Identification and quantification of 10 indole/indazole carboxamide synthetic cannabinoids in 36 herbal blends by gas chromatography-mass spectrometry and nuclear magnetic resonance spectroscopy.

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Abstrakt

Tytuł:: Identification and quantification of 10 indole/indazole carboxamide synthetic cannabinoids in 36 herbal blends by gas chromatography-mass spectrometry and nuclear magnetic resonance spectroscopy.
Autorzy:: Liu CM; Key Laboratory of Drug Monitoring and Control, Drug Intelligence and Forensic Center, Ministry of Public Security, P.R.C, Beijing, China.
Jia W; Key Laboratory of Drug Monitoring and Control, Drug Intelligence and Forensic Center, Ministry of Public Security, P.R.C, Beijing, China.
Meng X; Key Laboratory of Drug Monitoring and Control, Drug Intelligence and Forensic Center, Ministry of Public Security, P.R.C, Beijing, China.
Hua ZD; Key Laboratory of Drug Monitoring and Control, Drug Intelligence and Forensic Center, Ministry of Public Security, P.R.C, Beijing, China.
Źródło:: Journal of forensic sciences [J Forensic Sci] 2021 Nov; Vol. 66 (6), pp. 2156-2166. Date of Electronic Publication: 2021 Aug 25.
Typ publikacji:: Journal Article
Język:: English
Imprint Name(s):: Publication: 2006- : Malden, MA : Blackwell Pub.
Original Publication: [Chicago, Ill.] : Callaghan and Co., 1956-
MeSH Terms:: Cannabinoids/*chemistry
Indazoles/*analysis
Indoles/*analysis
Plant Preparations/*chemistry
Synthetic Drugs/*chemistry
Forensic Toxicology/methods ; Gas Chromatography-Mass Spectrometry ; Humans ; Magnetic Resonance Spectroscopy
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Grant Information:: 2016YFC0800903 the National Key Research and Development Program of China
Contributed Indexing:: Keywords: gas chromatography-mass spectrometry; herbal blend; new psychoactive substance; nuclear magnetic resonance spectroscopy; qualitative analysis; quantitative analysis; synthetic cannabinoid
Substance Nomenclature:: 0 (Cannabinoids)
0 (Indazoles)
0 (Indoles)
0 (Plant Preparations)
0 (Synthetic Drugs)
Entry Date(s):: Date Created: 20210825 Date Completed: 20211118 Latest Revision: 20211118
Update Code:: 20240104
DOI:: 10.1111/1556-4029.14873
PMID:: 34431514
: Czasopismo naukowe

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Herbal blends containing synthetic cannabinoids have become popular alternatives to marijuana. The number of synthetic cannabinoids and speed of their emergence enable this group of compounds particularly challenging in terms of detection, monitoring, and responding. In this work, both gas chromatography-mass spectrometry (GC-MS) and nuclear magnetic resonance spectroscopy (NMR) methods were developed for the identification and quantification of synthetic cannabinoids in herbal blends. Ten types of indole/indazole carboxamide synthetic cannabinoids, which showed different types of substitutions connected to nitrogen of the indole/indazole carboxamide, were detected in 36 herbal blends. The GC-MS fragmentation routes of indole/indazole carboxamide synthetic cannabinoids were discussed in detail for structure identification purpose. The concentration range of synthetic cannabinoid in 36 herbal blends was 1.9-50.6 mg/g using GC-MS method, while 1.5-49.0 mg/g by NMR method. Nicotine in herbal blends was quantified by NMR method without using reference material, and showed a variation of 5.3-44.7 mg/g. For quantitative analysis, NMR method showed great advantage in the absence of reference material, while GC-MS method showed great merit for multiple-compound analysis when reference material was available. Therefore, for the quantitative analysis of new emerged synthetic cannabinoid in herbal blends, different methods could be chosen by considering whether reference material is available, as well as the number and types of synthetic cannabinoids detected in a single sample.
(© 2021 American Academy of Forensic Sciences.)

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