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Tytuł pozycji:

Biological evaluation of a novel bilirubin adsorbent and its therapeutic effect on animal models of hyperbilirubinemia.

Tytuł:
Biological evaluation of a novel bilirubin adsorbent and its therapeutic effect on animal models of hyperbilirubinemia.
Autorzy:
Su R; Tianjin City Second People's Hospital, Hepatology Department, Tianjin, China.; Tianjin Institute of Hepatology, Medical Bioengineering Laboratory, Tianjin, China.
Chen G; Tianjin City Second People's Hospital, Hepatology Department, Tianjin, China.
Yan L; Tianjin City Second People's Hospital, Hepatology Department, Tianjin, China.; Tianjin Institute of Hepatology, Medical Bioengineering Laboratory, Tianjin, China.
Liu W; Tianjin City Second People's Hospital, Hepatology Department, Tianjin, China.; Tianjin Institute of Hepatology, Medical Bioengineering Laboratory, Tianjin, China.
Zhao S; Tianjin City Second People's Hospital, Hepatology Department, Tianjin, China.
Dai Q; Tianjin City Second People's Hospital, Hepatology Department, Tianjin, China.; Tianjin Institute of Hepatology, Medical Bioengineering Laboratory, Tianjin, China.
Yuan S; Tianjin First Central Hospital, Animal Laboratory Center, Tianjin, China.
Shen X; Tianjin City Second People's Hospital, Hepatology Department, Tianjin, China.
Yu W; Tianjin City Second People's Hospital, Hepatology Department, Tianjin, China.
Gong X; Tianjin City Second People's Hospital, Hepatology Department, Tianjin, China.
Yu M; Tianjin City Second People's Hospital, Hepatology Department, Tianjin, China.; Tianjin Institute of Hepatology, Medical Bioengineering Laboratory, Tianjin, China.
Źródło:
Journal of biomedical materials research. Part B, Applied biomaterials [J Biomed Mater Res B Appl Biomater] 2022 Apr; Vol. 110 (4), pp. 828-837. Date of Electronic Publication: 2021 Nov 12.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
Język:
English
Imprint Name(s):
Original Publication: Hoboken, NJ : John Wiley & Sons, c2003-
MeSH Terms:
Bilirubin*
Digestive System Diseases*
Adsorption ; Animals ; Humans ; Hyperbilirubinemia/therapy ; Models, Animal
References:
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Contributed Indexing:
Keywords: ERM-0100; adsorption efficiency; bilirubin; biocompatibility; hyperbilirubinemia
Substance Nomenclature:
RFM9X3LJ49 (Bilirubin)
Entry Date(s):
Date Created: 20211112 Date Completed: 20220331 Latest Revision: 20220401
Update Code:
20240104
DOI:
10.1002/jbm.b.34963
PMID:
34767679
Czasopismo naukowe
Hyperbilirubinemia caused severe hepatobiliary diseases with various causes, especially hepatic fibrosis and cirrhosis caused by end-stage hepatitis B and C. Plasma adsorption perfusion (PP) has a tremendous advantage in treating patients with hyperbilirubinemia and liver failure, wherein, a safe and effective adsorbent is the key to filter out bilirubin successfully in PP. In this work, a simple engineering strategy, a new porous polymer adsorption resin ERM-0100 based on the homopolymer predispersion system, is proposed to produce high-performance bilirubin adsorbents. Preliminary experimental results show that ERM-0100 exhibits a large surface area and uniformly porous structure. Experimental results verify that ERM-0100 has high biocompatibility and bilirubin adsorption efficiency (TBIL:35%, direct bilirubin [DBIL]:30%, IBIL:87%) that is significantly higher than most of the reported adsorbents. Animal experiments prove that ERM-0100 has high bilirubin adsorption efficiency and can improve the liver function of animals. The combination of high biocompatibility and high adsorption capacity positions the ERM-0100 as a promising candidate for bilirubin removal.
(© 2021 Wiley Periodicals LLC.)

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