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Tytuł:
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[T cell receptor (TCR) repertoire and common analytical tools for high-throughput sequencing].
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Autorzy:
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Zhang M; Immunology Laboratory, Zunyi Medical University, Zunyi 563000, China.
Li J; Immunology Laboratory, Zunyi Medical University, Zunyi 563000, China.
Shi B; Immunology Laboratory, Zunyi Medical University, Zunyi 563000, China.
Yao X; Immunology Laboratory, Zunyi Medical University, Zunyi 563000, China. *Corresponding author, E-mail: .
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Źródło:
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Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology [Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi] 2021 Sep; Vol. 37 (9), pp. 851-857.
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Typ publikacji:
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Journal Article
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Język:
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Chinese
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Imprint Name(s):
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Original Publication: Xiʹan : Xi bao yu fen zi mian yi xue za zhi bian ji bu
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MeSH Terms:
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High-Throughput Nucleotide Sequencing*
Receptors, Antigen, T-Cell*/genetics
Receptors, Antigen, T-Cell, alpha-beta ; T-Lymphocytes
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Substance Nomenclature:
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0 (Receptors, Antigen, T-Cell)
0 (Receptors, Antigen, T-Cell, alpha-beta)
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Entry Date(s):
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Date Created: 20210917 Date Completed: 20210920 Latest Revision: 20210920
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Update Code:
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20240105
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PMID:
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34533132
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T cell receptor (TCR) is an integral part of T cell recognition antigen, and the sum of TCR of all T cells in an individual is called the TCR repertoire. Understanding the composition and characteristics of the TCR repertoire in healthy and pathological state helps us to gain an insight into adaptive immunity. At present, many analysis tools for high-throughput data have been developed, including basic composition analysis and downstream function analysis. The database of antigen-specific T cells established by researchers is fundamental to clinical research. The analysis of the functional characteristics of the TCR repertoire is critical to the understanding of TCR repertoire. However, the existing downstream analysis tools still requires further application and verification. This paper reviewed several commonly used TCR repertoire analysis tools, which hopefully can provide a reference for non-bioinformatics researchers in choosing analysis tools.
