Prognostic nutritional index predicts clinical outcomes in patients with cerebral venous sinus thrombosis.

Szczegóły
Abstrakt

Tytuł:: Prognostic nutritional index predicts clinical outcomes in patients with cerebral venous sinus thrombosis.
Autorzy:: Zhao J; Department of Neurology, the First Affiliated Hospital of Zhengzhou University, No.1 Eastern Jianshe Road, Zhengzhou, 450052, Henan, China.
Liu K; Department of Neurology, the First Affiliated Hospital of Zhengzhou University, No.1 Eastern Jianshe Road, Zhengzhou, 450052, Henan, China.
Li S; Department of Neurology, the First Affiliated Hospital of Zhengzhou University, No.1 Eastern Jianshe Road, Zhengzhou, 450052, Henan, China.
Gao Y; Department of Neurology, the First Affiliated Hospital of Zhengzhou University, No.1 Eastern Jianshe Road, Zhengzhou, 450052, Henan, China.
Zhao L; Department of Neurology, the First Affiliated Hospital of Zhengzhou University, No.1 Eastern Jianshe Road, Zhengzhou, 450052, Henan, China.
Liu H; Department of Neurology, the First Affiliated Hospital of Zhengzhou University, No.1 Eastern Jianshe Road, Zhengzhou, 450052, Henan, China.
Fang H; Department of Neurology, the First Affiliated Hospital of Zhengzhou University, No.1 Eastern Jianshe Road, Zhengzhou, 450052, Henan, China.
Wu J; Department of Neurology, the First Affiliated Hospital of Zhengzhou University, No.1 Eastern Jianshe Road, Zhengzhou, 450052, Henan, China.
Sun S; Department of Neurology, the First Affiliated Hospital of Zhengzhou University, No.1 Eastern Jianshe Road, Zhengzhou, 450052, Henan, China.
Li Y; Department of Neurology, the First Affiliated Hospital of Zhengzhou University, No.1 Eastern Jianshe Road, Zhengzhou, 450052, Henan, China.
Song B; Department of Neurology, the First Affiliated Hospital of Zhengzhou University, No.1 Eastern Jianshe Road, Zhengzhou, 450052, Henan, China. .
Xu Y; Department of Neurology, the First Affiliated Hospital of Zhengzhou University, No.1 Eastern Jianshe Road, Zhengzhou, 450052, Henan, China. .
Źródło:: BMC neurology [BMC Neurol] 2021 Oct 21; Vol. 21 (1), pp. 404. Date of Electronic Publication: 2021 Oct 21.
Typ publikacji:: Journal Article
Język:: English
Imprint Name(s):: Original Publication: London : BioMed Central, [2001-
MeSH Terms:: Nutrition Assessment*
Sinus Thrombosis, Intracranial*/diagnostic imaging
Humans ; Kaplan-Meier Estimate ; Prognosis ; Retrospective Studies
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Contributed Indexing:: Keywords: Acute/subacute; Cerebral venous sinus thrombosis; Prognosis; Prognostic nutritional index; Risk factors
Entry Date(s):: Date Created: 20211022 Date Completed: 20211025 Latest Revision: 20211026
Update Code:: 20240105
PubMed Central ID:: PMC8529735
DOI:: 10.1186/s12883-021-02436-w
PMID:: 34674659
: Czasopismo naukowe

Pełny tekst

Background: Lower prognostic nutritional index (PNI) is related to the poor prognosis of cardiovascular diseases. However, little is known about PNI and its relationship with the prognosis of cerebral venous sinus thrombosis (CVST).
Methods: CVST patients were retrospectively identified from January 2013 till June 2019. Patients in the acute / subacute phase were selected as subjects. Poor prognosis was defined as a modified Rankin Scale (mRS) of 3-6. Multivariate logistic regression analysis was used to confirm if lower PNI was associated with a poor prognosis.
Results: A total of 297 subjects with follow-up data were enrolled. Thirty-three (11.1%) had a poor outcome. Multivariate logistic regression analysis suggested that PNI was an important predictive factor of poor outcome in acute/subacute CVST (odds ratio, 0.903; 95% CI, 0.833-0.978; P = 0.012). The optimal cut-off value for predicting the poor prognosis of PNI was 44.2. Kaplan-Meier analysis and log-rank test suggested that the lower the PNI value, the higher the mortality rate (P < 0.001). In addition, the nomogram that was set up showed that lower PNI was an index of poor prognosis. The c-index for acute/subacute patients with CVST was 0.872.
Conclusion: Lower PNI is correlated with a higher risk of adverse clinical outcomes in patients with acute/subacute CVST.
(© 2021. The Author(s).)

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