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Tytuł:
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The high platelet counts as predictor for early foetal demise.
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Autorzy:
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Shao X; Department of Obstetrics and Gynecology, Tongji University School of Medicine, Shanghai Tenth People's Hospital, Shanghai, China.
Wang D; Department of Obstetrics and Gynecology, Tongji University School of Medicine, Shanghai Tenth People's Hospital, Shanghai, China.; School of Life Sciences and Technology, Tongji University, Shanghai, China.
Xu Y; School of Life Sciences and Technology, Tongji University, Shanghai, China.
Guo L; Department of Obstetrics and Gynecology, Tongji University School of Medicine, Shanghai Tenth People's Hospital, Shanghai, China.
Yang H; Department of Reproductive Medicine Center, Tongji University School of Medicine, Shanghai East Hospital, Shanghai, China.
Zhou J; Department of Health Management, Tongji University School of Medicine, Shanghai East Hospital, Shanghai, China.
Liang J; School of Mathematics and Statistics, University of Glasgow, Glasgow, UK.
Qian J; School of Life Sciences and Technology, Tongji University, Shanghai, China.
Cheng J; Department of Obstetrics and Gynecology, Tongji University School of Medicine, Shanghai Tenth People's Hospital, Shanghai, China.
Sun L; Department of Reproductive Medicine Center, Tongji University School of Medicine, Shanghai East Hospital, Shanghai, China.
Xiang Y; Department of Obstetrics and Gynecology, Tongji University School of Medicine, Shanghai Tenth People's Hospital, Shanghai, China.; School of Life Sciences and Technology, Tongji University, Shanghai, China.; Department of Reproductive Medicine Center, Tongji University School of Medicine, Shanghai East Hospital, Shanghai, China.
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Źródło:
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Annals of medicine [Ann Med] 2021 Dec; Vol. 53 (1), pp. 1502-1508.
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Typ publikacji:
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Journal Article; Research Support, Non-U.S. Gov't
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Język:
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English
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Imprint Name(s):
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Publication: London : Informa Healthcare
Original Publication: Helsinki : Finnish Medical Society Duodecim, 1989-
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MeSH Terms:
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Fetal Death*
Platelet Count*
Ultrasonography, Prenatal*
Fetal Heart/*diagnostic imaging
Gestational Sac/*diagnostic imaging
Pregnancy/*blood
Pregnancy Complications/*blood
Adult ; Case-Control Studies ; China/epidemiology ; Female ; Fetal Heart/embryology ; Humans ; Pregnancy Trimester, First ; Time Factors
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References:
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Arterioscler Thromb Vasc Biol. 2011 May;31(5):1215-8. (PMID: 21330610)
Fertil Steril. 1996 Mar;65(3):503-9. (PMID: 8774277)
Haematologica. 2011 Aug;96(8):1180-8. (PMID: 21546503)
Fertil Steril. 2004 Sep;82(3):735-7. (PMID: 15374723)
Int J Cardiol. 2014 Aug 20;175(3):433-40. (PMID: 25017904)
BMJ. 2013 Jun 19;346:f3676. (PMID: 23783355)
Am J Obstet Gynecol. 2015 Feb;212(2):125-6. (PMID: 25634040)
Science. 2010 Apr 30;328(5978):562-4. (PMID: 20430990)
BMJ. 2019 Mar 20;364:l869. (PMID: 30894356)
Paediatr Perinat Epidemiol. 2018 Jan;32(1):19-29. (PMID: 29053188)
Am J Hematol. 2019 Jan;94(1):E8-E11. (PMID: 30328633)
J Lab Clin Med. 1983 Feb;101(2):295-307. (PMID: 6822764)
Hum Reprod. 2005 Nov;20(11):3008-11. (PMID: 16006453)
J Clin Invest. 1966 May;45(5):645-57. (PMID: 5327481)
Lancet. 2018 Feb 21;391 Suppl 2:S34. (PMID: 29553433)
N Engl J Med. 2018 Jul 05;379(1):32-43. (PMID: 29972751)
Ginekol Pol. 2020;91(4):210-215. (PMID: 32374021)
Nature. 2017 Apr 6;544(7648):105-109. (PMID: 28329764)
Blood. 2016 Jan 14;127(2):179-80. (PMID: 26769773)
Nat Rev Cardiol. 2019 Mar;16(3):166-179. (PMID: 30429532)
Thromb Haemost. 2015 Nov 25;114(6):1299-309. (PMID: 26245769)
Ultrasound Obstet Gynecol. 1996 Mar;7(3):170-3. (PMID: 8705407)
Blood. 2012 Aug 23;120(8):1552-61. (PMID: 22665937)
Blood. 2016 Jan 14;127(2):251-9. (PMID: 26518434)
Thromb Diath Haemorrh. 1974 May 15;31(2):363-5. (PMID: 4852669)
J Thromb Haemost. 2010 Jan;8(1):157-62. (PMID: 19496920)
J Thromb Haemost. 2011 Jan;9(1):49-56. (PMID: 20942852)
J Thromb Haemost. 2010 Jan;8(1):148-56. (PMID: 19691485)
Br J Haematol. 2002 May;117(2):399-404. (PMID: 11972524)
Clin Pharmacokinet. 2012 Jun 1;51(6):365-96. (PMID: 22515555)
N Engl J Med. 1988 Jul 28;319(4):189-94. (PMID: 3393170)
Nat Commun. 2012 May 22;3:852. (PMID: 22617292)
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Contributed Indexing:
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Keywords: Pregnancy; early foetal demise; mean platelet volume; platelet counts
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Entry Date(s):
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Date Created: 20210825 Date Completed: 20211227 Latest Revision: 20231102
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Update Code:
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20240104
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PubMed Central ID:
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PMC8405072
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DOI:
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10.1080/07853890.2021.1968027
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PMID:
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34431412
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Objectives: Early fetal demise (absence of cardiac activity in a visible fetus) is a very common event, but there are no reliable biomarkers to predict it. The purpose of the study was to assess the association of platelet parameters with early fetal demise. Methods: In this case-control study, we included women with normal deliveries or those ultrasound diagnosed as early fetal demise. For those who were identified with early fetal demise, the platelet parameters were analyzed before the ultrasound diagnosis, which is based on the absence of either an embryo within a gestational sac or cardiac activity in a visible embryo in the 5-10 weeks of gestation. The association between the risk of early fetal demise with the women's mean platelet volume (MPV) and platelet counts was calculated by logistic regression. Duplicate measurements of platelet aggregation were performed with VerifyNow. Results: In total, 99 women identified with early fetal demise and 170 women who had an uncomplicated pregnancy with normal delivery from January 2017 and August 2020 were included in the study. We found that platelet counts in the early fetal demise group were significantly higher than healthy pregnancies. In addition, platelet reactivity is higher in the normal delivery group than those in early fetal demise group ( p < .05). High levels of platelet counts resulted in an adjusted odds ratio (OR) of 2.075 (95% confidence interval [95% CI], 1.215-3.544; p = .008) for early fetal demise. Conclusions: Increased platelet counts in the first trimester may be a predictor for the risk of early fetal demise.
