Informacja

Drogi użytkowniku, aplikacja do prawidłowego działania wymaga obsługi JavaScript. Proszę włącz obsługę JavaScript w Twojej przeglądarce.

Tytuł pozycji:

Mga Spn is a negative regulator of capsule and phosphorylcholine biosynthesis and influences the virulence of Streptococcus pneumoniae D39.

Tytuł:
Mga Spn is a negative regulator of capsule and phosphorylcholine biosynthesis and influences the virulence of Streptococcus pneumoniae D39.
Autorzy:
Xiao S; Department of Medicine Laboratory, Children's Hospital of Chongqing Medical University; National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders; and Chongqing Key Laboratory of Pediatrics, Chongqing, People's Republic of China.
Suo W; Department of Medicine Laboratory, Children's Hospital of Chongqing Medical University; National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders; and Chongqing Key Laboratory of Pediatrics, Chongqing, People's Republic of China.
Zhang J; Key Laboratory of Diagnostic Medicine Designated by the Ministry of Education, Chongqing Medical University, Chongqing, People's Republic of China.
Zhang X; Key Laboratory of Diagnostic Medicine Designated by the Ministry of Education, Chongqing Medical University, Chongqing, People's Republic of China.
Yin Y; Key Laboratory of Diagnostic Medicine Designated by the Ministry of Education, Chongqing Medical University, Chongqing, People's Republic of China.
Guo X; Department of Medicine Laboratory, Children's Hospital of Chongqing Medical University; National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders; and Chongqing Key Laboratory of Pediatrics, Chongqing, People's Republic of China.
Zheng Y; Department of Medicine Laboratory, Children's Hospital of Chongqing Medical University; National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders; and Chongqing Key Laboratory of Pediatrics, Chongqing, People's Republic of China.
Źródło:
Virulence [Virulence] 2021 Dec; Vol. 12 (1), pp. 2366-2381.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
Język:
English
Imprint Name(s):
Publication: 2015- : Philadelphia, PA : Taylor & Francis
Original Publication: Austin, Tex. : Landes Bioscience
MeSH Terms:
Phosphorylcholine*/metabolism
Streptococcus pneumoniae*/genetics
Streptococcus pneumoniae*/pathogenicity
Transcription Factors*/metabolism
Virulence*
Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; Gene Expression Regulation, Bacterial ; Virulence Factors/genetics
References:
Infect Immun. 2015 May;83(5):1957-72. (PMID: 25733517)
J Bacteriol. 2001 Sep;183(17):5163-70. (PMID: 11489870)
Mol Microbiol. 2007 Dec;66(5):1056-65. (PMID: 18001346)
Wei Sheng Wu Xue Bao. 2015 Jun 4;55(6):780-7. (PMID: 26563004)
Sci Rep. 2016 Jul 08;6:29255. (PMID: 27386955)
Front Microbiol. 2018 Mar 15;9:482. (PMID: 29599764)
Nature. 1995 Oct 5;377(6548):435-8. (PMID: 7566121)
J Mol Microbiol Biotechnol. 2011 Apr;20(2):96-104. (PMID: 21422763)
Exp Mol Med. 2018 Sep 5;50(9):1-14. (PMID: 30185778)
Mol Microbiol. 2009 Jan;71(2):382-90. (PMID: 19040630)
Trends Microbiol. 2013 Mar;21(3):129-35. (PMID: 23273566)
mBio. 2017 Aug 22;8(4):. (PMID: 28830943)
Nucleic Acids Res. 2018 Nov 2;46(19):9990-10006. (PMID: 30165663)
PLoS One. 2020 Oct 19;15(10):e0240834. (PMID: 33075055)
Annu Rev Microbiol. 2011;65:563-81. (PMID: 21721938)
Mol Med Rep. 2017 Jan;15(1):65-74. (PMID: 27922699)
Res Microbiol. 2000 Jul-Aug;151(6):429-35. (PMID: 10961455)
Front Microbiol. 2017 Mar 07;8:277. (PMID: 28326061)
Infect Immun. 2005 Aug;73(8):4653-67. (PMID: 16040978)
Infect Immun. 2002 Oct;70(10):5454-61. (PMID: 12228270)
Nat Rev Microbiol. 2008 Apr;6(4):288-301. (PMID: 18340341)
J Bacteriol. 2003 Jan;185(1):349-58. (PMID: 12486073)
J Infect Dis. 2004 May 15;189(10):1905-13. (PMID: 15122528)
J Bacteriol. 2003 Oct;185(20):6057-66. (PMID: 14526017)
Infect Immun. 2013 Oct;81(10):3903-11. (PMID: 23918778)
J Bacteriol. 2003 Nov;185(22):6640-7. (PMID: 14594838)
Infect Immun. 2018 Jul 23;86(8):. (PMID: 29866907)
Rev Infect Dis. 1981 Mar-Apr;3(2):289-98. (PMID: 7020046)
Infect Immun. 2014 Feb;82(2):694-705. (PMID: 24478084)
Front Microbiol. 2015 Jan 15;5:772. (PMID: 25642214)
Microb Drug Resist. 2012 Jun;18(3):344-58. (PMID: 22432701)
FEMS Microbiol Rev. 2009 May;33(3):572-86. (PMID: 19396958)
Nature. 2015 Aug 13;524(7564):230-3. (PMID: 26168398)
FEMS Microbiol Rev. 2017 Nov 1;41(6):854-879. (PMID: 29029129)
Mol Microbiol. 1999 Mar;31(5):1477-88. (PMID: 10200966)
J Biol Chem. 2006 Sep 1;281(35):25097-109. (PMID: 16787930)
Mol Microbiol. 2016 Jun;100(6):972-88. (PMID: 26919406)
J Bacteriol. 2012 Oct;194(19):5237-44. (PMID: 22821977)
Appl Environ Microbiol. 2001 Nov;67(11):5190-6. (PMID: 11679344)
J Bacteriol. 2014 Sep;196(18):3324-34. (PMID: 25002545)
J Biol Chem. 2006 Jun 2;281(22):15464-74. (PMID: 16597618)
Infect Immun. 2010 Mar;78(3):1276-83. (PMID: 20038538)
Biol Res. 2006;39(1):87-93. (PMID: 16629168)
PLoS Genet. 2015 Sep 17;11(9):e1005518. (PMID: 26378458)
Development. 2020 Aug 14;147(15):. (PMID: 32816903)
J Bacteriol. 2007 Jan;189(1):38-51. (PMID: 17041037)
Front Immunol. 2020 Jan 21;10:3102. (PMID: 32038632)
J Bacteriol. 2012 Sep;194(18):4904-19. (PMID: 22773785)
J Bacteriol. 2004 Feb;186(3):595-600. (PMID: 14729683)
Genes (Basel). 2019 May 22;10(5):. (PMID: 31121970)
Microb Pathog. 1997 Jun;22(6):321-9. (PMID: 9188087)
J Bacteriol. 2012 Aug;194(16):4197-207. (PMID: 22661692)
J Clin Microbiol. 1998 Aug;36(8):2346-8. (PMID: 9666020)
Mol Microbiol. 2007 Oct;66(1):110-26. (PMID: 17725562)
J Bacteriol. 2010 May;192(9):2346-58. (PMID: 20190050)
J Bacteriol. 2005 Nov;187(21):7425-33. (PMID: 16237026)
Contributed Indexing:
Keywords: MgaSpn; Streptococcus pneumoniae; capsule; gene regulation; phosphorylcholine
Molecular Sequence:
figshare 10.6084/m9.figshare.14223077.v1
Substance Nomenclature:
0 (Bacterial Proteins)
0 (Transcription Factors)
0 (Virulence Factors)
107-73-3 (Phosphorylcholine)
Entry Date(s):
Date Created: 20210910 Date Completed: 20220125 Latest Revision: 20220125
Update Code:
20240105
PubMed Central ID:
PMC8437459
DOI:
10.1080/21505594.2021.1972539
PMID:
34506260
Czasopismo naukowe
Global transcriptional regulators are prevalent in gram-positive pathogens. The transcriptional regulators of the Mga/AtxA family regulate target gene expression by directly binding to the promoter regions, that results in the coordinated expression of virulence factors. The spd_1587 gene of Streptococcus pneumoniae strain D39 encodes Mga Spn , which shares sequence similarity with global transcriptional regulators of the Mga/AtxA family. In this study, we demonstrated that Mga Spn regulates the biosynthesis of the capsule and phosphorylcholine, which play key roles in disease severity in S. pneumoniae infections. Mga Spn directly binds to the cps and lic1 promoters and affects the biosynthesis of the capsule and phosphorylcholine. Mga Spn binds to two specific sites on the promoter of cps , one of which contains the -35 box of the promoter, with high affinity. Consistently, low-molecular-weight capsule components were observed in the mgaSpn- null mutant strain. Moreover, we found that phosphorylcholine content was notably increased in the unencapsulated mgaSpn mutant strain. The mgaSpn null mutant caused more severe systemic disease than the parental strain D39. These findings indicate that the pneumococcal Mga Spn protein can inhibit capsule and phosphorylcholine production, thereby affecting the virulence of S. pneumoniae.

Ta witryna wykorzystuje pliki cookies do przechowywania informacji na Twoim komputerze. Pliki cookies stosujemy w celu świadczenia usług na najwyższym poziomie, w tym w sposób dostosowany do indywidualnych potrzeb. Korzystanie z witryny bez zmiany ustawień dotyczących cookies oznacza, że będą one zamieszczane w Twoim komputerze. W każdym momencie możesz dokonać zmiany ustawień dotyczących cookies