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Tytuł:
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An engram of intentionally forgotten information.
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Autorzy:
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Ten Oever S; Max Planck Institute for Psycholinguistics, Wundtlaan 1, 6525XD, Nijmegen, The Netherlands. .; Donders Centre for Cognitive Neuroimaging, Radboud University, Kapittelweg 29, 6525EN, Nijmegen, The Netherlands. .; Department of Cognitive Neuroscience, Faculty of Psychology and Neuroscience, Maastricht University, Oxfordlaan 55, 6229EV, Maastricht, The Netherlands. .
Sack AT; Department of Cognitive Neuroscience, Faculty of Psychology and Neuroscience, Maastricht University, Oxfordlaan 55, 6229EV, Maastricht, The Netherlands.; Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience (MHeNs), Brain and Nerve Centre, Maastricht University Medical Centre+ (MUMC+), Debyelaan 25, 6229HX, Maastricht, The Netherlands.
Oehrn CR; Department of Neurology, Philipps-University of Marburg, Biegenstraße 10, 35037, Marburg, Germany.; Center for Mind, Brain and Behavior (CMBB), Philipps-University Marburg, Biegenstraße 10, 35037, Marburg, Germany.
Axmacher N; Department of Neuropsychology, Faculty of Psychology, Institute of Cognitive Neuroscience, Ruhr University Bochum, Universitätsstraße 150, 44801, Bochum, Germany. .; State Key Laboratory of Cognitive Neuroscience and Learning and IDG/McGovern Institute for Brain Research, Beijing Normal University, 19 Xinjiekou Outer St, Beijing, 100875, China. .
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Źródło:
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Nature communications [Nat Commun] 2021 Nov 08; Vol. 12 (1), pp. 6443. Date of Electronic Publication: 2021 Nov 08.
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Typ publikacji:
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Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
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Język:
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English
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Imprint Name(s):
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Original Publication: [London] : Nature Pub. Group
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MeSH Terms:
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Inhibition, Psychological*
Brain/*physiology
Memory/*physiology
Mental Recall/*physiology
Nerve Net/*physiology
Adult ; Brain/physiopathology ; Cues ; Dorsolateral Prefrontal Cortex/physiopathology ; Electroencephalography/methods ; Epilepsy/physiopathology ; Female ; Humans ; Male ; Middle Aged ; Psychomotor Performance/physiology ; Reaction Time/physiology
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References:
-
J Neurosci. 2009 Oct 28;29(43):13613-20. (PMID: 19864573)
Nat Commun. 2019 Apr 3;10(1):1503. (PMID: 30944325)
Trends Neurosci. 2014 Jul;37(7):357-69. (PMID: 24836381)
Sci Rep. 2016 Mar 16;6:23176. (PMID: 26980663)
Cereb Cortex. 2007 Nov;17(11):2507-15. (PMID: 17204822)
Proc Natl Acad Sci U S A. 2018 Jul 31;115(31):E7418-E7427. (PMID: 30006465)
Psychol Rev. 2010 Jan;117(1):197-209. (PMID: 20063968)
Psychol Rev. 1980 Nov;87(6):532-52. (PMID: 7443916)
Neuron. 2016 Jan 20;89(2):384-97. (PMID: 26777277)
Proc Natl Acad Sci U S A. 2017 Jun 27;114(26):6666-6674. (PMID: 28611219)
Cold Spring Harb Perspect Biol. 2012 Jan 01;4(1):a005736. (PMID: 22086977)
Psychol Rev. 1995 Jul;102(3):419-457. (PMID: 7624455)
J Comput Neurosci. 2011 Feb;30(1):45-67. (PMID: 20706781)
Neuroimage. 2012 Feb 15;59(4):3563-70. (PMID: 22155045)
J Neurosci. 2012 Jun 27;32(26):8871-8. (PMID: 22745488)
J Neurosci. 2017 Apr 26;37(17):4472-4480. (PMID: 28336569)
Science. 2013 Nov 1;342(6158):580-4. (PMID: 24179218)
Cereb Cortex. 2020 Jul 30;30(9):4922-4937. (PMID: 32313923)
Biol Psychiatry Cogn Neurosci Neuroimaging. 2018 Apr;3(4):329-336. (PMID: 29628065)
Sci Rep. 2015 Aug 17;5:13021. (PMID: 26278335)
Trends Cogn Sci. 2014 Jun;18(6):279-92. (PMID: 24747000)
Neuron. 2015 Oct 7;88(1):47-63. (PMID: 26447572)
Proc Natl Acad Sci U S A. 2006 Jan 3;103(1):201-6. (PMID: 16371469)
Neuroimage. 2014 Apr 15;90:74-83. (PMID: 24361734)
Trends Cogn Sci. 2014 Jan;18(1):16-25. (PMID: 24268290)
J Neurosci. 2012 Oct 17;32(42):14742-51. (PMID: 23077059)
Phys Rev Lett. 2000 Jul 10;85(2):461-4. (PMID: 10991308)
Trends Cogn Sci. 2006 Feb;10(2):59-63. (PMID: 16406760)
Science. 2007 Jul 13;317(5835):215-9. (PMID: 17626877)
Trends Cogn Sci. 2004 Apr;8(4):170-7. (PMID: 15050513)
Comput Intell Neurosci. 2011;2011:156869. (PMID: 21253357)
Trends Cogn Sci. 2012 Apr;16(4):200-6. (PMID: 22436764)
Neuroimage. 2012 Jul 16;61(4):1402-18. (PMID: 22430496)
Hum Brain Mapp. 2019 Oct 15;40(15):4432-4440. (PMID: 31291043)
Curr Biol. 2015 Jun 15;25(12):1649-53. (PMID: 26028433)
Nat Commun. 2018 Oct 5;9(1):4103. (PMID: 30291240)
Front Syst Neurosci. 2016 Jan 08;9:175. (PMID: 26778976)
Behav Brain Res. 2009 Jun 8;200(1):1-6. (PMID: 19373976)
Hum Brain Mapp. 2017 Mar;38(3):1541-1573. (PMID: 27860095)
Psychol Rev. 2007 Jul;114(3):784-805. (PMID: 17638506)
Proc Natl Acad Sci U S A. 2000 Apr 25;97(9):4649-53. (PMID: 10781070)
Curr Biol. 2015 Mar 2;25(5):635-40. (PMID: 25683804)
Neuropsychologia. 1982;20(3):233-48. (PMID: 7121792)
Neurobiol Learn Mem. 2010 Mar;93(3):352-61. (PMID: 19969099)
Cereb Cortex. 2008 Mar;18(3):670-82. (PMID: 17617657)
Cortex. 2017 Jun;91:67-78. (PMID: 28029355)
Curr Biol. 2020 Jul 6;30(13):2638-2644.e4. (PMID: 32442462)
Front Hum Neurosci. 2010 Nov 04;4:186. (PMID: 21119777)
Front Syst Neurosci. 2013 Dec 27;7:121. (PMID: 24416001)
Nature. 2009 Dec 17;462(7275):915-9. (PMID: 19946267)
Neuron. 2012 Oct 18;76(2):450-60. (PMID: 23083745)
Nat Neurosci. 2009 Mar;12(3):256-8. (PMID: 19219038)
Nature. 2017 Apr 13;544(7649):240-244. (PMID: 28379939)
Cereb Cortex. 2023 Mar 21;33(7):3478-3489. (PMID: 35972419)
Neuroimage. 2017 Sep;158:70-78. (PMID: 28676297)
Brain Res Rev. 2007 Jan;53(1):63-88. (PMID: 16887192)
J Neurosci Methods. 2007 Aug 15;164(1):177-90. (PMID: 17517438)
Cell. 2018 Oct 18;175(3):709-722.e15. (PMID: 30245010)
Proc Natl Acad Sci U S A. 2014 Apr 1;111(13):E1310-9. (PMID: 24639546)
Nat Neurosci. 2008 May;11(5):535-7. (PMID: 18376400)
Cereb Cortex. 2015 Jul;25(7):1938-46. (PMID: 24488943)
J Neurosci. 2011 Apr 6;31(14):5197-204. (PMID: 21471354)
Nat Rev Neurosci. 2003 Aug;4(8):637-48. (PMID: 12894239)
Curr Biol. 2017 Jun 5;27(11):1700-1705.e5. (PMID: 28552361)
Curr Biol. 2018 Sep 24;28(18):3016-3022.e4. (PMID: 30197086)
Nat Commun. 2019 May 21;10(1):2255. (PMID: 31113952)
Physiol Rev. 2011 Oct;91(4):1357-92. (PMID: 22013214)
J Neurosci. 2015 Oct 21;35(42):14341-52. (PMID: 26490871)
Behav Neurosci. 1986 Apr;100(2):147-54. (PMID: 3008780)
J Exp Psychol Gen. 1983 Mar;112(1):58-72. (PMID: 6221062)
Eur J Neurosci. 2005 Dec;22(11):2917-26. (PMID: 16324126)
Nat Rev Neurosci. 2014 Aug;15(8):536-48. (PMID: 24962370)
Neuron. 2015 Jan 21;85(2):390-401. (PMID: 25556836)
eNeuro. 2017 Aug 2;4(4):. (PMID: 28785729)
Nature. 2001 Mar 15;410(6826):366-9. (PMID: 11268212)
Nature. 2009 Jan 15;457(7227):313-7. (PMID: 19005470)
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Grant Information:
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EP-C-15-008 United States EPA EPA
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Entry Date(s):
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Date Created: 20211109 Date Completed: 20211206 Latest Revision: 20240404
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Update Code:
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20240404
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PubMed Central ID:
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PMC8575985
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DOI:
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10.1038/s41467-021-26713-x
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PMID:
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34750407
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Successful forgetting of unwanted memories is crucial for goal-directed behavior and mental wellbeing. While memory retention strengthens memory traces, it is unclear what happens to memory traces of events that are actively forgotten. Using intracranial EEG recordings from lateral temporal cortex, we find that memory traces for actively forgotten information are partially preserved and exhibit unique neural signatures. Memory traces of successfully remembered items show stronger encoding-retrieval similarity in gamma frequency patterns. By contrast, encoding-retrieval similarity of item-specific memory traces of actively forgotten items depend on activity at alpha/beta frequencies commonly associated with functional inhibition. Additional analyses revealed selective modification of item-specific patterns of connectivity and top-down information flow from dorsolateral prefrontal cortex to lateral temporal cortex in memory traces of intentionally forgotten items. These results suggest that intentional forgetting relies more on inhibitory top-down connections than intentional remembering, resulting in inhibitory memory traces with unique neural signatures and representational formats.
(© 2021. The Author(s).)