The ascending arousal system shapes neural dynamics to mediate awareness of cognitive states.

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Tytuł:: The ascending arousal system shapes neural dynamics to mediate awareness of cognitive states.
Autorzy:: Munn BR; Complex Systems Research Group, The University of Sydney, Sydney, NSW, Australia. .; Brain and Mind Centre, The University of Sydney, Sydney, NSW, Australia. .
Müller EJ; Complex Systems Research Group, The University of Sydney, Sydney, NSW, Australia.; Brain and Mind Centre, The University of Sydney, Sydney, NSW, Australia.
Wainstein G; Complex Systems Research Group, The University of Sydney, Sydney, NSW, Australia.; Brain and Mind Centre, The University of Sydney, Sydney, NSW, Australia.
Shine JM; Complex Systems Research Group, The University of Sydney, Sydney, NSW, Australia. .; Brain and Mind Centre, The University of Sydney, Sydney, NSW, Australia. .
Źródło:: Nature communications [Nat Commun] 2021 Oct 14; Vol. 12 (1), pp. 6016. Date of Electronic Publication: 2021 Oct 14.
Typ publikacji:: Journal Article
Język:: English
Imprint Name(s):: Original Publication: [London] : Nature Pub. Group
MeSH Terms:: Arousal*
Cognition*
Neural Pathways*
Brain/*physiology
Adolescent ; Adult ; Aged ; Attention ; Basal Forebrain ; Brain Stem ; Female ; Humans ; Locus Coeruleus ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Young Adult
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Entry Date(s):: Date Created: 20211015 Date Completed: 20211112 Latest Revision: 20211112
Update Code:: 20240104
PubMed Central ID:: PMC8516926
DOI:: 10.1038/s41467-021-26268-x
PMID:: 34650039
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Models of cognitive function typically focus on the cerebral cortex and hence overlook functional links to subcortical structures. This view does not consider the role of the highly-conserved ascending arousal system's role and the computational capacities it provides the brain. We test the hypothesis that the ascending arousal system modulates cortical neural gain to alter the low-dimensional energy landscape of cortical dynamics. Here we use spontaneous functional magnetic resonance imaging data to study phasic bursts in both locus coeruleus and basal forebrain, demonstrating precise time-locked relationships between brainstem activity, low-dimensional energy landscapes, network topology, and spatiotemporal travelling waves. We extend our analysis to a cohort of experienced meditators and demonstrate locus coeruleus-mediated network dynamics were associated with internal shifts in conscious awareness. Together, these results present a view of brain organization that highlights the ascending arousal system's role in shaping both the dynamics of the cerebral cortex and conscious awareness.
(© 2021. The Author(s).)

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