-
Tytuł:
-
LncRNA HCG11 mediated by METTL14 inhibits the growth of lung adenocarcinoma via IGF2BP2/LATS1.
-
Autorzy:
-
Mao J; Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Gansu Medical College, Pingliang, 744000, Gansu, China.
Qiu H; Department of General Medicine, Affiliated Hospital of Gansu Medical College, Pingliang, 744000, Gansu, China.
Guo L; Department of General Medicine, Affiliated Hospital of Gansu Medical College, Pingliang, 744000, Gansu, China. Electronic address: .
-
Źródło:
-
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2021 Nov 26; Vol. 580, pp. 74-80. Date of Electronic Publication: 2021 Oct 02.
-
Typ publikacji:
-
Journal Article; Research Support, Non-U.S. Gov't
-
Język:
-
English
-
Imprint Name(s):
-
Publication: <2002- >: San Diego, CA : Elsevier
Original Publication: New York, Academic Press.
-
MeSH Terms:
-
Adenocarcinoma of Lung/*genetics
Lung Neoplasms/*genetics
Methyltransferases/*genetics
Protein Serine-Threonine Kinases/*genetics
RNA, Long Noncoding/*genetics
RNA-Binding Proteins/*genetics
Animals ; Cell Line, Tumor ; Gene Expression Regulation, Neoplastic ; Humans ; Mice, Inbred BALB C ; Mice, Nude
-
Contributed Indexing:
-
Keywords: HCG11; IGF2BP2; LATS1; Long non-coding RNA; Lung adenocarcinoma; METTLE14
-
Substance Nomenclature:
-
0 (IGF2BP2 protein, human)
0 (RNA, Long Noncoding)
0 (RNA-Binding Proteins)
0 (long noncoding RNA HCG11, human)
EC 2.1.1.- (METTL14 protein, human)
EC 2.1.1.- (Methyltransferases)
EC 2.7.1.- (LATS1 protein, human)
EC 2.7.11.1 (Protein Serine-Threonine Kinases)
-
Entry Date(s):
-
Date Created: 20211008 Date Completed: 20211228 Latest Revision: 20211228
-
Update Code:
-
20240104
-
DOI:
-
10.1016/j.bbrc.2021.09.083
-
PMID:
-
34624573
-
Lung adenocarcinoma (LUAD) is a common malignancy the pathogenesis of which is terribly complicated and remains largely unclear. Long non-coding RNAs (lncRNAs) are a group of endogenous RNA molecules that are involved in various malignant processes. In this study, we explored the roles of lncRNA Human leukocyte antigen complex group 11 (HCG11) in LUAD. Our data revealed that lncRNA HCG11 expression was downregulated in LUAD, which was modulated by the hypermethylation of HCG11 promoter and Methyltransferase Like 14 (METTL14) mediated N6-methyladenosine (m6A) modification. The m6A modification of HCG11 promoted its nuclear exportation and binding by Insulin Like Growth Factor 2 MRNA Binding Protein 2 (IGF2BP2), resulting in increased stability. HCG11 could recruit IGF2BP2 to target Large Tumor Suppressor Kinase 1 (LATS1) mRNA to enhance the stability and promote the expression of LATS1. HCG11 served as a tumor suppressor to restrain tumor growth in LUAD by regulating LATS1. In summary, this study demonstrated that HCG11 mediated by METTL14 inhibited the growth of lung adenocarcinoma via IGF2BP2/LATS1.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2021 Elsevier Inc. All rights reserved.)
