Corticospinal neuron subpopulation-specific developmental genes prospectively indicate mature segmentally specific axon projection targeting.

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Tytuł:: Corticospinal neuron subpopulation-specific developmental genes prospectively indicate mature segmentally specific axon projection targeting.
Autorzy:: Sahni V; Department of Stem Cell and Regenerative Biology, Center for Brain Science, Harvard University, Cambridge, MA 02138, USA.
Shnider SJ; Department of Stem Cell and Regenerative Biology, Center for Brain Science, Harvard University, Cambridge, MA 02138, USA.
Jabaudon D; Department of Stem Cell and Regenerative Biology, Center for Brain Science, Harvard University, Cambridge, MA 02138, USA.
Song JHT; Department of Stem Cell and Regenerative Biology, Center for Brain Science, Harvard University, Cambridge, MA 02138, USA.
Itoh Y; Department of Stem Cell and Regenerative Biology, Center for Brain Science, Harvard University, Cambridge, MA 02138, USA.
Greig LC; Department of Stem Cell and Regenerative Biology, Center for Brain Science, Harvard University, Cambridge, MA 02138, USA.
Macklis JD; Department of Stem Cell and Regenerative Biology, Center for Brain Science, Harvard University, Cambridge, MA 02138, USA. Electronic address: jeffrey_.
Źródło:: Cell reports [Cell Rep] 2021 Oct 19; Vol. 37 (3), pp. 109843.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Video-Audio Media
Język:: English
Imprint Name(s):: Original Publication: [Cambridge, MA] : Cell Press, c 2012-
MeSH Terms:: Gene Expression Regulation, Developmental*
Neuronal Outgrowth*
Axons/*metabolism
Pyramidal Tracts/*metabolism
Sensorimotor Cortex/*metabolism
White Matter/*metabolism
Age Factors ; Animals ; Bone Morphogenetic Protein Receptors/genetics ; Bone Morphogenetic Protein Receptors/metabolism ; Cell Separation ; Female ; Flow Cytometry ; Male ; Mice, Inbred C57BL ; Mice, Knockout ; Nerve Tissue Proteins/genetics ; Nerve Tissue Proteins/metabolism ; Neuroanatomical Tract-Tracing Techniques ; Pyramidal Tracts/growth & development ; Sensorimotor Cortex/growth & development ; Transcription, Genetic ; White Matter/growth & development ; Mice
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Grant Information:: R01 NS049553 United States NS NINDS NIH HHS; R01 NS045523 United States NS NINDS NIH HHS; K12 HD093427 United States HD NICHD NIH HHS; F31 NS063516 United States NS NINDS NIH HHS; F31 NS080343 United States NS NINDS NIH HHS; R01 NS104055 United States NS NINDS NIH HHS; R01 NS075672 United States NS NINDS NIH HHS; DP1 NS106665 United States NS NINDS NIH HHS
Contributed Indexing:: Keywords: bulbar-cervical; cortical development; cortical output circuitry; corticospinal axon guidance; corticospinal circuitry; corticospinal diversity; corticospinal tract; molecular controls over neuronal diversity; motor control; thoracolumbar
Substance Nomenclature:: 0 (Crim1 protein, mouse)
0 (Klhl14 protein, mouse)
0 (Nerve Tissue Proteins)
EC 2.7.11.30 (Bone Morphogenetic Protein Receptors)
Entry Date(s):: Date Created: 20211023 Date Completed: 20220215 Latest Revision: 20240226
Update Code:: 20240226
PubMed Central ID:: PMC8653526
DOI:: 10.1016/j.celrep.2021.109843
PMID:: 34686320
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For precise motor control, distinct subpopulations of corticospinal neurons (CSN) must extend axons to distinct spinal segments, from proximal targets in the brainstem and cervical cord to distal targets in thoracic and lumbar spinal segments. We find that developing CSN subpopulations exhibit striking axon targeting specificity in spinal white matter, which establishes the foundation for durable specificity of adult corticospinal circuitry. Employing developmental retrograde and anterograde labeling, and their distinct neocortical locations, we purified developing CSN subpopulations using fluorescence-activated cell sorting to identify genes differentially expressed between bulbar-cervical and thoracolumbar-projecting CSN subpopulations at critical developmental times. These segmentally distinct CSN subpopulations are molecularly distinct from the earliest stages of axon extension, enabling prospective identification even before eventual axon targeting decisions are evident in the spinal cord. This molecular delineation extends beyond simple spatial separation of these subpopulations in the cortex. Together, these results identify candidate molecular controls over segmentally specific corticospinal axon projection targeting.
Competing Interests: Declaration of interests The authors declare no competing interests.
(Copyright © 2021 The Author(s). Published by Elsevier Inc. All rights reserved.)

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