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Tytuł:
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Lactobacillus plantarum DP189 prevents cognitive dysfunction in D-galactose/AlCl 3 induced mouse model of Alzheimer's disease via modulating gut microbiota and PI3K/Akt/GSK-3β signaling pathway.
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Autorzy:
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Song X; Institute of Agro-food Technology, Jilin Academy of Agricultural Sciences, Changchun, People's Republic of China.; College of Agriculture, Yanbian university, Yanji, People's Republic of China.
Zhao Z; Institute of Agro-food Technology, Jilin Academy of Agricultural Sciences, Changchun, People's Republic of China.
Zhao Y; Institute of Agro-food Technology, Jilin Academy of Agricultural Sciences, Changchun, People's Republic of China.
Wang Z; Department of Nuclear Medicine, General Hospital of Northern Theater Command, Shenyang, People's Republic of China.
Wang C; Institute of Agro-food Technology, Jilin Academy of Agricultural Sciences, Changchun, People's Republic of China.
Yang G; Institute of Agro-food Technology, Jilin Academy of Agricultural Sciences, Changchun, People's Republic of China.
Li S; Institute of Agro-food Technology, Jilin Academy of Agricultural Sciences, Changchun, People's Republic of China.
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Źródło:
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Nutritional neuroscience [Nutr Neurosci] 2022 Dec; Vol. 25 (12), pp. 2588-2600. Date of Electronic Publication: 2021 Nov 10.
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Typ publikacji:
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Journal Article
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Język:
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English
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Imprint Name(s):
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Publication: 2016- : Abingdon : Taylor & Francis
Original Publication: [Amsterdam?] : Harwood Academic Publishers : Overseas Publishers Association [distributor], c1998-
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MeSH Terms:
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Alzheimer Disease*/chemically induced
Alzheimer Disease*/prevention & control
Alzheimer Disease*/drug therapy
Cognitive Dysfunction*/prevention & control
Gastrointestinal Microbiome*
Lactobacillus plantarum*/physiology
Animals ; Mice ; Disease Models, Animal ; Galactose ; Glycogen Synthase Kinase 3 beta/metabolism ; Phosphatidylinositol 3-Kinases/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; Signal Transduction
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Contributed Indexing:
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Keywords: Alzheimer’s disease; GSK-3β; Lactobacillus plantarum; PI3K; cognitive dysfunction; gut microbiota; microbiota-gut-brain axis; probiotics
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Substance Nomenclature:
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X2RN3Q8DNE (Galactose)
EC 2.7.11.1 (Glycogen Synthase Kinase 3 beta)
EC 2.7.1.- (Phosphatidylinositol 3-Kinases)
EC 2.7.11.1 (Proto-Oncogene Proteins c-akt)
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Entry Date(s):
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Date Created: 20211110 Date Completed: 20221109 Latest Revision: 20221109
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Update Code:
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20240105
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DOI:
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10.1080/1028415X.2021.1991556
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PMID:
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34755592
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Probiotic intervention has beneficial effects on host brain function and behavior via regulating microbiota-gut-brain axis; however, the underlying mechanism is not yet understood. Herein, we investigated that the effects of Lactobacillus plantarum DP189 (DP189) administration in preventing cognitive dysfunction and pathology of Alzheimer's disease (AD) in D-galactose (D-gal) and AlCl 3 -induced AD model mice. After L. plantarum DP189 intervention for 10 weeks, we assessed cognitive behavior, neurotransmitter expression, histological changes, microbial communities, and the mechanisms underlying the disease in AD model mice. The results showed that L. plantarum DP189 intervention prevented cognitive dysfunction by behavioral test. Increased levels of serotonin, dopamine, and gamma-aminobutyric acid positively affected the pathological processes by ameliorating neuronal damage, beta-amyloid deposition, and tau pathology. L. plantarum DP189 intervention simultaneously modulated the gut microbial communities to alleviate gut dysbiosis. Moreover, L . plantarum DP189 inhibited tau hyperphosphorylation by regulating the PI3 K/Akt/GSK-3β pathway. These findings indicated that L. plantarum DP189 intervention is a promising therapeutic strategy to prevent the onset and development of AD.
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