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Tytuł:
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Underweight Is Associated with Poor Prognosis in Heart Failure with Preserved Ejection Fraction.
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Autorzy:
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Matsuhiro Y; Division of Cardiology, Osaka Rosai Hospital.
Nishino M; Division of Cardiology, Osaka Rosai Hospital.
Ukita K; Division of Cardiology, Osaka Rosai Hospital.
Kawamura A; Division of Cardiology, Osaka Rosai Hospital.
Nakamura H; Division of Cardiology, Osaka Rosai Hospital.
Yasumoto K; Division of Cardiology, Osaka Rosai Hospital.
Tsuda M; Division of Cardiology, Osaka Rosai Hospital.
Okamoto N; Division of Cardiology, Osaka Rosai Hospital.
Tanaka A; Division of Cardiology, Osaka Rosai Hospital.
Matsunaga-Lee Y; Division of Cardiology, Osaka Rosai Hospital.
Yano M; Division of Cardiology, Osaka Rosai Hospital.
Egami Y; Division of Cardiology, Osaka Rosai Hospital.
Shutta R; Division of Cardiology, Osaka Rosai Hospital.
Tanouchi J; Division of Cardiology, Osaka Rosai Hospital.
Yamada T; Division of Cardiology, Osaka General Medical Center.
Yasumura Y; Division of Cardiology, Amagasaki Chuo Hospital.
Tamaki S; Division of Cardiology, Osaka General Medical Center.
Hayashi T; Cardiovascular Division, Osaka Police Hospital.
Nakagawa A; Division of Cardiology, Amagasaki Chuo Hospital.
Nakagawa Y; Division of Cardiology, Kawanishi City Hospital.
Sotomi Y; Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine.
Nakatani D; Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine.
Hikoso S; Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine.
Sakata Y; Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine.
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Corporate Authors:
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Osaka CardioVascular Conference (OCVC) -Heart Failure Investigators
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Źródło:
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International heart journal [Int Heart J] 2021 Sep 30; Vol. 62 (5), pp. 1042-1051. Date of Electronic Publication: 2021 Sep 17.
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Typ publikacji:
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Journal Article; Multicenter Study; Observational Study
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Język:
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English
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Imprint Name(s):
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Original Publication: [Tokyo, Japan] : International Heart Journal Association, [2005]-
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MeSH Terms:
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Heart Failure/*complications
Heart Failure/*mortality
Heart Failure/*physiopathology
Stroke Volume/*physiology
Thinness/*complications
Aged ; Aged, 80 and over ; Asian People/ethnology ; Asian People/statistics & numerical data ; Body Mass Index ; Case-Control Studies ; Cause of Death/trends ; Comorbidity ; Female ; Follow-Up Studies ; Frailty/complications ; Heart Failure/epidemiology ; Humans ; Japan/epidemiology ; Male ; Nutritional Status/physiology ; Overweight/complications ; Prevalence ; Prognosis ; Prospective Studies ; Registries ; Thinness/epidemiology
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Contributed Indexing:
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Keywords: Acute decompensated heart failure; Body mass index; Heart failure with preserved ejection fraction; Obesity paradox
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Entry Date(s):
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Date Created: 20210921 Date Completed: 20211011 Latest Revision: 20221207
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Update Code:
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20240105
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DOI:
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10.1536/ihj.21-195
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PMID:
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34544985
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The obesity paradox states higher body mass index (BMI) is associated with better outcomes than normal weight in patients with heart failure with preserved ejection fraction (HFpEF). However, underweight was defined by BMI < 18.5 kg/m 2 , and results have been inconclusive, in part due to small number of participants. The number of underweight patients with HFpEF is higher in Asian than in Western countries. In this study, we aim to determine the prognostic impact of underweight in patients with HFpEF in Asian population.We enrolled 846 consecutive patients from the PURSUIT-HFpEF registry. We then divided them into three groups by BMI, namely, underweight (BMI < 18.5 kg/m 2 ), normal weight (18.5 ≤ BMI < 23), and overweight (23 ≤ BMI). The underweight group consisted of 187 patients (22%). Over a mean follow-up of 407 days, 105 deaths were reported as all-cause mortality. On multivariable Cox analysis, the underweight group was determined to be significantly associated with higher risk of all-cause mortality than the normal and overweight groups (Hazard ratios [HR]: 2.33; 95% confidence intervals [CI]: 1.45-3.75, P < 0.001; HR: 3.54; 95% CI: 1.99-6.29, P < 0.001, respectively), after adjustment for age, sex, vital signs, and comorbidities.Underweight is a useful predictor of poor prognosis in patients with HFpEF in Asian population.