Emergent probability fluxes in confined microbial navigation.

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Abstrakt

Tytuł:: Emergent probability fluxes in confined microbial navigation.
Autorzy:: Cammann J; Interdisciplinary Centre for Mathematical Modelling, Loughborough University, Loughborough LE11 3TU, United Kingdom.; Department of Mathematical Sciences, Loughborough University, Loughborough LE11 3TU, United Kingdom.; Department of Dynamics of Complex Fluids, Max Planck Institute for Dynamics and Self-Organization, 37077 Göttingen, Germany.
Schwarzendahl FJ; Department of Dynamics of Complex Fluids, Max Planck Institute for Dynamics and Self-Organization, 37077 Göttingen, Germany.; Institut für Theoretische Physik II: Weiche Materie, Heinrich-Heine-Universität Düsseldorf, 40225 Düsseldorf, Germany.; Department of Physics, University of California, Merced, CA 95343.
Ostapenko T; Department of Dynamics of Complex Fluids, Max Planck Institute for Dynamics and Self-Organization, 37077 Göttingen, Germany.
Lavrentovich D; Department of Dynamics of Complex Fluids, Max Planck Institute for Dynamics and Self-Organization, 37077 Göttingen, Germany.
Bäumchen O; Department of Dynamics of Complex Fluids, Max Planck Institute for Dynamics and Self-Organization, 37077 Göttingen, Germany.; Experimental Physics V, University of Bayreuth, 95447 Bayreuth, Germany.
Mazza MG; Interdisciplinary Centre for Mathematical Modelling, Loughborough University, Loughborough LE11 3TU, United Kingdom; .; Department of Mathematical Sciences, Loughborough University, Loughborough LE11 3TU, United Kingdom.; Department of Dynamics of Complex Fluids, Max Planck Institute for Dynamics and Self-Organization, 37077 Göttingen, Germany.
Źródło:: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2021 Sep 28; Vol. 118 (39).
Typ publikacji:: Journal Article
Język:: English
Imprint Name(s):: Original Publication: Washington, DC : National Academy of Sciences
MeSH Terms:: Cell Movement*
Hydrodynamics*
Mathematical Concepts*
Chlamydomonas reinhardtii/*cytology
Chlamydomonas reinhardtii/*physiology
Microfluidics/*methods
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Contributed Indexing:: Keywords: active matter; microbial motility; microswimmers; nonequilibrium statistical mechanics; probability fluxes
Entry Date(s):: Date Created: 20210924 Date Completed: 20211007 Latest Revision: 20211026
Update Code:: 20240105
PubMed Central ID:: PMC8488662
DOI:: 10.1073/pnas.2024752118
PMID:: 34556571
: Czasopismo naukowe

When the motion of a motile cell is observed closely, it appears erratic, and yet the combination of nonequilibrium forces and surfaces can produce striking examples of organization in microbial systems. While most of our current understanding is based on bulk systems or idealized geometries, it remains elusive how and at which length scale self-organization emerges in complex geometries. Here, using experiments and analytical and numerical calculations, we study the motion of motile cells under controlled microfluidic conditions and demonstrate that probability flux loops organize active motion, even at the level of a single cell exploring an isolated compartment of nontrivial geometry. By accounting for the interplay of activity and interfacial forces, we find that the boundary's curvature determines the nonequilibrium probability fluxes of the motion. We theoretically predict a universal relation between fluxes and global geometric properties that is directly confirmed by experiments. Our findings open the possibility to decipher the most probable trajectories of motile cells and may enable the design of geometries guiding their time-averaged motion.
Competing Interests: The authors declare no competing interest.
(Copyright © 2021 the Author(s). Published by PNAS.)

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