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Tytuł pozycji:

Glycolytic Reprogramming in Silica-Induced Lung Macrophages and Silicosis Reversed by Ac-SDKP Treatment.

Tytuł:
Glycolytic Reprogramming in Silica-Induced Lung Macrophages and Silicosis Reversed by Ac-SDKP Treatment.
Autorzy:
Mao N; Hebei Key Laboratory for Organ Fibrosis Research, School of Public Health, North China University of Science and Technology, Tangshan 063210, China.
Yang H; Hebei Key Laboratory for Organ Fibrosis Research, School of Public Health, North China University of Science and Technology, Tangshan 063210, China.
Yin J; Hebei Key Laboratory for Organ Fibrosis Research, School of Public Health, North China University of Science and Technology, Tangshan 063210, China.
Li Y; Hebei Key Laboratory for Organ Fibrosis Research, School of Public Health, North China University of Science and Technology, Tangshan 063210, China.
Jin F; Hebei Key Laboratory for Organ Fibrosis Research, School of Public Health, North China University of Science and Technology, Tangshan 063210, China.
Li T; Hebei Key Laboratory for Chronic Diseases, Basic Medical College, North China University of Science and Technology, Tangshan 063210, China.
Yang X; Hebei Key Laboratory for Chronic Diseases, Basic Medical College, North China University of Science and Technology, Tangshan 063210, China.
Sun Y; Hebei Key Laboratory for Chronic Diseases, Basic Medical College, North China University of Science and Technology, Tangshan 063210, China.
Liu H; Hebei Key Laboratory for Organ Fibrosis Research, School of Public Health, North China University of Science and Technology, Tangshan 063210, China.
Xu H; Hebei Key Laboratory for Organ Fibrosis Research, School of Public Health, North China University of Science and Technology, Tangshan 063210, China.
Yang F; Hebei Key Laboratory for Organ Fibrosis Research, School of Public Health, North China University of Science and Technology, Tangshan 063210, China.
Źródło:
International journal of molecular sciences [Int J Mol Sci] 2021 Sep 17; Vol. 22 (18). Date of Electronic Publication: 2021 Sep 17.
Typ publikacji:
Journal Article
Język:
English
Imprint Name(s):
Original Publication: Basel, Switzerland : MDPI, [2000-
MeSH Terms:
Glycolysis*
Lung/*drug effects
Macrophages/*drug effects
Silicon Dioxide/*adverse effects
Silicosis/*therapy
Animals ; Fibroblasts/metabolism ; Inflammation/drug therapy ; Macrophages, Alveolar/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Oligopeptides/pharmacology ; Pulmonary Fibrosis/metabolism ; RNA, Small Interfering/metabolism ; Rats ; Rats, Wistar
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Grant Information:
H2020209052 National Natural Science Foundation of Hebei Province; 81972988 National Natural Science Foundation of China; 192777129D Key Research and Development Projects of Hebei Province; ZD2019077 Science and Technology Research Project of Hebei Education Department
Contributed Indexing:
Keywords: N-acetyl-seryl-aspartyl-lysyl-proline; glycolysis; inflammation; macrophages; silicosis
Substance Nomenclature:
0 (Oligopeptides)
0 (RNA, Small Interfering)
7631-86-9 (Silicon Dioxide)
H041538E9P (goralatide)
Entry Date(s):
Date Created: 20210928 Date Completed: 20211115 Latest Revision: 20211115
Update Code:
20240105
PubMed Central ID:
PMC8465686
DOI:
10.3390/ijms221810063
PMID:
34576239
Czasopismo naukowe
Glycolytic reprogramming is an important metabolic feature in the development of pulmonary fibrosis. However, the specific mechanism of glycolysis in silicosis is still not clear. In this study, silicotic models and silica-induced macrophage were used to elucidate the mechanism of glycolysis induced by silica. Expression levels of the key enzymes in glycolysis and macrophage activation indicators were analyzed by Western blot, qRT-PCR, IHC, and IF analyses, and by using a lactate assay kit. We found that silica promotes the expression of the key glycolysis enzymes HK2, PKM2, LDHA, and macrophage activation factors iNOS, TNF-α, Arg-1, IL-10, and MCP1 in silicotic rats and silica-induced NR8383 macrophages. The enhancement of glycolysis and macrophage activation induced by silica was reduced by Ac-SDKP or siRNA- Ldha treatment. This study suggests that Ac-SDKP treatment can inhibit glycolytic reprogramming in silica-induced lung macrophages and silicosis.

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