Impact of lymphadenectomy and lymphoedema on health-related quality of life 1 year after surgery for endometrial cancer. A prospective longitudinal multicentre study.

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Abstrakt

Tytuł:: Impact of lymphadenectomy and lymphoedema on health-related quality of life 1 year after surgery for endometrial cancer. A prospective longitudinal multicentre study.
Autorzy:: Wedin M; Department of Obstetrics and Gynaecology in Linköping, Department of Biomedical and Clinical Science, Linköping University, Linköping, Sweden.
Stålberg K; Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden.
Marcickiewicz J; Department of Obstetrics and Gynaecology, Varberg Hospital, Varberg, Sweden.
Ahlner E; Department of Oncology, Department of Biomedical and Clinical Science, Linköping University, Linköping, Sweden.
Åkesson Å; Department of Obstetrics and Gynaecology, Sahlgrenska University Hospital, Institute of Clinical Sciences, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.
Lindahl G; Department of Oncology, Department of Biomedical and Clinical Science, Linköping University, Linköping, Sweden.
Wodlin NB; Department of Obstetrics and Gynaecology in Linköping, Department of Biomedical and Clinical Science, Linköping University, Linköping, Sweden.
Kjølhede P; Department of Obstetrics and Gynaecology in Linköping, Department of Biomedical and Clinical Science, Linköping University, Linköping, Sweden.
Corporate Authors:: LASEC study group
Źródło:: BJOG : an international journal of obstetrics and gynaecology [BJOG] 2022 Feb; Vol. 129 (3), pp. 450-460. Date of Electronic Publication: 2021 Sep 07.
Typ publikacji:: Journal Article; Multicenter Study
Język:: English
Imprint Name(s):: Publication: : Oxford : Wiley-Blackwell
Original Publication: Oxford [England] : Blackwell Science, [2000]-
MeSH Terms:: Lymph Node Excision*
Quality of Life*
Endometrial Neoplasms/*surgery
Lymphedema/*epidemiology
Postoperative Complications/*epidemiology
Aged ; Cost of Illness ; Female ; Humans ; Longitudinal Studies ; Lymphedema/etiology ; Middle Aged ; Postoperative Complications/etiology ; Postoperative Period ; Prospective Studies ; Surveys and Questionnaires ; Sweden ; Treatment Outcome
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Grant Information:: LUL-349271 Uppsala-Örebro Regional Research Council; CAN2013/620 The Swedish Cancer Society (Cancerfonden); FORSS-308611 The Medical Research Council of Southeast Sweden; FORSS-391311 The Medical Research Council of Southeast Sweden; FORSS-662141 The Medical Research Council of Southeast Sweden; FORSS-858611 The Medical Research Council of Southeast Sweden; Scientific Council of the Region Halland; County Council of Östergötland; Linköping University
Contributed Indexing:: Keywords: Endometrial cancer; health-related quality-of-life; lower limb; lymphadenectomy; lymphoedema
Entry Date(s):: Date Created: 20210826 Date Completed: 20220124 Latest Revision: 20220430
Update Code:: 20240104
DOI:: 10.1111/1471-0528.16870
PMID:: 34437763
: Czasopismo naukowe

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Objective: To assess the impact of lymphadenectomy and lymphoedema of the lower limbs (LLL) on health-related quality of life (HRQoL) 1 year after surgery for endometrial cancer (EC).
Design: Prospective longitudinal cohort multicentre study.
Setting: Departments of obstetrics and gynaecology at four university hospitals, six central hospitals and four county hospitals in Sweden.
Population: Two-hundred-and-thirty-five women with early stage EC were included; 116 with high-risk EC underwent surgery including lymphadenectomy (+LA), and 119 with low-risk EC had surgery without lymphadenectomy (-LA).
Methods: The generic SF-36 and EQ-5D-3L and the lymphoedema-specific LYMQOL questionnaire were used to assess HRQoL. LLL was assessed by systematic circumferential measurements of the legs enabling volume estimation, clinical evaluation and patient-reported perception of leg swelling. All assessments were carried out on four occasions; preoperatively, and 4-6 weeks, 6 months and 1 year postoperatively.
Main Outcome Measure: HRQoL scores.
Results: No significant differences were seen in HRQoL between the +LA and -LA groups 1 year postoperatively. Irrespective of method of determining LLL, women with LLL were significantly more affected in the LYMQOL domains Function, Appearance/body image and Physical symptoms, but not in the domain Emotion/mood, than women without LLL. No such differences were seen in the generic HRQoL or in the LYMQOL global score between the groups with and without LLL.
Conclusions: Lymphadenectomy did not seem to affect generic HRQoL adversely. Irrespective of the method of measuring, LLL affected the lymphoedema-specific HRQoL negatively, mainly in physical domains, but had no impact on the generic HRQoL.
Tweetable Abstract: Lymphoedema has impact on lymphoedema-specific, but not on generic, HRQoL, 1 year after surgery for EC.
(© 2021 The Authors. BJOG: An International Journal of Obstetrics and Gynaecology published by John Wiley & Sons Ltd.)

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