Diagnosis, management, and neurodevelopmental outcomes of fetal hydrocephalus: an observational prospective study.

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Tytuł:: Diagnosis, management, and neurodevelopmental outcomes of fetal hydrocephalus: an observational prospective study.
Autorzy:: Wang R; Department of Obstetrics & Gynecology, The Second XiangYa Hospital of Central South University, Central South University, Changsha, Hunan, China.
Ding Y; Department of Obstetrics & Gynecology, The Second XiangYa Hospital of Central South University, Changsha, Hunan, China.
Yang M; Department of Obstetrics & Gynecology, The Second XiangYa Hospital of Central South University, Changsha, Hunan, China. yangmengyuan_.
Lai W; Department of Obstetrics & Gynecology, The Second XiangYa Hospital of Central South University, Changsha, Hunan, China.
Źródło:: Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery [Childs Nerv Syst] 2021 Dec; Vol. 37 (12), pp. 3777-3784. Date of Electronic Publication: 2021 Sep 12.
Typ publikacji:: Journal Article; Observational Study
Język:: English
Imprint Name(s):: Original Publication: Berlin : Springer International, c1985-
MeSH Terms:: Hydrocephalus*/diagnostic imaging
Hydrocephalus*/therapy
Ultrasonography, Prenatal*
Child ; Female ; Fetus ; Humans ; Pregnancy ; Prenatal Diagnosis ; Prospective Studies
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Contributed Indexing:: Keywords: Anti-infection; Fetal hydrocephalus; Intrauterine infection; Neurodevelopment
Entry Date(s):: Date Created: 20210912 Date Completed: 20220110 Latest Revision: 20220110
Update Code:: 20240105
DOI:: 10.1007/s00381-021-05213-9
PMID:: 34510257
: Czasopismo naukowe

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The etiology of fetal hydrocephalus is complex, and the outcome of fetal neurodevelopment after birth is also different. The purpose of this study is to conduct anti-infection of hydrocephalus fetuses with non-specific infection, and observe their neurodevelopment after birth, so as to provide clinical basis for further guidance and management of fetal hydrocephalus. Eighteen single pregnant women with fetal hydrocephalus confirmed by intrapartum ultrasonography in the Second Xiangya Hospital between July 1, 2019, and December 1, 2020, were included. Pelvis MRI, NITP, amniotic fluid/umbilical cord blood puncture, infection index, TORCH, and other examinations were completed during pregnancy. If the patient's infection index is elevated, the second-generation cephalosporin will be used for anti-infection therapy, and the development of fetal hydrocephalus, growth, and neurodevelopment after birth will be observed. Fetal hydrocephalus subsided in 3 cases (25%, 95% CI [0%, 53.7%]) remained stable in 6 cases (50%, 95% CI [16.8%, 83.2%]), progressed in 2 cases (16.7%, 95% CI [0%, 41.4%]), and terminated pregnancy in 1 case (8.7% [0%, 26.7%]). Of the 6 untreated patients, pregnancy was terminated in 3 (50%), hydrocephalus remained stable in 2 (33.3%), and spontaneous resolution in 1 case (16.7%). Fourteen patients delivered successfully, including 11 children with no obvious abnormalities in growth and development, 1 with mild growth retardation and 2 with moderate growth retardation. Anti-infective therapy in the case of non-specific infection or maternal infection can partially prevent the progression of hydrocephalus.
(© 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)

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