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Tytuł:
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Fast determination of functionality-type × molecular-weight distribution of propoxylates with varying numbers of hydroxyl end-groups using gradient-normal-phase liquid chromatography × ultra-high pressure size-exclusion chromatography.
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Autorzy:
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Groeneveld G; University of Amsterdam, Van 't Hoff Institute for Molecular Sciences, Science Park 904, 1098 XH Amsterdam, the Netherlands. Electronic address: .
Salome R; Dow, Analytical Science, P.O. Box 48, 4530 AA Terneuzen, the Netherlands.
Dunkle MN; Dow, Analytical Science, P.O. Box 48, 4530 AA Terneuzen, the Netherlands.
Bashir M; Dow, Analytical Science, P.O. Box 48, 4530 AA Terneuzen, the Netherlands.
Gargano AFG; University of Amsterdam, Van 't Hoff Institute for Molecular Sciences, Science Park 904, 1098 XH Amsterdam, the Netherlands.
Pursch M; Dow, Analytical Science, 65201 Wiesbaden, Germany.
Mes EPC; Dow, Analytical Science, P.O. Box 48, 4530 AA Terneuzen, the Netherlands.
Schoenmakers PJ; University of Amsterdam, Van 't Hoff Institute for Molecular Sciences, Science Park 904, 1098 XH Amsterdam, the Netherlands.
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Źródło:
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Journal of chromatography. A [J Chromatogr A] 2021 Dec 06; Vol. 1659, pp. 462644. Date of Electronic Publication: 2021 Oct 25.
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Typ publikacji:
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Journal Article
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Język:
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English
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Imprint Name(s):
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Original Publication: Amsterdam ; New York : Elsevier, 1993-
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MeSH Terms:
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Polymers*
Chromatography, Gel ; Chromatography, Liquid ; Molecular Weight
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Contributed Indexing:
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Keywords: Comprehensive two-dimensional liquid chromatography; Functionality-type distribution; NPLC × SEC; Poly-propylene oxide; Propoxylates; Two-dimensional distributions
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Substance Nomenclature:
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0 (Polymers)
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Entry Date(s):
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Date Created: 20211105 Date Completed: 20211130 Latest Revision: 20211130
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Update Code:
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20240105
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DOI:
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10.1016/j.chroma.2021.462644
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PMID:
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34739964
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Understanding the relation between chemical characteristics and properties of synthetic polymers is one of the challenges faced by analytical chemists in industry. This is a complex task, as polymers are not synthesized as single molecule, but are populations of chemically similar compounds with distributions over several properties. The latter include, for example, molecular weight, nature of end-groups (functionality), and chemical composition. In this paper, comprehensive two-dimensional liquid chromatography was used to determine the combined functionality-type and molecular-weight distributions of hydroxy‑functionalized propoxylates. Propoxylates derived from different initiators (one up to eight terminal hydroxyl groups) were separated in the first dimension using a gradient normal-phase LC separation (NPLC). In the second dimension ultra-high pressure size-exclusion chromatography separation (UHPSEC), further speciating distributions based on molecular size. The developed NPLC × SEC method with evaporative light-scattering detection can be used for the fast screening (< 30 min) of mutually dependent functionality-type and molecular-weight distributions of unknown propoxylates.
Competing Interests: Declaration of Competing Interest Statement: “The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.”
(Copyright © 2021. Published by Elsevier B.V.)
