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Tytuł:
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Eugenol Alleviates Dextran Sulfate Sodium-Induced Colitis Independent of Intestinal Microbiota in Mice.
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Autorzy:
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Chen S; College of Animal Science and Technology, Hunan Agricultural University, Changsha 410128, China.; Key Laboratory of Agro-Ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha 410125, China.; School of Life Science, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou 310024, China.
Wu X; College of Animal Science and Technology, Hunan Agricultural University, Changsha 410128, China.
Tang S; College of Animal Science and Technology, Hunan Agricultural University, Changsha 410128, China.
Yin J; Key Laboratory of Agro-Ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha 410125, China.
Song Z; College of Animal Science and Technology, Hunan Agricultural University, Changsha 410128, China.
He X; College of Animal Science and Technology, Hunan Agricultural University, Changsha 410128, China.
Yin Y; College of Animal Science and Technology, Hunan Agricultural University, Changsha 410128, China.; Key Laboratory of Agro-Ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha 410125, China.
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Źródło:
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Journal of agricultural and food chemistry [J Agric Food Chem] 2021 Sep 15; Vol. 69 (36), pp. 10506-10514. Date of Electronic Publication: 2021 Sep 03.
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Typ publikacji:
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Journal Article
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Język:
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English
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Imprint Name(s):
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Original Publication: Washington, American Chemical Society.
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MeSH Terms:
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Colitis*/chemically induced
Colitis*/drug therapy
Colitis*/genetics
Gastrointestinal Microbiome*
Animals ; Colon ; Cytokines/genetics ; Dextran Sulfate/toxicity ; Disease Models, Animal ; Eugenol ; Mice ; Mice, Inbred C57BL
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Contributed Indexing:
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Keywords: anti-inflammation; antioxidant; colitis; eugenol; gut microbiota
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Substance Nomenclature:
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0 (Cytokines)
3T8H1794QW (Eugenol)
9042-14-2 (Dextran Sulfate)
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Entry Date(s):
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Date Created: 20210903 Date Completed: 20210916 Latest Revision: 20210916
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Update Code:
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20240105
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DOI:
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10.1021/acs.jafc.1c00917
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PMID:
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34478286
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The present study investigated the effect of eugenol (EUG) on dextran sulfate sodium (DSS)-induced colitis and explored the underlying mechanisms. C57BL/6 mice were intragastrically administered normal saline or EUG (20 mg/kg body weight) for 17 days, and colitis was induced by using 3% DSS from day 7. The results showed that EUG increased the body weight and reduced the disease activity index score and colon pathological scores in DSS-treated mice ( P < 0.05). Further, EUG preserved the proinflammatory cytokines (interleukin (IL)-6, -12, -21, and -23), lowered ( P < 0.05) colonic malondialdehyde (MDA), uncoupling protein 2 (UCP2) expression and p65 phosphorylation, and activated ( P < 0.05) colonic kelch-like ECH-associated protein 1 and nuclear factor (erythroid-derived 2)-like 2 expressions but did not affect the intestinal microbiota in DSS-treated mice. Furthermore, EUG ameliorated colitis in antibiotic-treated mice, while fecal microbiota transplantation from EUG preadministered mice failed to ameliorate colitis. In conclusion, EUG could alleviate colitis by attenuating colonic inflammation and oxidative stress independent of intestinal microbiota.