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Tytuł pozycji:

Lipoic Acid-Modified Oligoethyleneimine-Mediated miR-34a Delivery to Achieve the Anti-Tumor Efficacy.

Tytuł:
Lipoic Acid-Modified Oligoethyleneimine-Mediated miR-34a Delivery to Achieve the Anti-Tumor Efficacy.
Autorzy:
Huang Y; Key Laboratory for Molecular Enzymology and Engineering of Ministry of Education, School of Life Sciences, Jilin University, Changchun 130012, China.
Wang L; Key Laboratory for Molecular Enzymology and Engineering of Ministry of Education, School of Life Sciences, Jilin University, Changchun 130012, China.
Chen Y; Key Laboratory for Molecular Enzymology and Engineering of Ministry of Education, School of Life Sciences, Jilin University, Changchun 130012, China.
Han H; Key Laboratory for Molecular Enzymology and Engineering of Ministry of Education, School of Life Sciences, Jilin University, Changchun 130012, China.
Li Q; Key Laboratory for Molecular Enzymology and Engineering of Ministry of Education, School of Life Sciences, Jilin University, Changchun 130012, China.
Źródło:
Molecules (Basel, Switzerland) [Molecules] 2021 Aug 10; Vol. 26 (16). Date of Electronic Publication: 2021 Aug 10.
Typ publikacji:
Journal Article
Język:
English
Imprint Name(s):
Original Publication: Basel, Switzerland : MDPI, c1995-
MeSH Terms:
Transfection*
Antineoplastic Agents/*pharmacology
MicroRNAs/*metabolism
Polyethyleneimine/*chemistry
Thioctic Acid/*chemistry
Apoptosis/drug effects ; Cell Cycle Checkpoints/drug effects ; Cell Movement/drug effects ; Cell Proliferation/drug effects ; HeLa Cells ; Humans ; MicroRNAs/genetics ; Nanoparticles/ultrastructure ; Polyethyleneimine/chemical synthesis ; Thioctic Acid/chemical synthesis ; Wound Healing/drug effects
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Grant Information:
32071267, 81872928 and 32000897 National Natural Science Foundation of China; 20190201288JC Science & Technology Department of Jilin Province; 2021C041-4 Development and Reform Commission of Jilin Province
Contributed Indexing:
Keywords: anti-tumor efficacy; gene therapy; lipoic acid; miR-34a; oligoethyleneimine
Substance Nomenclature:
0 (Antineoplastic Agents)
0 (MIRN34 microRNA, human)
0 (MicroRNAs)
73Y7P0K73Y (Thioctic Acid)
9002-98-6 (Polyethyleneimine)
Entry Date(s):
Date Created: 20210827 Date Completed: 20210915 Latest Revision: 20210915
Update Code:
20240104
PubMed Central ID:
PMC8400101
DOI:
10.3390/molecules26164827
PMID:
34443415
Czasopismo naukowe
MiR-34a, an important tumor suppressor, has been demonstrated to possess great potential in tumor gene therapy. To achieve the upregulation of miR-34a expression level, an oligoethyleneimine (OEI) derivative was constructed and employed as the carrier through the modification with lipoic acid (LA), namely LA-OEI. In contrast to OEI, the derivative LA-OEI exhibited superior transfection efficiency measured by confocal laser scanning microscopy and flow cytometry, owing to rapid cargo release in the disulfide bond-based reduction sensitive pattern. The anti-proliferation and anti-migration effects were tested after the miR-34a transfection to evaluate the anti-tumor response, using human cervical carcinoma cell line HeLa as a model. The delivery of LA-OEI/miR-34a nanoparticles could achieve obvious anti-proliferative effect caused by the induction of cell apoptosis and cell cycle arrest at G1 phase. In addition, it could inhibit the migration of tumor cells via the downregulation of MMP-9 and Notch-1 level. Overall, the LA-OEI-mediated miR-34a delivery was potential to be used as an effective way in the tumor gene therapy.

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