Informacja

Drogi użytkowniku, aplikacja do prawidłowego działania wymaga obsługi JavaScript. Proszę włącz obsługę JavaScript w Twojej przeglądarce.

Tytuł pozycji:

OPTN is a host intrinsic restriction factor against neuroinvasive HSV-1 infection.

Tytuł:
OPTN is a host intrinsic restriction factor against neuroinvasive HSV-1 infection.
Autorzy:
Ames J; Department of Microbiology and Immunology, University of Illinois at Chicago, College of Medicine, Chicago, IL, USA.; Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, College of Medicine, Chicago, IL, USA.
Yadavalli T; Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, College of Medicine, Chicago, IL, USA.
Suryawanshi R; Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, College of Medicine, Chicago, IL, USA.
Hopkins J; Department of Microbiology and Immunology, University of Illinois at Chicago, College of Medicine, Chicago, IL, USA.; Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, College of Medicine, Chicago, IL, USA.
Agelidis A; Department of Microbiology and Immunology, University of Illinois at Chicago, College of Medicine, Chicago, IL, USA.; Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, College of Medicine, Chicago, IL, USA.
Patil C; Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, College of Medicine, Chicago, IL, USA.
Fredericks B; Department of Pathology, University of Illinois at Chicago, College of Medicine, Chicago, IL, USA.
Tseng H; Duke Eye Center and Department of Ophthalmology, Duke University Medical Center, Durham, NC, USA.
Valyi-Nagy T; Department of Pathology, University of Illinois at Chicago, College of Medicine, Chicago, IL, USA.
Shukla D; Department of Microbiology and Immunology, University of Illinois at Chicago, College of Medicine, Chicago, IL, USA. .; Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, College of Medicine, Chicago, IL, USA. .
Źródło:
Nature communications [Nat Commun] 2021 Sep 13; Vol. 12 (1), pp. 5401. Date of Electronic Publication: 2021 Sep 13.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Język:
English
Imprint Name(s):
Original Publication: [London] : Nature Pub. Group
MeSH Terms:
Cell Cycle Proteins/*genetics
Central Nervous System/*metabolism
Herpes Simplex/*genetics
Membrane Transport Proteins/*genetics
Animals ; Autophagy/genetics ; Cell Cycle Proteins/metabolism ; Cells, Cultured ; Central Nervous System/virology ; Chlorocebus aethiops ; HeLa Cells ; Herpes Simplex/metabolism ; Herpes Simplex/virology ; Herpesvirus 1, Human/physiology ; Humans ; Membrane Transport Proteins/metabolism ; Mice, Inbred C57BL ; Mice, Knockout ; Necroptosis/genetics ; Neurons/metabolism ; Neurons/virology ; Neuroprotective Agents/metabolism ; RNA Interference ; Vero Cells ; Virus Replication/genetics ; Mice
References:
Neuron. 2018 Jul 11;99(1):64-82.e7. (PMID: 29937276)
Biochem J. 2017 Mar 15;474(7):1163-1174. (PMID: 28159912)
Neurosci Bull. 2017 Jun;33(3):354-356. (PMID: 28271436)
J Immunol. 2004 Jan 1;172(1):392-7. (PMID: 14688347)
Cell Host Microbe. 2012 Sep 13;12(3):334-45. (PMID: 22980330)
Proc Natl Acad Sci U S A. 2016 Apr 12;113(15):4039-44. (PMID: 27035970)
Cell Death Differ. 2020 Jan;27(1):71-84. (PMID: 31076632)
J Neurosci. 2011 Jul 20;31(29):10721-31. (PMID: 21775615)
Mech Ageing Dev. 2011 May;132(5):240-8. (PMID: 21530571)
Neuron. 2018 Dec 19;100(6):1527-1532. (PMID: 30571943)
Vox Sang. 1998;75(3):193-7. (PMID: 9852406)
Nat Protoc. 2013 Dec;8(12):2531-7. (PMID: 24263092)
J Virol. 1988 Aug;62(8):2596-604. (PMID: 2839688)
Science. 2011 Jul 8;333(6039):228-33. (PMID: 21617041)
Genes Dev. 1988 Jun;2(6):718-29. (PMID: 2843425)
PLoS Pathog. 2016 Sep 08;12(9):e1005877. (PMID: 27607440)
Proc Natl Acad Sci U S A. 2019 Aug 13;116(33):16497-16506. (PMID: 31346084)
PLoS Pathog. 2010 Feb 19;6(2):e1000778. (PMID: 20174559)
Trends Cell Biol. 2017 Jul;27(7):491-504. (PMID: 28169082)
Neuropathology. 2011 Dec;31(6):569-74. (PMID: 21284751)
PLoS Pathog. 2009 Mar;5(3):e1000352. (PMID: 19325890)
Cornea. 2001 Jan;20(1):1-13. (PMID: 11188989)
J Virol. 2019 Oct 15;93(21):. (PMID: 31375597)
Cancer Cell. 2014 Jul 14;26(1):106-20. (PMID: 25026213)
Science. 2002 Feb 8;295(5557):1077-9. (PMID: 11834836)
Nature. 2010 May 13;465(7295):223-6. (PMID: 20428114)
PLoS Pathog. 2015 Jul 08;11(7):e1005028. (PMID: 26153886)
PLoS One. 2009;4(4):e5114. (PMID: 19340308)
J Virol. 2009 Dec;83(23):12164-71. (PMID: 19759141)
Nature. 2015 Aug 20;524(7565):309-314. (PMID: 26266977)
Hum Mol Genet. 2015 Jul 1;24(13):3830-46. (PMID: 25859013)
Cell Host Microbe. 2010 Feb 18;7(2):115-27. (PMID: 20159618)
Science. 2016 Aug 5;353(6299):603-8. (PMID: 27493188)
Toxins (Basel). 2017 Sep 05;9(9):. (PMID: 28872615)
Nat Commun. 2016 Sep 13;7:12708. (PMID: 27620379)
J Virol. 2019 Mar 5;93(6):. (PMID: 30602607)
Grant Information:
P30 EY001792 United States EY NEI NIH HHS; K08 EY021520 United States EY NEI NIH HHS; R01 AI139768 United States AI NIAID NIH HHS; R01 EY029426 United States EY NEI NIH HHS; R01 EY024710 United States EY NEI NIH HHS
Substance Nomenclature:
0 (Cell Cycle Proteins)
0 (Membrane Transport Proteins)
0 (Neuroprotective Agents)
0 (Optn protein, mouse)
Entry Date(s):
Date Created: 20210914 Date Completed: 20211018 Latest Revision: 20240226
Update Code:
20240226
PubMed Central ID:
PMC8437952
DOI:
10.1038/s41467-021-25642-z
PMID:
34518549
Czasopismo naukowe
Fast-replicating neurotropic herpesviruses exemplified by herpes simplex virus-1 (HSV-1) naturally infect the central nervous system (CNS). However, most individuals intrinsically suppress the virus during a primary infection and preclude it from significantly damaging the CNS. Optineurin (OPTN) is a conserved autophagy receptor with little understanding of its role in neurotropic viral infections. We show that OPTN selectively targets HSV-1 tegument protein, VP16, and the fusion glycoprotein, gB, to degradation by autophagy. OPTN-deficient mice challenged with HSV-1 show significant cognitive decline and susceptibility to lethal CNS infection. OPTN deficiency unveils severe consequences for recruitment of adaptive immunity and suppression of neuronal necroptosis. Ocular HSV-1 infection is lethal without OPTN and is rescued using a necroptosis inhibitor. These results place OPTN at the crux of neuronal survival from potentially lethal CNS viral infections.
(© 2021. The Author(s).)

Ta witryna wykorzystuje pliki cookies do przechowywania informacji na Twoim komputerze. Pliki cookies stosujemy w celu świadczenia usług na najwyższym poziomie, w tym w sposób dostosowany do indywidualnych potrzeb. Korzystanie z witryny bez zmiany ustawień dotyczących cookies oznacza, że będą one zamieszczane w Twoim komputerze. W każdym momencie możesz dokonać zmiany ustawień dotyczących cookies