Liposarcoma*/surgery
Retroperitoneal Neoplasms*/diagnostic imaging
Retroperitoneal Neoplasms*/surgery
Aged ; Humans ; Male ; Pancreaticoduodenectomy ; Retroperitoneal Space
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Contributed Indexing:: Keywords: oncology; surgery; surgical oncology
SCR Disease Name:: Retroperitoneal liposarcoma
Entry Date(s):: Date Created: 20210824 Date Completed: 20210825 Latest Revision: 20230824
Update Code:: 20240105
PubMed Central ID:: PMC8383868
DOI:: 10.1136/bcr-2021-243194
PMID:: 34426422
: Czasopismo naukowe

This is a case of a 71-year-old man who had multiple synchronous retroperitoneal liposarcoma (LPS) foci composed of both well-differentiated and dedifferentiated histologies. In addressing this, the patient underwent a margin negative resection of a 11.8×8.8 cm right-sided dedifferentiated LPS requiring pancreaticoduodenectomy; however, a 13.1×7.2 cm left-sided well-differentiated LPS (WDLPS) was not resected due to its involvement of the proximal mesenteric vessels. The patient's postoperative course was complicated by grade B postoperative pancreatic fistula involving the anatomical territory of the residual WDLPS. Over the next 12 months, serial CT scans demonstrated a stepwise reduction in size of the WDLPS until it completely regressed. The authors hypothesise that enzymes shed from the pancreatic fistula initiated the autodigestion and subsequent necrosis of the WDLPS with associated tumour regression.
Competing Interests: Competing interests: None declared.
(© BMJ Publishing Group Limited 2021. No commercial re-use. See rights and permissions. Published by BMJ.)

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