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Tytuł:
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E-Cadherin and Angiopoietin-2 as Potential Biomarkers for Colorectal Cancer With Peritoneal Carcinomatosis.
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Autorzy:
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Kim HK; Department of Internal Medicine, Chungbuk National University Hospital, Cheongju, Republic of Korea.
Yang Y; Department of Internal Medicine, Chungbuk National University Hospital, Cheongju, Republic of Korea.
Byeon S; Department of Internal Medicine, Chungbuk National University Hospital, Cheongju, Republic of Korea.
Jeong Y; Department of Internal Medicine, Chungbuk National University Hospital, Cheongju, Republic of Korea.
Kwon J; Department of Internal Medicine, Chungbuk National University Hospital, Cheongju, Republic of Korea.
Lee KH; Department of Internal Medicine, Chungbuk National University Hospital, Cheongju, Republic of Korea.; Department of Internal Medicine, Chungbuk National University College of Medicine, Cheongju, Republic of Korea.
Son SM; Department of Pathology, Chungbuk National University Hospital, Cheongju, Republic of Korea.; Department of Pathology, Chungbuk National University College of Medicine, Cheongju, Republic of Korea.
Han HS; Department of Internal Medicine, Chungbuk National University Hospital, Cheongju, Republic of Korea; .; Department of Internal Medicine, Chungbuk National University College of Medicine, Cheongju, Republic of Korea.
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Źródło:
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Anticancer research [Anticancer Res] 2021 Sep; Vol. 41 (9), pp. 4497-4504. Date of Electronic Publication: 2021 Sep 01.
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Typ publikacji:
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Journal Article
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Język:
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English
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Imprint Name(s):
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Publication: Attiki, Greece : International Institute of Anticancer Research
Original Publication: Athens, Greece : Potamitis Press
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MeSH Terms:
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Angiopoietin-2/*metabolism
Antigens, CD/*metabolism
Biomarkers, Tumor/*metabolism
Cadherins/*metabolism
Colorectal Neoplasms/*metabolism
Colorectal Neoplasms/*secondary
Peritoneal Neoplasms/*metabolism
Adult ; Aged ; Aged, 80 and over ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; Male ; Middle Aged ; Prognosis ; Retrospective Studies ; Survival Analysis ; Up-Regulation
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Contributed Indexing:
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Keywords: E-Cadherin; angiopoietin-2; colorectal cancer; peritoneal carcinomatosis
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Substance Nomenclature:
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0 (ANGPT2 protein, human)
0 (Angiopoietin-2)
0 (Antigens, CD)
0 (Biomarkers, Tumor)
0 (CDH1 protein, human)
0 (Cadherins)
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Entry Date(s):
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Date Created: 20210903 Date Completed: 20210910 Latest Revision: 20210910
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Update Code:
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20240105
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DOI:
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10.21873/anticanres.15260
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PMID:
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34475075
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Background/aim: E-Cadherin has been implicated in cell-cell adhesion, and soluble E-cadherin is involved in angiogenesis and resistance to anti-angiogenic therapy in several cancer types. This study aimed to investigate the expression and clinical significance of soluble E-cadherin and other angiogenesis-related factors in plasma and malignant ascites of colorectal cancer (CRC) in patients with peritoneal carcinomatosis (PC).
Materials and Methods: Multiplex enzyme-linked immunosorbent assay was performed on 95 body fluid samples (57 plasma and 38 malignant ascites) from patients with CRC. The status of E-cadherin and angiopoietin-2 (AGNPT2) was retrospectively evaluated by immunohistochemistry in primary CRC and paired metastatic peritoneal tissues or cell blocks of malignant ascites of 30 patients with peritoneal metastases of CRC.
Results: The expression levels of soluble E-cadherin and ANGPT2 in plasma samples were significantly increased in patients with PC compared with those without. E-Cadherin concentration was significantly lower and ANGPT2 concentration was significantly higher in malignant ascites than plasma samples. Expression of E-cadherin was strongly positive, whilst that of ANGPT2 was negative in primary colorectal tissues, metastatic peritoneal tissues, and cell blocks of malignant ascites by immunohistochemistry. High levels of soluble E-cadherin or ANGPT2 in ascites were negatively associated with overall survival in patients with CRC with malignant ascites.
Conclusion: Our findings suggest that soluble E-cadherin and ANGPT2 may be surrogate biomarkers for clinical outcome in patients with PC from CRC.
(Copyright © 2021 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.)
