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Tytuł:
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Barotaxis: How cells live and move under pressure.
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Autorzy:
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Lennon-Duménil AM; Institut Curie, PSL Research University, INSERM U932, F-75005 Paris, France.
Moreau HD; Institut Curie, PSL Research University, INSERM U932, F-75005 Paris, France. Electronic address: .
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Źródło:
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Current opinion in cell biology [Curr Opin Cell Biol] 2021 Oct; Vol. 72, pp. 131-136. Date of Electronic Publication: 2021 Aug 23.
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Typ publikacji:
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Journal Article; Research Support, Non-U.S. Gov't; Review
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Język:
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English
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Imprint Name(s):
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Publication: London : Elsevier
Original Publication: Philadelphia, PA, USA : Current Science, c1988-
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MeSH Terms:
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Chemokines*
Cell Movement
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Substance Nomenclature:
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0 (Chemokines)
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Entry Date(s):
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Date Created: 20210826 Date Completed: 20211125 Latest Revision: 20211125
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Update Code:
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20240104
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DOI:
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10.1016/j.ceb.2021.07.006
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PMID:
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34438279
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Cell migration is an essential process that controls many physiological functions ranging from development to immunity. In vivo, cells are guided by a combination of physical and chemical cues. Chemokines have been the center of attention for years, but the role of physical properties of tissues has been under-investigated, despite the fact that these properties can be drastically modified in pathology. Here, we discuss the role of one important tissue physical property, hydraulic resistance, in cell guidance, a phenomenon referred to as barotaxis, and describe the underlying physical principles and molecular mechanisms. Finally, we speculate on the putative role of barotaxis in physiological processes involving immune and cancer cells.
Competing Interests: Conflict of interest statement None declared.
(Copyright © 2021 Elsevier Ltd. All rights reserved.)
