-
Tytuł:
-
Atrial fibrillation before heart transplantation is a risk factor for post-transplant atrial fibrillation and mortality.
-
Autorzy:
-
Darche FF; Department of Cardiology, Angiology and Pneumology, Heidelberg University Hospital, Im Neuenheimer Feld 410, Heidelberg, 69120, Germany.; Heidelberg Center for Heart Rhythm Disorders (HCR), Heidelberg University Hospital, Heidelberg, Germany.; German Center for Cardiovascular Research (DZHK), Partner Site Heidelberg/Mannheim, Heidelberg, Germany.
Helmschrott M; Department of Cardiology, Angiology and Pneumology, Heidelberg University Hospital, Im Neuenheimer Feld 410, Heidelberg, 69120, Germany.; German Center for Cardiovascular Research (DZHK), Partner Site Heidelberg/Mannheim, Heidelberg, Germany.
Rahm AK; Department of Cardiology, Angiology and Pneumology, Heidelberg University Hospital, Im Neuenheimer Feld 410, Heidelberg, 69120, Germany.; Heidelberg Center for Heart Rhythm Disorders (HCR), Heidelberg University Hospital, Heidelberg, Germany.; German Center for Cardiovascular Research (DZHK), Partner Site Heidelberg/Mannheim, Heidelberg, Germany.
Thomas D; Department of Cardiology, Angiology and Pneumology, Heidelberg University Hospital, Im Neuenheimer Feld 410, Heidelberg, 69120, Germany.; Heidelberg Center for Heart Rhythm Disorders (HCR), Heidelberg University Hospital, Heidelberg, Germany.; German Center for Cardiovascular Research (DZHK), Partner Site Heidelberg/Mannheim, Heidelberg, Germany.
Schweizer PA; Department of Cardiology, Angiology and Pneumology, Heidelberg University Hospital, Im Neuenheimer Feld 410, Heidelberg, 69120, Germany.; Heidelberg Center for Heart Rhythm Disorders (HCR), Heidelberg University Hospital, Heidelberg, Germany.; German Center for Cardiovascular Research (DZHK), Partner Site Heidelberg/Mannheim, Heidelberg, Germany.
Bruckner T; Institute for Medical Biometry and Informatics, University of Heidelberg, Heidelberg, Germany.
Ehlermann P; Department of Cardiology, Angiology and Pneumology, Heidelberg University Hospital, Im Neuenheimer Feld 410, Heidelberg, 69120, Germany.; German Center for Cardiovascular Research (DZHK), Partner Site Heidelberg/Mannheim, Heidelberg, Germany.
Kreusser MM; Department of Cardiology, Angiology and Pneumology, Heidelberg University Hospital, Im Neuenheimer Feld 410, Heidelberg, 69120, Germany.; German Center for Cardiovascular Research (DZHK), Partner Site Heidelberg/Mannheim, Heidelberg, Germany.
Warnecke G; Department of Cardiac Surgery, Heidelberg University Hospital, Heidelberg, Germany.
Frey N; Department of Cardiology, Angiology and Pneumology, Heidelberg University Hospital, Im Neuenheimer Feld 410, Heidelberg, 69120, Germany.; Heidelberg Center for Heart Rhythm Disorders (HCR), Heidelberg University Hospital, Heidelberg, Germany.; German Center for Cardiovascular Research (DZHK), Partner Site Heidelberg/Mannheim, Heidelberg, Germany.
Rivinius R; Department of Cardiology, Angiology and Pneumology, Heidelberg University Hospital, Im Neuenheimer Feld 410, Heidelberg, 69120, Germany.; Heidelberg Center for Heart Rhythm Disorders (HCR), Heidelberg University Hospital, Heidelberg, Germany.; German Center for Cardiovascular Research (DZHK), Partner Site Heidelberg/Mannheim, Heidelberg, Germany.
-
Źródło:
-
ESC heart failure [ESC Heart Fail] 2021 Oct; Vol. 8 (5), pp. 4265-4277. Date of Electronic Publication: 2021 Aug 28.
-
Typ publikacji:
-
Journal Article; Research Support, Non-U.S. Gov't
-
Język:
-
English
-
Imprint Name(s):
-
Original Publication: [Oxford] : John Wiley & Sons Ltd on behalf of the European Society of Cardiology, [2014]-
-
MeSH Terms:
-
Atrial Fibrillation*/epidemiology
Atrial Fibrillation*/etiology
Heart Transplantation*
Mitral Valve Insufficiency*
Adult ; Heart Atria ; Humans ; Risk Factors
-
References:
-
Ther Clin Risk Manag. 2017 Mar 08;13:287-297. (PMID: 28331331)
ESC Heart Fail. 2020 Feb;7(1):176-187. (PMID: 32197001)
J Card Surg. 2005 Jan-Feb;20(1):102-6. (PMID: 15673422)
Circulation. 1996 Aug 1;94(3):390-7. (PMID: 8759081)
J Cardiovasc Electrophysiol. 2000 Sep;11(9):1043-7. (PMID: 11021475)
J Am Coll Cardiol. 2007 Nov 27;50(22):2156-61. (PMID: 18036454)
J Am Heart Assoc. 2012 Apr;1(2):e001461. (PMID: 23130132)
Am J Cardiol. 2001 Aug 1;88(3):280-4. (PMID: 11472708)
Eur Heart J. 2021 Feb 1;42(5):373-498. (PMID: 32860505)
J Thorac Dis. 2019 Dec;11(12):5440-5452. (PMID: 32030263)
J Heart Lung Transplant. 2005 Nov;24(11):1710-20. (PMID: 16297770)
Arq Bras Cardiol. 2010 Jun;94(6):829-40. (PMID: 20625642)
ESC Heart Fail. 2020 Oct;7(5):2082-2092. (PMID: 32608191)
Int J Cardiol Heart Vasc. 2021 Jan 12;32:100710. (PMID: 33490363)
Circulation. 2016 May 10;133(19):1892-900. (PMID: 27166347)
Int J Cardiol. 2007 Feb 7;115(2):135-43. (PMID: 16764958)
J Cardiovasc Electrophysiol. 2012 Feb;23(2):225-7. (PMID: 21668560)
ESC Heart Fail. 2021 Oct;8(5):4265-4277. (PMID: 34453484)
Naunyn Schmiedebergs Arch Pharmacol. 2017 Jan;390(1):1-14. (PMID: 27900409)
Clin Epidemiol. 2018 Sep 27;10:1359-1369. (PMID: 30310328)
Clin Res Cardiol. 2019 Jun;108(6):651-659. (PMID: 30460479)
HeartRhythm Case Rep. 2019 Oct 07;6(1):11-14. (PMID: 31956494)
J Am Coll Cardiol. 1995 Jun;25(7):1673-80. (PMID: 7759722)
Interact Cardiovasc Thorac Surg. 2012 Apr;14(4):457-62. (PMID: 22217865)
JACC Heart Fail. 2017 Feb;5(2):107-109. (PMID: 28089314)
Can J Cardiol. 2017 Oct;33(10):1336.e5-1336.e8. (PMID: 28941612)
Am J Cardiol. 1998 Aug 15;82(4):444-50. (PMID: 9723631)
Europace. 2004 May;6(3):215-9. (PMID: 15121073)
J Thorac Cardiovasc Surg. 2007 Nov;134(5):1322-31. (PMID: 17976469)
J Heart Transplant. 1990 Jul-Aug;9(4):331-8. (PMID: 2398425)
Ann Thorac Surg. 1991 Nov;52(5):1181-4. (PMID: 1953150)
Int J Cardiol. 2018 Feb 1;252:117-121. (PMID: 29249421)
Circ J. 2010 Sep;74(9):1815-21. (PMID: 20631454)
J Am Coll Cardiol. 2008 Feb 26;51(8):793-801. (PMID: 18294562)
Adv Surg. 1966;2:265-84. (PMID: 5333297)
ESC Heart Fail. 2021 Oct;8(5):3737-3747. (PMID: 34213089)
Am J Cardiol. 1992 Oct 15;70(11):1061-3. (PMID: 1384302)
Thorac Cardiovasc Surg. 1991 Apr;39(2):70-2. (PMID: 1877054)
Ann Thorac Surg. 2008 Jan;85(1):56-8. (PMID: 18154778)
Am J Cardiol. 2010 Sep 1;106(5):737-41. (PMID: 20723655)
J Evid Based Med. 2018 Nov;11(4):261-271. (PMID: 30444058)
Clin Res Cardiol. 2021 Jan;110(1):124-135. (PMID: 32405738)
Drug Des Devel Ther. 2014 Sep 09;8:1307-14. (PMID: 25246772)
J Am Coll Cardiol. 2014 Aug 19;64(7):710-21. (PMID: 25125304)
-
Contributed Indexing:
-
Keywords: Atrial fibrillation; Heart transplantation; Pacemaker; Stroke; Survival
-
Entry Date(s):
-
Date Created: 20210828 Date Completed: 20211029 Latest Revision: 20211029
-
Update Code:
-
20240105
-
PubMed Central ID:
-
PMC8497346
-
DOI:
-
10.1002/ehf2.13552
-
PMID:
-
34453484
-
Aims: Atrial fibrillation (AF) after heart transplantation (HTX) is associated with worse clinical outcomes. The current study aimed to analyse the association between AF before HTX and AF within 30 days after HTX.
Methods and Results: This study included 639 adults who received HTX at Heidelberg Heart Center. Patients were subdivided into four groups depending on the status of AF before and after HTX. Analyses comprised recipient and donor data, medication, echocardiographic features, permanent pacemaker implantation, stroke, and mortality after HTX. Three hundred thirty-two patients (52.0%) had neither AF before nor after HTX, 15 patients (2.3%) had no AF before HTX but showed AF after HTX, 219 patients (34.3%) showed AF before HTX but had no AF after HTX, and 73 patients (11.4%) had AF before and after HTX. Patients with AF before and after HTX had a higher 1 year post-transplant mortality (39.7%) than patients without AF before or after HTX (18.1%, P < 0.01). Secondary outcomes showed a higher percentage of enlarged atria, ventricular dysfunction, mitral regurgitation, 1-year stroke, and 1-year permanent pacemaker implantation in patients with AF before and after HTX. Multivariate analysis revealed a six-fold elevated risk for post-transplant AF in patients with AF before HTX (hazard ratio: 6.59, confidence interval: 3.72-11.65; P < 0.01). Further risk factors for post-transplant AF were higher donor age and prolonged ischaemic time, whereas total orthotopic HTX was associated with a two-fold lower risk for post-transplant AF.
Conclusions: Atrial fibrillation before HTX is a risk factor for post-transplant AF, permanent pacemaker implantation, and mortality after HTX.
(© 2021 The Authors. ESC Heart Failure published by John Wiley & Sons Ltd on behalf of European Society of Cardiology.)