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Tytuł pozycji:

Local and systemic effects of interleukin-6 (IL-6) in inflammation and cancer.

Tytuł:
Local and systemic effects of interleukin-6 (IL-6) in inflammation and cancer.
Autorzy:
Rose-John S; Biochemical Institute, University of Kiel, Germany.
Źródło:
FEBS letters [FEBS Lett] 2022 Mar; Vol. 596 (5), pp. 557-566. Date of Electronic Publication: 2021 Nov 12.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Review
Język:
English
Imprint Name(s):
Publication: Jan. 2016- : West Sussex : John Wiley & Sons Ltd.
Original Publication: Amsterdam, North-Holland on behalf of the Federation of European Biochemical Societies.
MeSH Terms:
Interleukin-6*/metabolism
Neoplasms*/genetics
Animals ; Cytokine Receptor gp130/genetics ; Cytokine Receptor gp130/metabolism ; Cytokines/metabolism ; Inflammation/metabolism ; Mice ; Receptors, Interleukin-6/metabolism
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Contributed Indexing:
Keywords: cancer; inflammation; interleukin-6; pancreatitis; trans-signaling
Substance Nomenclature:
0 (Cytokines)
0 (Interleukin-6)
0 (Receptors, Interleukin-6)
133483-10-0 (Cytokine Receptor gp130)
Entry Date(s):
Date Created: 20211105 Date Completed: 20220503 Latest Revision: 20220503
Update Code:
20240105
DOI:
10.1002/1873-3468.14220
PMID:
34738234
Czasopismo naukowe
Interleukin-6 (IL-6) is an inflammatory cytokine, the level of which is highly elevated in most, if not all, inflammatory states. IL-6 triggers cell type-specific responses and acts on target cells via a specific interleukin-6 receptor (IL-6R), which, together with IL-6, binds to and induces the dimerization of a second receptor subunit, gp130. IL-6 also binds to soluble IL-6R, and this complex interacts with gp130, regardless of IL-6R expression. This allows cells that do not express IL-6R and would be otherwise insensitive to IL-6 to respond to it. We have generated a constitutively active version of gp130 by forced leucine-zipper-mediated dimerization, named L-gp130. Once inserted into the Rosa26 locus of mice, L-gp130 can be activated in a cell-autonomous manner by crossing these mice with any Cre-recombinase transgenic mouse strain. Activation of gp130 in hepatocytes produced liver-specific effects such as the induction of acute-phase proteins, but it also had profound systemic effects on the immune system. Such local and systemic effects of interleukin-6 will be reviewed.
(© 2021 The Authors. FEBS Letters published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies.)

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