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Tytuł pozycji:

Effects of endurance training on the expression of host proteins involved in SARS-CoV-2 cell entry in C57BL/6J mouse.

Tytuł:
Effects of endurance training on the expression of host proteins involved in SARS-CoV-2 cell entry in C57BL/6J mouse.
Autorzy:
Tamura Y; Graduate School of Health and Sport Science, Nippon Sport Science University, Tokyo, Japan.; Research Institute for Sport Science, Nippon Sport Science University, Tokyo, Japan.; Faculty of Sport Science, Nippon Sport Science University, Tokyo, Japan.
Jee E; Graduate School of Health and Sport Science, Nippon Sport Science University, Tokyo, Japan.
Kouzaki K; Research Institute for Sport Science, Nippon Sport Science University, Tokyo, Japan.; Graduate School of Medical and Health Science, Nippon Sport Science University, Tokyo, Japan.; Faculty of Medical Science, Nippon Sport Science University, Tokyo, Japan.
Kotani T; Research Institute for Sport Science, Nippon Sport Science University, Tokyo, Japan.
Nakazato K; Graduate School of Health and Sport Science, Nippon Sport Science University, Tokyo, Japan.; Research Institute for Sport Science, Nippon Sport Science University, Tokyo, Japan.; Graduate School of Medical and Health Science, Nippon Sport Science University, Tokyo, Japan.; Faculty of Medical Science, Nippon Sport Science University, Tokyo, Japan.
Źródło:
Physiological reports [Physiol Rep] 2021 Sep; Vol. 9 (17), pp. e15014.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
Język:
English
Imprint Name(s):
Original Publication: [Malden MA] : published by Wiley Periodicals, Inc. on behalf of the American Physiological Society and The Physiological Society, 2013-
MeSH Terms:
Physical Conditioning, Animal*
Physical Endurance*
Virus Internalization*
COVID-19/*virology
Receptors, Virus/*metabolism
SARS-CoV-2/*pathogenicity
Angiotensin-Converting Enzyme 2/metabolism ; Animals ; COVID-19/enzymology ; Furin/metabolism ; Host-Pathogen Interactions ; Male ; Mice, Inbred C57BL ; Neuropilin-1/metabolism ; Running ; Serine Endopeptidases/metabolism ; Mice
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Grant Information:
Nippon Sport Science University Research Grant
Contributed Indexing:
Keywords: COVID-19; SARS-CoV-2; endurance exercise; endurance training; mouse
Substance Nomenclature:
0 (Furin protein, mouse)
0 (Receptors, Virus)
144713-63-3 (Neuropilin-1)
EC 3.4.17.23 (Ace2 protein, mouse)
EC 3.4.17.23 (Angiotensin-Converting Enzyme 2)
EC 3.4.21.- (Serine Endopeptidases)
EC 3.4.21.- (TMPRSS2 protein, mouse)
EC 3.4.21.75 (Furin)
Entry Date(s):
Date Created: 20210915 Date Completed: 20210922 Latest Revision: 20240226
Update Code:
20240226
PubMed Central ID:
PMC8440939
DOI:
10.14814/phy2.15014
PMID:
34523264
Czasopismo naukowe
The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is threatening people's lives and impacting their health. It is still unclear whether people engaged in physical activity are at an increased risk of SARS-CoV-2 infection and severe forms of COVID-19. In order to provide data to help answer this question, we, therefore, investigated the effects of endurance training on the levels of host proteins involved in SARS-CoV-2 infection in mice. Eight-week-old C57BL/6J mice were subjected to treadmill running (17-25 m/min, 60-90 min, 5 sessions/week, 8 weeks). After the intervention, the levels of angiotensin-converting enzyme 2 (ACE2; host receptor for SARS-CoV-2), transmembrane protease serine 2 (TMPRSS2; host protease priming fusion of SARS-CoV-2 to host cell membranes), FURIN (host protease that promotes binding of SARS-CoV-2 to host receptors), and Neuropilin-1 (host coreceptor for SARS-CoV-2) were measured in 10 organs that SARS-CoV-2 can infect (larynx, trachea, lung, heart, jejunum, ileum, colon, liver, kidney, and testis). Six organs (heart, lung, jejunum, liver, trachea, and ileum) showed changes in the levels of at least one of the proteins. Endurance training increased ACE2 levels in heart (+66.4%), lung (+37.1%), jejunum (+24.7%) and liver (+27.4%), and FURIN in liver (+17.9%) tissue. In contrast, endurance training decreased Neuropilin-1 levels in liver (-39.7%), trachea (-41.2%), and ileum (-39.7%), and TMPRSS2 in lung (-11.3%). Taken together, endurance training altered the levels of host proteins involved in SARS-CoV-2 cell entry in an organ-dependent manner.
(© 2021 The Authors. Physiological Reports published by Wiley Periodicals LLC on behalf of The Physiological Society and the American Physiological Society.)
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