A hydrogel-based implantable multidrug antitubercular formulation outperforms oral delivery.

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Tytuł:: A hydrogel-based implantable multidrug antitubercular formulation outperforms oral delivery.
Autorzy:: Pal S; Laboratory of Nanotechnology and Chemical Biology, Regional Centre for Biotechnology, NCR Biotech Science Cluster, 3rd Milestone, Faridabad-Gurgaon Expressway, Faridabad-121001, Haryana, India. .
Soni V
Kumar S
Jha SK
Medatwal N
Rana K
Yadav P
Mehta D
Jain D
Sharma P
Kar R
Srivastava A
Patil VS
Dasgupta U
Nandicoori VK
Bajaj A
Źródło:: Nanoscale [Nanoscale] 2021 Aug 21; Vol. 13 (31), pp. 13225-13230. Date of Electronic Publication: 2021 Jul 30.
Typ publikacji:: Journal Article
Język:: English
Imprint Name(s):: Original Publication: Cambridge, UK : RSC Pub.
MeSH Terms:: Antitubercular Agents*/pharmacology
Antitubercular Agents*/therapeutic use
Hydrogels*
Animals ; Ethambutol ; Isoniazid ; Mice ; Pyrazinamide
Substance Nomenclature:: 0 (Antitubercular Agents)
0 (Hydrogels)
2KNI5N06TI (Pyrazinamide)
8G167061QZ (Ethambutol)
V83O1VOZ8L (Isoniazid)
Entry Date(s):: Date Created: 20210903 Date Completed: 20210907 Latest Revision: 20210907
Update Code:: 20240105
DOI:: 10.1039/d0nr08806d
PMID:: 34477730
: Czasopismo naukowe

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We present a non-immunogenic, injectable, low molecular weight, amphiphilic hydrogel-based drug delivery system (TB-Gel) that can entrap a cocktail of four front-line antitubercular drugs, isoniazid, rifampicin, pyrazinamide, and ethambutol. We showed that TB-Gel is more effective than oral delivery of the combination of four drugs in reducing the mycobacterial infection in mice. Results show that half the dose of chemotherapeutic drugs is sufficient to achieve a comparable therapeutic effect to that of oral delivery.

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