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Tytuł:
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Treatment with crocin suppresses diabetic nephropathy progression via modulating TGF-β1 and oxidative stress in an experimental model of pinealectomized diabetic rats.
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Autorzy:
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Ali Hammood Keelo RM; Department of Medical Biochemistry, Faculty of Medicine, Karabuk University, Karabuk, Turkey.
Elbe H; Department of Histology and Embryology, Faculty of Medicine, Mugla Sıtkı Kocman University, Mugla, Turkey.
Bicer Y; Department of Medical Biochemistry, Faculty of Medicine, Karabuk University, Karabuk, Turkey.
Yigitturk G; Department of Histology and Embryology, Faculty of Medicine, Mugla Sıtkı Kocman University, Mugla, Turkey.
Koca O; Department of Biochemistry, Karabuk University Education and Research Hospital, Karabuk, Turkey.
Karayakali M; Department of Medical Biochemistry, Faculty of Medicine, Karabuk University, Karabuk, Turkey.
Acar D; Department of Anatomy, Vocational School of Health Services, Karabuk University, Karabuk, Turkey.
Altinoz E; Department of Medical Biochemistry, Faculty of Medicine, Karabuk University, Karabuk, Turkey. Electronic address: .
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Źródło:
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Chemico-biological interactions [Chem Biol Interact] 2022 Jan 05; Vol. 351, pp. 109733. Date of Electronic Publication: 2021 Oct 29.
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Typ publikacji:
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Journal Article
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Język:
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English
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Imprint Name(s):
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Publication: Limerick : Elsevier
Original Publication: Amsterdam, Elsevier.
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MeSH Terms:
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Antioxidants/*therapeutic use
Carotenoids/*therapeutic use
Diabetic Nephropathies/*prevention & control
Hypoglycemic Agents/*therapeutic use
Oxidative Stress/*drug effects
Transforming Growth Factor beta1/*metabolism
Animals ; Blood Glucose/metabolism ; Diabetes Mellitus, Experimental/chemically induced ; Diabetes Mellitus, Experimental/drug therapy ; Diabetes Mellitus, Experimental/metabolism ; Diabetes Mellitus, Experimental/surgery ; Diabetic Nephropathies/chemically induced ; Diabetic Nephropathies/metabolism ; Diabetic Nephropathies/surgery ; Kidney/drug effects ; Kidney/metabolism ; Male ; Pinealectomy ; Rats, Wistar ; Streptozocin ; Rats
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Contributed Indexing:
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Keywords: Crocin; Diabetes; MDA; Pinealectomy; ROS; TGF-β1
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Substance Nomenclature:
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0 (Antioxidants)
0 (Blood Glucose)
0 (Hypoglycemic Agents)
0 (Transforming Growth Factor beta1)
36-88-4 (Carotenoids)
5W494URQ81 (Streptozocin)
877GWI46C2 (crocin)
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Entry Date(s):
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Date Created: 20211108 Date Completed: 20220103 Latest Revision: 20240226
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Update Code:
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20240226
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DOI:
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10.1016/j.cbi.2021.109733
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PMID:
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34743986
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One of the most common complications of diabetes is diabetic nephropathy (DN). Uncontrolled hyperglycemia leads to histopathologic alterations in the kidney that prevent normal renal function. This study aimed to explore the effects of crocin treatment via virtue of its numerous beneficial properties in streptozotocin-induced pinealectomized diabetic rats. The pinealectomy procedure was conducted on the first day of the study. On the 30th day following pinealectomy, streptozotocin (STZ) (50 mg/kg) was administered intraperitoneally in Wistar rats for induction of diabetes. Diabetes was confirmed on the 3rd day following STZ administration by determining the glucose levels. Daily crocin treatment intraperitoneally for 15 days (50 mg/kg) ameliorated impaired renal oxidant/antioxidant balance, reduced TGF-β1 immuno-staining around tubules, and promoted improvement of renal architecture. Moreover, crocin administration improved altered renal function parameters, including serum Cr and BUN, and also increased creatinine clearance. In conclusion, the protective effects of crocin on diabetic nephropathy might be associated with its powerful antioxidant properties, its ability to improve tissue antioxidant status, and its ability to prevent inflammatory pathways.
(Copyright © 2021 Elsevier B.V. All rights reserved.)
