Informacja

Drogi użytkowniku, aplikacja do prawidłowego działania wymaga obsługi JavaScript. Proszę włącz obsługę JavaScript w Twojej przeglądarce.

Tytuł pozycji:

Cardiac Fibrosis Is a Risk Factor for Severe COVID-19.

Tytuł:
Cardiac Fibrosis Is a Risk Factor for Severe COVID-19.
Autorzy:
Mustroph J; Department of Internal Medicine II, University Hospital Regensburg, Regensburg, Germany.
Hupf J; Emergency Department, University Hospital Regensburg, Regensburg, Germany.
Baier MJ; Department of Internal Medicine II, University Hospital Regensburg, Regensburg, Germany.
Evert K; Institute of Pathology, University of Regensburg, Regensburg, Germany.
Brochhausen C; Institute of Pathology, University of Regensburg, Regensburg, Germany.
Broeker K; Department of Physiology, University of Regensburg, Regensburg, Germany.
Meindl C; Department of Internal Medicine II, University Hospital Regensburg, Regensburg, Germany.
Seither B; Department of Internal Medicine II, University Hospital Regensburg, Regensburg, Germany.
Jungbauer C; Department of Internal Medicine II, University Hospital Regensburg, Regensburg, Germany.
Evert M; Institute of Pathology, University of Regensburg, Regensburg, Germany.
Maier LS; Department of Internal Medicine II, University Hospital Regensburg, Regensburg, Germany.
Wagner S; Department of Internal Medicine II, University Hospital Regensburg, Regensburg, Germany.
Źródło:
Frontiers in immunology [Front Immunol] 2021 Oct 22; Vol. 12, pp. 740260. Date of Electronic Publication: 2021 Oct 22 (Print Publication: 2021).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
Język:
English
Imprint Name(s):
Original Publication: [Lausanne : Frontiers Research Foundation]
MeSH Terms:
COVID-19/*physiopathology
Heart Ventricles/*pathology
Myocardium/*pathology
Pulmonary Fibrosis/*physiopathology
SARS-CoV-2/*physiology
Adult ; Aged ; COVID-19/immunology ; Female ; Fibrosis ; Heart Ventricles/metabolism ; Humans ; Interleukin-1 Receptor-Like 1 Protein/genetics ; Interleukin-1 Receptor-Like 1 Protein/metabolism ; Male ; Middle Aged ; Myocardium/metabolism ; Neuropilin-1/genetics ; Neuropilin-1/metabolism ; Pulmonary Fibrosis/immunology ; Risk ; Severity of Illness Index ; Transforming Growth Factor beta1/genetics ; Transforming Growth Factor beta1/metabolism ; Viral Load
References:
Cell Physiol Biochem. 2018;46(5):2103-2113. (PMID: 29723859)
Science. 2020 Nov 13;370(6518):856-860. (PMID: 33082293)
JAMA Cardiol. 2020 Nov 1;5(11):1265-1273. (PMID: 32730619)
Nat Rev Nephrol. 2016 Jun;12(6):325-38. (PMID: 27108839)
ESC Heart Fail. 2021 Feb;8(1):309-316. (PMID: 33215884)
Int J Mol Sci. 2019 Sep 06;20(18):. (PMID: 31489895)
Circulation. 2015 Feb 17;131(7):643-55. (PMID: 25589557)
Nat Rev Drug Discov. 2008 Oct;7(10):827-40. (PMID: 18827826)
Free Radic Biol Med. 2012 Oct 1;53(7):1489-99. (PMID: 22728268)
Crit Care. 2020 Aug 28;24(1):527. (PMID: 32859259)
Mod Pathol. 2021 Jul;34(7):1345-1357. (PMID: 33727695)
JAMA Cardiol. 2017 Sep 1;2(9):995-1006. (PMID: 28768311)
Circ Res. 2020 May 8;126(10):1443-1455. (PMID: 32252591)
J Cardiovasc Ultrasound. 2016 Dec;24(4):303-311. (PMID: 28090258)
Tech Coloproctol. 2020 Nov;24(11):1217-1218. (PMID: 32506344)
J Biochem. 2010 Jun;147(6):781-92. (PMID: 20410014)
J Leukoc Biol. 2008 Jul;84(1):302-10. (PMID: 18436584)
Front Immunol. 2018 Oct 24;9:2432. (PMID: 30405626)
Int J Cardiol Heart Vasc. 2020 Jul 14;29:100589. (PMID: 32724831)
Virchows Arch. 2021 Jul;479(1):97-108. (PMID: 33471172)
J Transl Med. 2016 Aug 27;14(1):248. (PMID: 27567668)
Cells. 2020 Jul 10;9(7):. (PMID: 32664340)
Int J Biochem Cell Biol. 2019 Nov;116:105619. (PMID: 31561019)
Vasc Health Risk Manag. 2008;4(6):1289-300. (PMID: 19337543)
J Am Coll Cardiol. 2014 Jun 24;63(24):2742-4. (PMID: 24681139)
Circ Res. 2021 Apr 16;128(8):1139-1155. (PMID: 33593074)
PLoS One. 2019 Jul 18;14(7):e0219483. (PMID: 31318905)
EMBO Mol Med. 2020 Oct 7;12(10):e10865. (PMID: 32955172)
J Exp Med. 2020 Feb 13;217(3):e20190103. (PMID: 32997468)
Circulation. 2002 Dec 3;106(23):2961-6. (PMID: 12460879)
Redox Biol. 2014 Jan 20;2:267-72. (PMID: 24494202)
Eur J Heart Fail. 2020 May;22(5):911-915. (PMID: 32275347)
J Clin Invest. 2017 Oct 2;127(10):3770-3783. (PMID: 28891814)
Growth Factors. 2011 Oct;29(5):196-202. (PMID: 21740331)
Lancet Child Adolesc Health. 2020 Oct;4(10):790-794. (PMID: 32828177)
Cell. 2008 May 2;133(3):462-74. (PMID: 18455987)
Cell. 2020 Apr 16;181(2):271-280.e8. (PMID: 32142651)
Biochem J. 2007 Aug 15;406(1):105-14. (PMID: 17501721)
World J Gastroenterol. 2021 Jun 28;27(24):3516-3529. (PMID: 34239266)
Circulation. 2021 Feb 9;143(6):609-612. (PMID: 33332151)
J Card Fail. 2020 Jun;26(6):470-475. (PMID: 32315733)
Intensive Care Med. 2020 Jul;46(7):1464-1465. (PMID: 32424482)
Sci Rep. 2021 Jan 12;11(1):617. (PMID: 33436786)
J Card Fail. 2016 Nov;22(11):901-907. (PMID: 26952240)
Int J Mol Sci. 2021 Apr 26;22(9):. (PMID: 33925804)
Blood. 2012 Jan 26;119(4):1064-74. (PMID: 22134166)
Contributed Indexing:
Keywords: COVID-19; NRP-1; SARS-CoV-2; TGF-β1; fibrosis; heart
Substance Nomenclature:
0 (Interleukin-1 Receptor-Like 1 Protein)
0 (Transforming Growth Factor beta1)
144713-63-3 (Neuropilin-1)
Entry Date(s):
Date Created: 20211108 Date Completed: 20211125 Latest Revision: 20211125
Update Code:
20240105
PubMed Central ID:
PMC8569622
DOI:
10.3389/fimmu.2021.740260
PMID:
34745111
Czasopismo naukowe
Increased left ventricular fibrosis has been reported in patients hospitalized with coronavirus disease 2019 (COVID-19). It is unclear whether this fibrosis is a consequence of severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) infection or a risk factor for severe disease progression. We observed increased fibrosis in the left ventricular myocardium of deceased COVID-19 patients, compared with matched controls. We also detected increased mRNA levels of soluble interleukin-1 receptor-like 1 (sIL1-RL1) and transforming growth factor β1 (TGF-β1) in the left ventricular myocardium of deceased COVID-19 patients. Biochemical analysis of blood sampled from patients admitted to the emergency department (ED) with COVID-19 revealed highly elevated levels of TGF-β1 mRNA in these patients compared to controls. Left ventricular strain measured by echocardiography as a marker of pre-existing cardiac fibrosis correlated strongly with blood TGF-β1 mRNA levels and predicted disease severity in COVID-19 patients. In the left ventricular myocardium and lungs of COVID-19 patients, we found increased neuropilin-1 (NRP-1) RNA levels, which correlated strongly with the prevalence of pulmonary SARS-CoV-2 nucleocapsid. Cardiac and pulmonary fibrosis may therefore predispose these patients to increased cellular viral entry in the lung, which may explain the worse clinical outcome observed in our cohort. Our study demonstrates that patients at risk of clinical deterioration can be identified early by echocardiographic strain analysis and quantification of blood TGF-β1 mRNA performed at the time of first medical contact.
Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
(Copyright © 2021 Mustroph, Hupf, Baier, Evert, Brochhausen, Broeker, Meindl, Seither, Jungbauer, Evert, Maier and Wagner.)

Ta witryna wykorzystuje pliki cookies do przechowywania informacji na Twoim komputerze. Pliki cookies stosujemy w celu świadczenia usług na najwyższym poziomie, w tym w sposób dostosowany do indywidualnych potrzeb. Korzystanie z witryny bez zmiany ustawień dotyczących cookies oznacza, że będą one zamieszczane w Twoim komputerze. W każdym momencie możesz dokonać zmiany ustawień dotyczących cookies