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Tytuł:
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A 90-day subchronic toxicity study of Myrrh in F344 rats.
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Autorzy:
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Mitsumoto T; Division of Pathology, National Institute of Health Sciences, 3-25-26 Tonomachi, Kawasaki-ku, Kawasaki-shi, Kanagawa, 210-9501, Japan; Faculty of Animal Health Technology, Yamazaki University of Animal Health Technology, 4-7-2, Minami-osawa, Hachihoji, Tokyo, 192-0364, Japan.
Ishii Y; Division of Pathology, National Institute of Health Sciences, 3-25-26 Tonomachi, Kawasaki-ku, Kawasaki-shi, Kanagawa, 210-9501, Japan. Electronic address: .
Namiki M; Division of Pathology, National Institute of Health Sciences, 3-25-26 Tonomachi, Kawasaki-ku, Kawasaki-shi, Kanagawa, 210-9501, Japan.
Nakamura K; Division of Pathology, National Institute of Health Sciences, 3-25-26 Tonomachi, Kawasaki-ku, Kawasaki-shi, Kanagawa, 210-9501, Japan; Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu-shi, Tokyo, 183-8509, Japan.
Takasu S; Division of Pathology, National Institute of Health Sciences, 3-25-26 Tonomachi, Kawasaki-ku, Kawasaki-shi, Kanagawa, 210-9501, Japan.
Ogawa K; Division of Pathology, National Institute of Health Sciences, 3-25-26 Tonomachi, Kawasaki-ku, Kawasaki-shi, Kanagawa, 210-9501, Japan.
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Źródło:
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Regulatory toxicology and pharmacology : RTP [Regul Toxicol Pharmacol] 2021 Dec; Vol. 127, pp. 105076. Date of Electronic Publication: 2021 Nov 04.
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Typ publikacji:
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Journal Article
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Język:
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English
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Imprint Name(s):
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Publication: <2003>- : Amsterdam : Elsevier
Original Publication: New York : Academic Press, [c1981-
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MeSH Terms:
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No-Observed-Adverse-Effect Level*
Commiphora/*toxicity
Flavoring Agents/*toxicity
Resins, Plant/*toxicity
Animals ; Dose-Response Relationship, Drug ; Female ; Hyalin/drug effects ; Kidney/drug effects ; Male ; Organ Size/drug effects ; Particle Size ; Random Allocation ; Rats ; Rats, Inbred F344
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Contributed Indexing:
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Keywords: F344 rats; Flavoring agent; Food additive; Myrrh; Subchronic toxicity
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Substance Nomenclature:
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0 (Flavoring Agents)
0 (Resins, Plant)
9000-45-7 (myrrh resin)
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Entry Date(s):
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Date Created: 20211107 Date Completed: 20220119 Latest Revision: 20220119
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Update Code:
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20240105
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DOI:
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10.1016/j.yrtph.2021.105076
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PMID:
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34742868
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Myrrh is a flavoring agent and food additive. Here, we performed a subchronic toxicity study of Myrrh in male and female F344 rats by feeding at 5,000, 15,000 and 50,000 ppm for 90 days. No deaths or clinical signs were observed. Suppression of body weight gain was observed from the early phase of administration in both males and females in the 50,000 ppm group. Because there were no obvious changes in food intake in any of the Myrrh groups compared with the control group, suppression of body weight gain was considered an adverse effect of Myrrh. Hematology and serum biochemistry parameters with significant changes observed in the Myrrh groups were considered to have no toxicological significance. We observed a significant increase in relative kidney weight in male rats treated with 50,000 ppm Myrrh; this effect was considered to be related to the appearance of hyaline droplets in the epithelium of the proximal tubules histopathologically observed in this group. Immunohistochemical staining with anti-α 2u -globulin antibodies suggested that these hyaline droplets were caused by factors other than α 2u -globulin deposition. Thus, the no-observed-adverse-effect level of Myrrh was determined to be 15,000 ppm (males: 0.85 g/kg/day, females: 0.95 g/kg/day).
(Copyright © 2021 Elsevier Inc. All rights reserved.)
