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Tytuł pozycji:

A case of intraductal papillary mucinous neoplasm developing in the native pancreas after pancreas transplantation treated by total pancreatectomy.

Tytuł:
A case of intraductal papillary mucinous neoplasm developing in the native pancreas after pancreas transplantation treated by total pancreatectomy.
Autorzy:
Sato H; Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University, 2-2-E2, Yamadaoka, Suita, Osaka, 565-0871, Japan.; Department of Gastroenterological Surgery, Ikeda City Hospital, Ikeda, Japan.
Tomimaru Y; Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University, 2-2-E2, Yamadaoka, Suita, Osaka, 565-0871, Japan.
Akita H; Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University, 2-2-E2, Yamadaoka, Suita, Osaka, 565-0871, Japan.
Kobayashi S; Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University, 2-2-E2, Yamadaoka, Suita, Osaka, 565-0871, Japan. .
Ito T; Osaka Center for Cancer and Cardiovascular Disease Prevention, Osaka, Japan.
Sasaki K; Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University, 2-2-E2, Yamadaoka, Suita, Osaka, 565-0871, Japan.
Iwagami Y; Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University, 2-2-E2, Yamadaoka, Suita, Osaka, 565-0871, Japan.
Yamada D; Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University, 2-2-E2, Yamadaoka, Suita, Osaka, 565-0871, Japan.
Noda T; Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University, 2-2-E2, Yamadaoka, Suita, Osaka, 565-0871, Japan.
Gotoh K; Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University, 2-2-E2, Yamadaoka, Suita, Osaka, 565-0871, Japan.
Takahashi H; Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University, 2-2-E2, Yamadaoka, Suita, Osaka, 565-0871, Japan.
Hama N; Department of Gastroenterological Surgery, Ikeda City Hospital, Ikeda, Japan.
Asaoka T; Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University, 2-2-E2, Yamadaoka, Suita, Osaka, 565-0871, Japan.
Tanemura M; Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University, 2-2-E2, Yamadaoka, Suita, Osaka, 565-0871, Japan.
Doki Y; Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University, 2-2-E2, Yamadaoka, Suita, Osaka, 565-0871, Japan.
Eguchi H; Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University, 2-2-E2, Yamadaoka, Suita, Osaka, 565-0871, Japan.
Źródło:
Clinical journal of gastroenterology [Clin J Gastroenterol] 2021 Dec; Vol. 14 (6), pp. 1766-1771. Date of Electronic Publication: 2021 Sep 29.
Typ publikacji:
Case Reports; Journal Article
Język:
English
Imprint Name(s):
Original Publication: [Tokyo] : Springer Japan
MeSH Terms:
Adenocarcinoma, Mucinous*/etiology
Adenocarcinoma, Mucinous*/surgery
Carcinoma, Pancreatic Ductal*/surgery
Pancreas Transplantation*/adverse effects
Pancreatic Neoplasms*/surgery
Humans ; Male ; Middle Aged ; Neoplasm Recurrence, Local ; Pancreas ; Pancreatectomy ; Retrospective Studies
References:
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Contributed Indexing:
Keywords: Intraductal papillary mucinous neoplasm; Native pancreas; Pancreas transplantation; Total pancreatectomy
Entry Date(s):
Date Created: 20210929 Date Completed: 20211102 Latest Revision: 20211102
Update Code:
20240105
DOI:
10.1007/s12328-021-01517-0
PMID:
34585331
Czasopismo naukowe
Post-transplant patients reportedly have a higher risk of de novo neoplasms. However, intraductal papillary mucinous neoplasm (IPMN) of the native pancreas after pancreas transplantation (PTx) has not been well investigated. The choice of treatment, especially invasive treatment, for de novo neoplasms in transplant patients should consider their impaired immunity. In this context, we present a case of IPMN developing in the native pancreas of a PTx patient. A 53-year-old man underwent a follow-up abdominal computed tomography scan 6 years after a simultaneous pancreas-kidney transplant for type 1 diabetes mellitus with end-stage diabetic nephropathy requiring hemodialysis. The scan revealed IPMN in the pancreas head; an enhancing internal solid component suggested a high risk of malignancy, indicating surgical resection. Partial pancreatectomy or pancreaticoduodenectomy was anatomically indicated, but considering the insulin-secreting ability of the transplanted pancreas and the potential high risk of postoperative pancreatic fistula due to immune impairment after partial pancreatectomy, total pancreatectomy (TP) was performed. The patient is alive with good pancreas graft function, no signs of indigestion for 18 months after TP, and no evidence of IPMN recurrence. This report should help clinicians characterize de novo IPMN in the native pancreas and determine IPMN therapeutic options for transplant patients.
(© 2021. Japanese Society of Gastroenterology.)

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