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Tytuł:
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Attitude changes toward prenatal testing among women with twin pregnancies after the introduction of noninvasive prenatal testing: A single-center study in Japan.
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Autorzy:
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Ogawa M; Clinical Research Institute, National Hospital Organization Kyushu Medical Center, Fukuoka, Japan.; Department of Clinical Genetics and Medicine, Kyushu University Hospital, Fukuoka, Japan.
Hasuo Y; Clinical Research Institute, National Hospital Organization Kyushu Medical Center, Fukuoka, Japan.; Department of Obstetrics and Gynecology, National Hospital Organization Kyushu Medical Center, Fukuoka, Japan.; Genetic Counseling Clinic, National Hospital Organization Kyushu Medical Center, Fukuoka, Japan.
Taura Y; Clinical Research Institute, National Hospital Organization Kyushu Medical Center, Fukuoka, Japan.; Department of Obstetrics and Gynecology, National Hospital Organization Kyushu Medical Center, Fukuoka, Japan.; Genetic Counseling Clinic, National Hospital Organization Kyushu Medical Center, Fukuoka, Japan.
Tsunematsu R; Department of Gynecology, National Hospital Organization Kagoshima Medical Center, Kagoshima, Japan.
Shikada S; Department of Clinical Genetics and Medicine, Kyushu University Hospital, Fukuoka, Japan.
Matsushita Y; Clinical Research Institute, National Hospital Organization Kyushu Medical Center, Fukuoka, Japan.; Genetic Counseling Clinic, National Hospital Organization Kyushu Medical Center, Fukuoka, Japan.; Department of Pediatrics, National Hospital Organization Kyushu Medical Center, Fukuoka, Japan.
Sato K; Clinical Research Institute, National Hospital Organization Kyushu Medical Center, Fukuoka, Japan.; Department of Pediatrics, National Hospital Organization Kyushu Medical Center, Fukuoka, Japan.
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Źródło:
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The journal of obstetrics and gynaecology research [J Obstet Gynaecol Res] 2021 Nov; Vol. 47 (11), pp. 3813-3820. Date of Electronic Publication: 2021 Sep 06.
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Typ publikacji:
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Journal Article
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Język:
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English
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Imprint Name(s):
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Publication: [Melbourne, Vic. : Wiley on behalf of the Japan Society of Obstetrics and Gynecology]
Original Publication: Tokyo : University of Tokyo Press, c1996-
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MeSH Terms:
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Genetic Counseling*
Pregnancy, Twin*
Aneuploidy ; Attitude ; Chorion ; Female ; Genetic Testing ; Humans ; Japan ; Pregnancy ; Prenatal Diagnosis
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References:
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Contributed Indexing:
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Keywords: 2.213 genetic counseling; 2.313 serum screening for aneuploidy and anomalies; 2.317 genetic amniocentesis; 2.512 multiple gestation; 4.125 assisted reproductive technology; clinical
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Entry Date(s):
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Date Created: 20210907 Date Completed: 20211103 Latest Revision: 20220731
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Update Code:
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20240105
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PubMed Central ID:
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PMC9292293
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DOI:
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10.1111/jog.15010
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PMID:
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34490692
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Aim: This study aimed to evaluate changes in prenatal testing among women with twin pregnancies before and after the introduction of noninvasive prenatal testing (NIPT). To date, no consensus on prenatal testing for twin pregnancies has been reached in Japan.
Methods: Women pregnant with twins who requested prenatal testing at Kyushu Medical Center from 2005 to 2018 were included in this study. Genetic counseling was provided to all participants. Their chosen methods of testing were collected and classified as invasive diagnosis (ID), noninvasive screening (NIS), and no test requested (NR). Parity, chorionicity, and methods of conception were assessed as attributes. The study period was divided into three terms according to testing availability in our center.
Results: After NIPT was introduced in our center, the use of ID methods decreased and eventually disappeared while NIS came to the forefront. NR was also the preferred choice of women with twin pregnancies before the introduction of NIPT and decreased but did not disappear after introducing NIPT. Women with twin pregnancies who underwent assisted reproduction initially showed hesitation to undergo testing but showed a strong preference for NIS after the introduction of NIPT. Differences in choice according to parity, chorionicity, and methods of conception were found before the introduction of NIPT but disappeared after introducing NIPT.
Conclusion: Increasing information about NIPT has apparently influenced the attitudes of women with twin pregnancies to prenatal testing in Japan. In particular, those who conceive through assisted reproductive technologies exhibited a strong preference for NIPT.
(© 2021 The Authors. Journal of Obstetrics and Gynaecology Research published by John Wiley & Sons Australia, Ltd on behalf of Japan Society of Obstetrics and Gynecology.)
