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Tytuł:
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Evaluation of antimicrobial use in dairy cattle, beef cattle and broilers in Japan using dosage-based indicators.
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Autorzy:
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Abe R; Major in Veterinary Medical Science, Faculty of Agriculture, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan.
Fujimoto K; Environmental Science for Sustainable Development, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan.
Endo Y; Environmental Science for Sustainable Development, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan.
Sugiura K; Environmental Science for Sustainable Development, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan.; Nippon Institute for Biological Sciences, 9-222-1 Shin-machi, Ome, Tokyo 198-0024, Japan.
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Źródło:
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The Journal of veterinary medical science [J Vet Med Sci] 2021 Dec 02; Vol. 83 (12), pp. 1826-1837. Date of Electronic Publication: 2021 Oct 08.
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Typ publikacji:
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Journal Article
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Język:
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English
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Imprint Name(s):
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Original Publication: Tokyo : Japanese Society Of Veterinary Science
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MeSH Terms:
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Anti-Infective Agents*
Chickens*
Animals ; Anti-Bacterial Agents/therapeutic use ; Cattle ; Commerce ; Japan
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References:
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J Dairy Sci. 2016 Mar;99(3):2118-2130. (PMID: 26778315)
PLoS One. 2021 Apr 16;16(4):e0245105. (PMID: 33861745)
Lancet. 2016 Jan 9;387(10014):176-87. (PMID: 26603922)
Front Vet Sci. 2020 Jan 29;7:10. (PMID: 32083099)
Prev Vet Med. 2020 Mar;176:104937. (PMID: 32126401)
PLoS One. 2020 Oct 30;15(10):e0241644. (PMID: 33125427)
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Contributed Indexing:
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Keywords: Japan; antimicrobial use; broiler; cattle; defined daily dose
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Substance Nomenclature:
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0 (Anti-Bacterial Agents)
0 (Anti-Infective Agents)
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Entry Date(s):
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Date Created: 20211011 Date Completed: 20211203 Latest Revision: 20220122
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Update Code:
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20240104
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PubMed Central ID:
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PMC8762408
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DOI:
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10.1292/jvms.21-0385
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PMID:
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34629334
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The sales amount of antimicrobials intended for use in dairy cattle, beef cattle and broilers from 2008 to 2019 was evaluated for each antimicrobial class and administration route using dosage-based indicators. Our results revealed that the antimicrobial sales amount sold for use in dairy cattle in 2019 in terms of total weight of active ingredient, the number of defined daily doses (DDDs) (theoretical amount of biomass subjected to antimicrobial treatment in a year) and the number of treatment days (TDs) (theoretical number of days of treatment that an animal is subjected to in a year) calculated using Japanese DDD values (DDDjp values) was 36,751 kg, 8,261,848,000 kg·days and 15.5 days, respectively. Likewise, the antimicrobial sales amount sold for use in beef cattle and broilers in 2019 in terms of these metrics was 33,403 kg, 3,928,248,000 kg·days and 3.61 days, and 69,773 kg, 2,947,848,000 kg·days and 10.66 days, respectively. There was a considerable difference between the number of DDDs calculated using DDDjp values and that calculated using European DDD values (DDDvet values) for antimicrobial products sold for use in dairy and beef cattle. Our results also revealed that the sales amount of some antimicrobials, such as cephalosporins and quinolones represented larger proportions when calculated using dosage-based indicators than when calculated using the weight of active ingredient. Considering that Japanese veterinarians and farmers are more likely to conform to the Japanese dosage recommendations rather than the European ones, these results indicate the need for using dosage-based metrics, in particular metrics based on Japanese dosages rather than European dosages.