The Interaction of Heptakis (2,6-di-O-Methyl)-β-cyclodextrin with Mianserin Hydrochloride and Its Influence on the Drug Toxicity.

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Abstrakt

Tytuł:: The Interaction of Heptakis (2,6-di-O-Methyl)-β-cyclodextrin with Mianserin Hydrochloride and Its Influence on the Drug Toxicity.
Autorzy:: Belica-Pacha S; Unit of Biophysical Chemistry, Department of Physical Chemistry, Faculty of Chemistry, University of Lodz, Pomorska 165, 90-236 Lodz, Poland.
Małecka M; Unit of Biophysical Chemistry, Department of Physical Chemistry, Faculty of Chemistry, University of Lodz, Pomorska 165, 90-236 Lodz, Poland.
Daśko M; Department of Inorganic Chemistry, Faculty of Chemistry, Gdansk University of Technology, Narutowicza 11/12, 80-233 Gdansk, Poland.
Miłowska K; Department of General Biophysics, Faculty of Biology and Environmental Protection, University of Lodz, Pomorska 141/143, 90-236 Lodz, Poland.
Bryszewska M; Department of General Biophysics, Faculty of Biology and Environmental Protection, University of Lodz, Pomorska 141/143, 90-236 Lodz, Poland.
Budryn G; Institute of Food Technology and Analysis, Faculty of Biotechnology and Food Sciences, Lodz University of Technology, Stefanowskiego 4-10, 90-924 Lodz, Poland.
Oracz J; Institute of Food Technology and Analysis, Faculty of Biotechnology and Food Sciences, Lodz University of Technology, Stefanowskiego 4-10, 90-924 Lodz, Poland.
Pałecz B; Unit of Biophysical Chemistry, Department of Physical Chemistry, Faculty of Chemistry, University of Lodz, Pomorska 165, 90-236 Lodz, Poland.
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2021 Aug 30; Vol. 22 (17). Date of Electronic Publication: 2021 Aug 30.
Typ publikacji:: Journal Article
Język:: English
Imprint Name(s):: Original Publication: Basel, Switzerland : MDPI, [2000-
MeSH Terms:: Drug Interactions*
Cell Proliferation/*drug effects
Drug-Related Side Effects and Adverse Reactions/*pathology
Mianserin/*toxicity
beta-Cyclodextrins/*toxicity
Animals ; CHO Cells ; Cricetinae ; Cricetulus ; Drug-Related Side Effects and Adverse Reactions/etiology ; Histamine H1 Antagonists/toxicity ; Mianserin/metabolism ; Molecular Docking Simulation ; beta-Cyclodextrins/metabolism
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Contributed Indexing:: Keywords: circular dichroism; cytotoxicity; heptakis (2,6-di-O-methyl)-β-cyclodextrin; isothermal titration calorimetry; mass spectrometry; mianserin hydrochloride; molecular docking
Substance Nomenclature:: 0 (Histamine H1 Antagonists)
0 (beta-Cyclodextrins)
250PJI13LM (Mianserin)
51166-71-3 (heptakis(2,6-O-dimethyl)beta-cyclodextrin)
Entry Date(s):: Date Created: 20210910 Date Completed: 20211018 Latest Revision: 20211018
Update Code:: 20240105
PubMed Central ID:: PMC8430726
DOI:: 10.3390/ijms22179419
PMID:: 34502332
: Czasopismo naukowe

Pełny tekst

One tetracyclic antidepressant, mianserin hydrochloride (MIA), has quite significant side effects on a patients' health. Cyclodextrins, which are most commonly used to reduce the undesirable features of contained drugs within their hydrophobic interior, also have the potential to alter the toxic behavior of the drug. The present paper contains investigations and the characteristics of interaction mechanisms for MIA and the heptakis (2,6-di-O-methyl)-β-cyclodextrin (DM-β-CD) system, and evaluated the effects of the complexation on MIA cytotoxicity. In order to assess whether there was an interaction between MIA and DM-β-CD molecules, isothermal titration calorimetry (ITC) have been chosen. Electrospray ionization mass spectrometry (ESI-MS) helped to establish the complex stoichiometry, and circular dichroism spectroscopy was used to describe the process of complex formation. In order to make a wider interpretative perspective, the molecular docking results have been performed. The viability of Chinese hamster cells were investigated in the presence of DM-β-CD and its complexes with MIA in order to estimate the cytotoxicity of the drug and the conjugate with the chosen cyclodextrin. The viability of B14 cells treated with MIA+DM-β-CD is lower (the toxicity is higher) than with MIA alone, and no protective effects have been observed for complexes of MIA with DM-β-CD in any ratio.

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