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Tytuł:
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A facile method for high-throughput screening of drug-eluting coatings in droplet microarrays based on ultrasonic spray deposition.
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Autorzy:
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Wang C; MOE Key Laboratory of Macromolecule Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, PR China. .
Xue Y; MOE Key Laboratory of Macromolecule Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, PR China. .
Huang J; MOE Key Laboratory of Macromolecule Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, PR China. .
Ren K; MOE Key Laboratory of Macromolecule Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, PR China. .
Greiner A; Macromolecular Chemistry II, University of Bayreuth, Universitätsstr. 30, 95440 Bayreuth, Germany.
Agarwal S; Macromolecular Chemistry II, University of Bayreuth, Universitätsstr. 30, 95440 Bayreuth, Germany.
Ji J; MOE Key Laboratory of Macromolecule Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, PR China. .
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Źródło:
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Biomaterials science [Biomater Sci] 2021 Oct 12; Vol. 9 (20), pp. 6787-6794. Date of Electronic Publication: 2021 Oct 12.
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Typ publikacji:
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Journal Article
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Język:
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English
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Imprint Name(s):
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Original Publication: Cambridge, UK : Royal Society of Chemistry
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MeSH Terms:
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High-Throughput Screening Assays*
Ultrasonics*
Drug Liberation ; Excipients ; Polymers ; Water
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Substance Nomenclature:
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0 (Excipients)
0 (Polymers)
059QF0KO0R (Water)
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Entry Date(s):
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Date Created: 20210916 Date Completed: 20211014 Latest Revision: 20220531
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Update Code:
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20240105
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DOI:
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10.1039/d1bm01213d
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PMID:
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34528030
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Coating modification such as drug-eluting coating is one of the most important approaches for the functionalization of biomedical devices. However, the throughputs are limited in conventional coating methods and the concept of miniaturization is rarely fulfilled. A droplet microarray (DMA), as a unique high-throughput platform, can avoid cross-contamination and reduce the consumption of materials which is inherently suitable for coating research yet is difficult to apply with coating materials via traditional methods. Here, we bring up a facile method based on ultrasonic spray deposition to integrate coating materials into a DMA. Several common polymer materials were selected to fabricate a DMA, and the obtained DMA showed the ability to anchor water droplets and form specific patterns. Coating arrays with a typical sandwich structure were also prepared for the high-throughput screening of drug-eluting coatings to demonstrate the potential of the platform in coating research. This developed method is efficient and compatible and enriches the choices of materials that can be applied in DMAs.
