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Tytuł:
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Pathological Roles of Prostaglandin E2-specific E-type Prostanoid Receptors in Hormone-sensitive and Castration-resistant Prostate Cancer.
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Autorzy:
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Miyata Y; Department of Urology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan .
Masato M; Department of Urology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
Mukae Y; Department of Urology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
Nakamura Y; Department of Urology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
Matsuda T; Department of Urology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
Harada J; Department of Urology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
Mitsunari K; Department of Urology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
Matsuo T; Department of Urology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
Ohba K; Department of Urology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
Sakai H; Department of Urology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
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Źródło:
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Anticancer research [Anticancer Res] 2021 Sep; Vol. 41 (9), pp. 4333-4341.
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Typ publikacji:
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Journal Article
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Język:
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English
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Imprint Name(s):
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Publication: Attiki, Greece : International Institute of Anticancer Research
Original Publication: Athens, Greece : Potamitis Press
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MeSH Terms:
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Up-Regulation*
Prostatic Neoplasms, Castration-Resistant/*pathology
Receptors, Prostaglandin E, EP4 Subtype/*metabolism
Vascular Endothelial Growth Factor A/*metabolism
Apoptosis ; Cell Proliferation ; Cell Survival ; Gene Expression Regulation, Neoplastic ; Humans ; Male ; Neoplasm Grading ; Neoplasm Staging ; Prostatic Neoplasms, Castration-Resistant/metabolism
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Contributed Indexing:
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Keywords: E-type prostanoid receptors EPRs); apoptosis; castration-resistant prostate cancer (CRPC); proliferation; vascular endothelial growth factor-A
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Substance Nomenclature:
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0 (PTGER4 protein, human)
0 (Receptors, Prostaglandin E, EP4 Subtype)
0 (VEGFA protein, human)
0 (Vascular Endothelial Growth Factor A)
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Entry Date(s):
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Date Created: 20210903 Date Completed: 20210913 Latest Revision: 20210913
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Update Code:
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20240105
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DOI:
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10.21873/anticanres.15238
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PMID:
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34475053
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Background/aim: Prostaglandin (PG) E 2 mediates malignant aggressiveness by binding to four specific E-type prostanoid receptors (EP1R - 4R). This study aimed to clarify the pathological significance of EPRs in hormone-sensitive prostate cancer (HSPC) and castration-resistant prostate cancer (CRPC).
Materials and Methods: EP1R - 4R expression was examined in 102 HSPC and 27 CRPC specimens. The relationships between their expression and proliferation index (PI), apoptotic index (AI), and vascular endothelial growth factor (VEGF)-A expression were analyzed.
Results: EP4R expression in CRPC was significantly higher compared to that in HSPC, even in advanced disease (T3/4, N1, and/or M1). EP4R expression was significantly correlated with PI, AI, and VEGF-A expression in CRPC. Such significant relationships were not detected between EP1R - 3R and CRPC.
Conclusion: EP4R expression in CRPC was significantly higher than that in HSPC and was associated with cancer cell proliferation, apoptosis, and pro-angiogenetic potential.
(Copyright © 2021 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.)